Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells [0.03%]
抑制15-前列腺素脱氢酶可减轻乙酰氨基酚致肝损伤：通过抑制肝内皮细胞凋亡实现
Hiroaki Shimada,Akito Yokotobi,Nonoka Yamamoto et al.
Hiroaki Shimada et al.
Hepatic microvascular disruption caused by injury to liver sinusoidal endothelial cells (LSECs) is an aggravating factor for drug-induced liver injury (DILI). It is suggested that prostaglandin E2 (PGE2) may be able to attenuate LSEC injury...
Association of maternal blood and umbilical cord blood plasma fatty acid levels with the body size at birth of Japanese infants [0.03%]
日本母体及脐带血浆中脂肪酸水平与婴儿出生体重身长的关联研究
Azusa Matsumoto,Terue Kawabata,Yasuo Kagawa et al.
Azusa Matsumoto et al.
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), mainly obtained from fish, have been implicated in fetal development. Because few studies have examined maternal and umbilical cord blood fatty acid levels and infant body size in ...
Regular moderate physical activity potentially accelerates and strengthens both the pro-inflammatory and pro-resolving lipid mediator response after acute exercise stress [0.03%]
定期进行中等强度的体育活动可能加速并增强急性运动压力后的促炎症和促解决脂质介质反应
Linda Malan,Lizelle Zandberg,Cindy Pienaar et al.
Linda Malan et al.
The PUFA-derived lipid mediator response shifts from pro-inflammatory to inflammation resolution over time and may be modified by regular moderate exercise. This pre-post-test study aimed to compare the expression of PTGES2 (COX2) and ALOX1...
Resolvin D1 suppresses macrophage senescence and splenic fibrosis in aged mice [0.03%]
_RESOLUTION D1 抑制小鼠衰老过程中的巨噬细胞衰老和脾纤维化
Anouk G Groenen,Masharh Lipscomb,Ramon Bossardi Ramos et al.
Anouk G Groenen et al.
Aging is associated with systemic, non-resolving inflammation and the accumulation of senescent cells. The resolution of inflammation (or inflammation-resolution) is in part mediated by the balance between specialized pro-resolving mediator...
Omega-3 supplementation changes the physical properties of leukocytes but not erythrocytes in healthy individuals: An exploratory trial [0.03%]
欧米茄-3补充剂可改变健康人体白细胞但不能改变红细胞的物理特性：一项探索性试验
Jan Philipp Schuchardt,Martin Kräter,Maximilian Schlögel et al.
Jan Philipp Schuchardt et al.
n3-PUFA impact health in several ways, including cardiovascular protection and anti-inflammatory effects, but the underlying mechanisms are not fully understood. In this exploratory study involving 31 healthy subjects, we aimed to investiga...
The efficacy and acceptability of anti-inflammatory omega-3 polyunsaturated fatty acid supplements in sepsis management: a network meta-analysis of randomized controlled trials [0.03%]
抗炎性Ω-3多不饱和脂肪酸补充剂在治疗脓毒症方面的有效性和可接受度：随机对照试验的网状meta分析
Ping-Tao Tseng,Bing-Yan Zeng,Bing-Syuan Zeng et al.
Ping-Tao Tseng et al.
Sepsis is a critical medical condition associated with high mortality for patients. Current pharmacological strategies for sepsis management or prevention had not achieved satisfactory results. The omega-3 fatty acids, with anti-inflammator...
9-HODE and 9-HOTrE alter mitochondrial metabolism, increase triglycerides, and perturb fatty acid uptake and synthesis associated gene expression in HepG2 cells [0.03%]
9-羟多烯酸和9-羟二十碳四烯酸改变线粒体代谢，增加甘油三酯，并在HepG2细胞中干扰脂肪酸摄取和合成相关基因表达
William A Evans,Jazmine A Eccles-Miller,Eleanor Anderson et al.
William A Evans et al.
Non-Alcoholic Fatty Liver Disease (NAFLD) prevalence is rising and can lead to detrimental health outcomes such as Non-Alcoholic Steatohepatitis (NASH), cirrhosis, and cancer. Recent studies have indicated that Cytochrome P450 2B6 (CYP2B6) ...
Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier [0.03%]
视网膜外屏障的内源性细胞保护机制及其在糖尿病中的作用丧失
Nami Nishikiori,Megumi Watanabe,Tatsuya Sato et al.
Nami Nishikiori et al.
The aim of the present study was to elucidate unknown effects of intraocular fatty acids (ioFAs) including palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidonic acid (C20:4), eicosapentaenoic ac...
12-Hydroxyeicosatetraenoic acid is the only enzymatically produced HETE increased under brain ischemia [0.03%]
脑缺血时十二氢氧二十碳四烯酸是唯一增加的白三烯代谢物
Mikhail Y Golovko,Drew R Seeger,Brennon Schofield et al.
Mikhail Y Golovko et al.
Hydroxyeicosatetraenoic acids (HETE) are dramatically increased under brain ischemia and significantly affect post-ischemic recovery. However, the exact mechanism of HETE increase and their origin under ischemia are poorly understood. HETE ...
Beneficial effects of dietary omega 3 polyunsaturated fatty acids on offspring brain development in gestational diabetes mellitus [0.03%]
妊娠糖尿病患者膳食ω-3多不饱和脂肪酸对子代脑发育的有益作用
Nisha Kemse,Sunaina Chhetri,Sadhana Joshi
Nisha Kemse
Various mechanisms through which maternal diet influences offspring brain development in gestational diabetes mellitus (GDM) remains unclear. We speculate that prenatal omega 3 fatty acids will improve the levels of brain neurotrophins and ...