Pan-viral metagenomic sequencing demonstrates that cryptic viral infection is rarely observed in villitis of unknown etiology [0.03%]
泛病毒宏基因组测序显示，在病因不明的绒毛羊膜炎中很少观察到隐匿性病毒感染现象
Andrew P Norgan,Qandeel Sadiq,Bohdana Fedyshyn et al.
Andrew P Norgan et al.
Introduction: Aberrant maternal immune responses are implicated in villitis of unknown etiology (VUE), but the underlying cause of this loss of tolerance, including cryptic causative or precipitating infections, has been ...
The downregulation of B2R inhibits spiral artery remodeling by reducing the autophagy of trophoblast cells [0.03%]
B2R下调通过减少滋养细胞自噬抑制螺旋动脉重塑
Weichen Pan,Rongrong Zhu,Xiaoyu Wang et al.
Weichen Pan et al.
Preeclampsia (PE) is a severe pregnancy complication characterized by hypertension and proteinuria after 20 weeks of gestation, posing significant risks to maternal and fetal health. Although its exact etiology remains unclear, inadequate t...
Fetal aorta assessment and cardiovascular biophysical indices in small for gestational age fetuses [0.03%]
小胎龄胎儿主动脉评估及心血管生物物理指标
Simou Maria,Sapantzoglou Ioakeim,Psarris Alexandros et al.
Simou Maria et al.
Background: Cardiovascular disease ranks among the foremost causes of morbidity in adults and recent studies indicate that the process of atheromatosis appears to commence as early as fetal life. This study examined diffe...
Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying vascular dysfunction in preeclampsia [0.03%]
胎盘血管生成调节因子的内皮细胞反应强调了子痫前期血管功能障碍背后的代谢机制
Priscila R Nunes,Ricardo M Bruder,Julyane N S Kaihara et al.
Priscila R Nunes et al.
Introduction: An elevated sFlt-1/PlGF ratio in preeclampsia (PE) directly impairs endothelial cell (EC) metabolism, leading to increased lactate dehydrogenase (LDH) release, lipid peroxidation, and mitochondrial dysfuncti...
Placental slice techniques in physiology, pathophysiology, and toxicology: A systematic review with a focus on precision-cut slices [0.03%]
胎盘切片技术在生理学、病理生理学和毒理学中的应用：以精密切片为重点的系统性综述
H Wang,F A Elzinga,A Nagelkerke et al.
H Wang et al.
Placental precision-cut tissue slices offer an advanced in vitro model that preserves tissue architecture and microenvironment, improving physiological relevance over traditional methods such as animal models and cell lines. This systematic...
Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes [0.03%]
母体肥胖和妊娠糖尿病条件下胎盘线粒体结构动力学及清除障碍的研究
Leena Kadam,Kaylee Chan,Ethan Tawater et al.
Leena Kadam et al.
Introduction: The placenta is exposed to an altered metabolic environment in obesity and gestational diabetes (GDM) leading to disruption in placental function. Mitochondria are critical for energy production and cellular...
Comparative proteomic analysis of placental trophoblasts from normotensive and preeclamptic pregnancies in response to vitamin D [0.03%]
维生素D诱导正常妊娠和子痫前期胎盘滋养细胞蛋白组学比较分析
Jie Xu,Yang Gu,Xinggui Shen et al.
Jie Xu et al.
Background: Vitamin D deficiency/insufficiency is a risk factor for preeclampsia. Vitamin D is known to support placental trophoblast function, yet the cellular and molecular mechanisms underlying trophoblast responses to...
Gestational fine particulate matter exposures and spontaneous preterm birth: Elucidating mechanisms using placental transcriptome and metabolome signatures [0.03%]
孕期细颗粒物暴露与自发性早产：利用胎盘转录组和代谢组标志物阐明机制
Jagadeesh Puvvula,Aimin Chen,Rebecca Simmons et al.
Jagadeesh Puvvula et al.
Background: This study aims to evaluate the mediating role of placental transcriptomic and metabolomic changes in the association between gestational exposure to fine particulate matter and spontaneous preterm birth (sPTB...
NNMT expression in preeclampsia: Analyses on placental tissues and cell lines [0.03%]
溶黄素甲基转移酶在子痫前期中的表达：胎盘组织和细胞系分析
Giovanni Tossetta,Roberto Campagna,Sonia Fantone et al.
Giovanni Tossetta et al.
Objective: Preeclampsia (PE) is a multisystem disorder characterized by new onset hypertension and proteinuria during pregnancy. Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nic...
Characterization of placental pathology in Beckwith-Wiedemann Syndrome due to alterations in the KCNQ1OT1:TSS-DMR region [0.03%]
KCNQ1OT1:TSS-DMR区域改变所致贝克威斯-奥尔波特综合征胎盘病理特征的研究
Sanam L Kavari,Andrew M George,Rebecca L Linn et al.
Sanam L Kavari et al.
Introduction: Beckwith-Wiedemann Syndrome (BWS) is an imprinting disorder characterized by fetal and placental overgrowth. BWS is most often caused by genetic and epigenetic alterations involving the KCNQ1OT1-TSS:DMR (IC2...