Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation [0.03%]
在不同程度的n-3多不饱和脂肪酸剥夺膳食下对大鼠脑中多不饱和脂肪酸代谢的调节研究
Hyung-Wook Kim,Jagadeesh S Rao,Stanley I Rapoport et al.
Hyung-Wook Kim et al.
Knowing threshold changes in brain lipids and lipid enzymes during dietary n-3 polyunsaturated fatty acid deprivation may elucidate dietary regulation of brain lipid metabolism. To determine thresholds, rats were fed for 15 weeks DHA-free d...
Dietary long-chain n-3 PUFA, gut microbiota and fat mass in early postnatal piglet development--exploring a potential interplay [0.03%]
长链n-3多不饱和脂肪酸、肠道菌群与仔猪早期生长发育过程中脂肪质量的相互作用关系研究
A D Andersen,L Mølbak,T Thymann et al.
A D Andersen et al.
Dietary n-3PUFA and gut bacteria, particularly Bacteroidetes, have been suggested to be related to adiposity. We investigated if n-3PUFA affected fat storage and cecal bacteria in piglets. Twenty-four 4-day-old piglets were allocated to for...
α-Linolenate reduces the dietary requirement for linoleate in the growing rat [0.03%]
α-亚麻酸可减少生长 rat对亚油酸的膳食需求
P Guesnet,S-M Lallemand,J-M Alessandri et al.
P Guesnet et al.
Background: We hypothesized that due to the absence of a dietary source of omega-3 fatty acids, the essential fatty acid (EFA) deficiency model leads to an overestimate of linoleic acid (LA) requirements. ...
Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial [0.03%]
中等剂量的回复酯化甘油三酯型但非乙酯型的二十碳五烯酸和二十二碳六烯酸可降低他汀治疗患者的空腹血甘油三酯水平：一项为期六个月的随机对照研究的结果
J P Schuchardt,J Neubronner,G Kressel et al.
J P Schuchardt et al.
Recently, in a supplementation study over six months, it has been demonstrated that re-esterified omega-3 fatty acid triacylglycerols (n3-FA-rTAGs) led to a higher increase in omega-3-index compared to identical doses of n3-FA ethyl-esters ...
Randomized Controlled Trial
Prostaglandins, leukotrienes, and essential fatty acids. 2011 Dec;85(6):381-6. DOI:10.1016/j.plefa.2011.07.006 2011
Kathy Musa-Veloso,Theresa H Poon
Kathy Musa-Veloso
Pro- and anti-oxidant effects of polyunsaturated fatty acid supplementation in HepG2 cells [0.03%]
多不饱和脂肪酸补充对HepG2细胞抗氧化及促氧化作用的影响
Mattia Di Nunzio,Veronica Valli,Alessandra Bordoni
Mattia Di Nunzio
PUFA are bioactive nutrients thought to be effective in the prevention of many chronic diseases. PUFA susceptibility to free radical oxidation represents the other side of the coin, and the role of PUFA as pro- or anti-oxidants is still an ...
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population [0.03%]
ALOX5AP基因-1316T/G多态性与韩国人群自发性脑出血的关系研究
Dong Hwan Kim,Woo Yong Ahn,Dong Kwan Kim et al.
Dong Hwan Kim et al.
To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (...
Fatty acid transport into the brain: of fatty acid fables and lipid tails [0.03%]
脑内脂肪酸输送：脂肪酸故事与脂质尾巴
Ryan W Mitchell,Grant M Hatch
Ryan W Mitchell
The blood-brain barrier formed by the brain capillary endothelial cells provides a protective barrier between the systemic blood and the extracellular environment of the central nervous system. Brain capillaries are a continuous layer of en...
Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries [0.03%]
早产儿胎盘长链多不饱和脂肪酸水平降低
Madhavi V Dhobale,Nisha Wadhwani,Savita S Mehendale et al.
Madhavi V Dhobale et al.
Reports suggest that the placenta in preterm birth may provide clues to predicting the risk of individuals developing chronic diseases in later life. Placental delivery of long chain polyunsaturated fatty acids (LCPUFA) (constituents of the...
Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells [0.03%]
二十碳五烯酸通过下调肝细胞中参与脂肪合成基因的表达而降低肝脏脂肪含量
Gunveen Kaur,Andrew J Sinclair,David Cameron-Smith et al.
Gunveen Kaur et al.
Previous studies have shown that Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) exhibit triacylglycerol (TAG) lowering effect in vitro and in vivo by down-regulating the Sterol Regulating Element Binding Protein (SREBP-1c) and r...