Fatty acid tissue composition in mice fed diets containing varying levels of Omega-3 fatty acids [0.03%]
不同水平的欧米伽-3不饱和脂肪酸膳食对小鼠组织脂质组成的影响
Nahed Hussein,Irina Dahms,Norman Salem Jr
Nahed Hussein
This study compares varying levels of dietary α-linolenic acid (ALA) as well as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) on the fatty acid composition of multiple tissues. Two-day pregnant, C57Bl6 mice were fed through g...
Linoleic acid promotes mammary tumor growth and metastasis to brain and lung in female Balb/cJ mice [0.03%]
油酸通过促进乳腺肿瘤生长和向肺、脑转移增加雌性Balb/cJ小鼠的死亡风险
Maria Sanchez-Juarez,Monica Vizcarra-Soto,Rocio Castillo-Sanchez et al.
Maria Sanchez-Juarez et al.
Breast cancer is the leading cause of mortality among women worldwide. The largest prevalence of breast cancer is present in high-income nations, but the incidence in low- to middle-income countries has risen in recent years, which is the c...
Early-life feeding of arachidonic acid and docosahexaenoic acid beneficially modulated ileum and splenocyte oxylipins to support oral tolerance development in allergy-prone BALB/c mice [0.03%]
花生四烯酸和二十碳六烯酸的早期喂养有益地调节了过敏易感BALB/c小鼠口服耐受发育中的回肠和脾细胞氧化脂质体
Ren Wang,Dhruvesh Patel,Susan Goruk et al.
Ren Wang et al.
Background: Early-life feeding of arachidonic acid (ARA)+docosahexaenoic acid (DHA) has been shown to promote immune changes associated with oral tolerance (OT). Oxylipins have been demonstrated to be modulated by diet an...
Association of birth outcomes with maternal and infant FADS1 rs174547 genotypes in Japanese participants [0.03%]
日本受试者中多不饱和脂肪酸代谢基因型与母体及新生儿相关出生结果之间的关联性研究
Reiko Nita,Terue Kawabata,Yasuo Kagawa et al.
Reiko Nita et al.
N-3 long-chain polyunsaturated fatty acids (n-3LCPUFAs) are crucial for child growth and development particularly for fetal growth in utero and brain development and function. This study examined the relationship between birth outcomes and ...
Dihomo-gamma-linolenic acid (DGLA) is inversely related to risk for cardiac death and cardiovascular events during 2 years follow-up after admission for an acute coronary syndrome [0.03%]
二十碳二烯酸（DGLA）与急性冠脉综合征患者两年随访期间心脏死亡和心血管事件的风险呈负相关关系
Dennis W T Nilsen,Hildegunn Aarsetoey,Volker Poenitz et al.
Dennis W T Nilsen et al.
Background/aim: Dihomo-gamma-linolenic acid (DGLA) is derived from linoleic acid. Its presence in red blood cell (RBC) membranes is mainly due to metabolism and not diet. RBC DGLA was negatively associated with all-cause ...
Fatty acid metabolism in the placentae of gestational diabetes mellitus [0.03%]
妊娠糖尿病胎盘脂肪酸代谢的影响及机制研究进展
Nikita Joshi,Sadhana Joshi
Nikita Joshi
The prevalence of gestational diabetes mellitus (GDM), a metabolic complication during pregnancy is increasing rapidly. It exerts various short and long term effects on the mother and the child. Nonetheless, the mechanisms underlying the pa...
HYPOTHESIS: Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer's disease in humans [0.03%]
假设：脂质保护性二硫键是ApoE4和人类散发性阿尔茨海默病之间缺失的分子联系
Christopher E Ramsden,Roy G Cutler,Xiufeng Li et al.
Christopher E Ramsden et al.
As the principal lipid transporter in the human brain, apolipoprotein E (ApoE) is tasked with transport and protection of highly vulnerable lipids that are required to support and remodel neuronal membranes, in a process that is dependent o...
LTB4 is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT1 receptor activates the free fatty acid receptor 2 [0.03%]
白三烯B4通过BLT1受体激活自由脂肪酸受体2的机制转化为强的人类中性粒细胞NADPH氧化酶激活剂
Yanling Wu,Claes Dahlgren,Huamei Forsman et al.
Yanling Wu et al.
The endogenous neutrophil chemoattractant leukotriene B4 (LTB4) is a biased signalling agonist that potently increases the intracellular concentration of free calcium ions ([Ca2+]i), but alone is a weak activator of the neutrophil superoxid...
Fatty acid synthase global inducible knockout does not alter brain fatty acid concentrations but attenuates cholesterol synthesis in the adult mouse [0.03%]
脂肪酸合成酶的全球诱导型敲除不会改变成年小鼠大脑中的脂肪酸浓度，但会减弱胆固醇的合成
Drew R Seeger,Peddanna Kotha,Svetlana A Golovko et al.
Drew R Seeger et al.
Fatty acid (FA) de novo synthesis, also called de novo lipogenesis (DNL), has a central role in peripheral energy storage and provides structural components for lipid membranes. However, less is known regarding its contribution to brain FA ...
The single-dose kinetics of [1-14C]-labelled EPA and DHA, administered to male rats as TAG, phosphatidylcholine (PC), and lyso-phosphatidylcholine (LPC), is structurally similar across lipid forms and can be described using the same compartmental models [0.03%]
以TAG、磷脂酰胆碱（PC）和溶血磷脂酰胆碱（ LPC）形式给予[1-14C]标记的EPA和DHA的单剂量动力学在血脂形式之间结构相似，并且可以使用相同的隔室模型来描述
Nils Hoem,Stephen Harris,Grace Scott et al.
Nils Hoem et al.
To investigate the systemic kinetics of EPA and DHA across different lipid classes, male rats were administered [1-14C]-radiolabelled EPA and DHA as triglycerides (TAG), phosphatidylcholine (PC), or lyso-phosphatidylcholine (LPC) by gavage....