Trained immunity in pregnancy: Impact on maternal-fetal outcomes and mechanistic insights [0.03%]
孕期训练免疫：对母婴结局的影响及机制见解
Sirui Liu,Jia Liang,Dongyong Yang et al.
Sirui Liu et al.
Trained immunity, defined as the epigenetic and metabolic reprogramming of innate immune cells that shapes their subsequent responses, has emerged as a key paradigm in reproductive immunology. In pregnancy, trained immunity can act as a "do...
Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model [0.03%]
在怀孕期间使用二甲双胍治疗或生活方式干预可部分改善母鼠高脂喂养引起的母婴不良影响：小鼠模型研究
Tobias Kretschmer,Eva-Maria Turnwald,Antje Thiele et al.
Tobias Kretschmer et al.
Introduction: Studies showed that metabolic imbalances during pregnancy in obesity impair the maternal-fetal axis, resulting in fetal growth disturbances with higher risk later in life. Since research has linked many of m...
AQP3 in amniotic epithelial cells: A key mediator of cell survival [0.03%]
人胎盘羊膜上皮细胞中AQP3的表达及其与细胞生存的关系
Mauricio Di Paola,Matías N Sierra,Nazarena Fernández et al.
Mauricio Di Paola et al.
Objective: To investigate the regulation and functional role of aquaporin 3 (AQP3) in human amniotic epithelial cells in response to osmotic stress. Metho...
Cardiovascular health in early pregnancy and circulating placental biomarkers [0.03%]
早孕期心血管健康状况与循环胎盘生物标志物之间的关系
Andrea C Kozai,Bethany Barone Gibbs,Samuel Parry et al.
Andrea C Kozai et al.
Background: Maternal cardiovascular and placental health are related to pregnancy outcomes, yet how cardiovascular health (CVH) in early pregnancy affects placentation is not well characterized. Our objective was to estim...
Assessing the transplacental passage and breastmilk levels of broccoli sprout-derived sulforaphane [0.03%]
评估由 Broccoli Sprout 衍生的硫代葡萄糖苷和芥子油甘在母体与胎儿之间的胎盘传递及在乳汁中的水平
Emily F Whalen,Neville J Fields,Kirsten R Palmer et al.
Emily F Whalen et al.
Introduction: Preeclampsia is characterised by hypertension with maternal end-organ dysfunction and/or fetal growth restriction. Sulforaphane, an antioxidant found in broccoli sprouts, has potential as a future therapeuti...
Editorial: SLIMP2024 [0.03%]
编者按：SLIMP2024
Fernanda Giachini,Alexandre Borbely,Alicia E Damiano
Fernanda Giachini
Midpregnancy maternal circulating angiogenic biomarkers: Associations with placental dysfunction-related pregnancy complications and fetal sex [0.03%]
孕期母体循环血管生成生物标志物与胎盘功能障碍相关妊娠并发症及胎儿性别之间的关系
Birgitte Kordt Sundet,Karin C Lødrup Carlsen,Guttorm Haugen et al.
Birgitte Kordt Sundet et al.
Introduction: Placental function differs by fetal sex, and placental dysfunction is associated with adverse pregnancy outcomes. We aimed to investigate the role of midpregnancy maternal circulating placenta-associated ang...
E Pierik,M H de Jong-Schoots,M Bulthuis et al.
E Pierik et al.
Introduction: Preeclampsia complicating pregnancy can be life-threatening for both mother and infant, often resulting in maternal and neonatal morbidity. Previous studies have related changes in specific immune factors to...
SARS-CoV-2 infection disrupts syncytial and endothelial integrity and alters PlGF levels in the placenta [0.03%]
SARS-CoV-2感染会破坏合体和内皮的完整性并改变胎盘中PlGF水平
Brittany R Jones,Guilherme M Nobrega,Deepak Kumar et al.
Brittany R Jones et al.
Introduction: SARS-CoV-2 infection during pregnancy has been associated with an increased risk for several pregnancy-related disorders, particularly preeclampsia (PE). However, there are limited studies determining the im...
Participation of kynurenine pathway metabolites in Trypanosoma cruzi infection of human placenta [0.03%]
人胎盘中犬丝虫感染参与克鲁氏锥虫感染的影响
María José Moreira-Espinoza,Luciana Mezzano,Martin G Theumer et al.
María José Moreira-Espinoza et al.
Introduction: The kynurenine pathway is a major route of tryptophan (Trp) metabolism, an essential amino acid. This pathway, mediated by Indoleamine 2,3-dioxygenase (IDO), contributes to maternal-fetal tolerance by deplet...