Photobleaching alters the morphometric analysis of fluorescently labeled neurons and microglial cells [0.03%]
光漂白改变了荧光标记的神经元和小胶质细胞的形态计量分析
Tamás F Polgár,Krisztina Spisák,Zalán Kádár et al.
Tamás F Polgár et al.
Photobleaching of immunofluorescence signal is a well-known phenomenon, however, its impact on derived parameters characterizing number and shape of different cell types in tissue sections is less understood. Our aim was to determine whethe...
Real-world experience with pazopanib in locally advanced and metastatic soft tissue sarcomas: a Hungarian retrospective single-center study [0.03%]
帕唑帕尼治疗局部晚期和转移性软组织肉瘤的真实世界经验：一项匈牙利单中心回顾性研究
Nóra Ecker,Marietta Aranyi,Edina Kiss et al.
Nóra Ecker et al.
Pazopanib is a tyrosine-kinase inhibitor also used for the treatment of advanced soft tissue sarcomas. Our retrospective study analyzed real-world data of stage 4 sarcoma patients treated with pazopanib in our department in the past 10 year...
Neoadjuvant leukocyte interleukin injection immunotherapy improves overall survival in low-risk locally advanced head and neck squamous cell carcinoma -the IT-MATTERS study [0.03%]
新辅助粒细胞白细胞介素注射免疫治疗可改善低危局部晚期头颈部鳞癌患者的总生存期：MATTERS研究
Eyal Talor,József Tímár,Philip Lavin et al.
Eyal Talor et al.
The randomized controlled pivotal phase 3 study evaluated efficacy and safety of neoadjuvant complex biologic, Leukocyte Interleukin Injection (LI), administered for 3 consecutive weeks pre-surgery, in treatment naïve resectable locally ad...
Are patients with chronic obstructive pulmonary disease at a greater risk for the development of autoimmune thyroiditis as an adverse event of immunotherapy in non-small cell lung cancer treatment? [0.03%]
慢性阻塞性肺疾病患者在非小细胞肺癌治疗中是否因免疫疗法更易诱发自身免疫性甲状腺炎？
Andrej Zecevic,Ana Blanka-Protic,Aleksandar Jandric et al.
Andrej Zecevic et al.
Introduction: Immunotherapy has made a significant improvement in the treatment of patients with non-small cell lung cancer (NSCLC). It has a role in boosting the immune system, so it can fight cancer cells. Sometimes, th...
Observational Study
Pathology oncology research : POR. 2025 Mar 14:31:1612022. DOI:10.3389/pore.2025.1612022 2025
Impact of comprehensive genomic profiling on the diagnosis and clinical management of malignant mesenchymal tumours [0.03%]
全面基因组分析对恶性间叶肿瘤诊断和临床管理的影响
Anna Beáta Csepregi,Eszter Papp,Imola Adamik et al.
Anna Beáta Csepregi et al.
Comprehensive genomic profiling (CGP) is becoming an increasingly important tool in the clinical management of different tumours, but there is still very limited data available on its usefulness from a therapeutic point of view in mesenchym...
Characterization of a novel sarcoma cell line with an EWSR1::POU2AF3 fusion [0.03%]
具有EWSR1::POU2AF3融合特征的新型肉瘤细胞系表征研究
Hannah Schwab,Maximilian Kerkhoff,Pauline Plaumann et al.
Hannah Schwab et al.
Sarcomas with an EWSR1::POU2AF3(COLCA2) fusion are a very recently described entity of preferentially sinonasal origin and with undifferentiated round/spindle cell morphology. We established a novel cell line (PF1095) carrying a EWSR1::POU2...
Case Report: Importance of high-throughput genetic investigations in the differential diagnosis of unexplained erythrocytosis [0.03%]
病例报告：高通量遗传调查在不明原因的红细胞增多症鉴别诊断中的重要性
Zsófia Flóra Nagy,György Pfliegler,János Kósa et al.
Zsófia Flóra Nagy et al.
Introduction: Polycythemia indicates the pathological increase in the number of red blood cells and the rise of hematocrit values. Polyglobulia can be of primary or secondary origin, with the most common primary polycythe...
Case report: Alectinib-associated intestinal ulceration and colitis in a patient with non-small cell lung cancer and effective treatment with Mesalazine [0.03%]
病例报告：非小细胞肺癌患者使用Alectinib引起肠道溃疡和结肠炎，美沙拉嗪治疗有效
Zijian Qiu,Fei Ke,Xiaoping Zhu
Zijian Qiu
Background: Alectinib is effective in extending the survival of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) and generally has manageable side effects. However, intestinal ulc...
Survival trends of gastrointestinal stromal tumor in real-world settings: a population-based retrospective study [0.03%]
胃肠间质瘤在现实世界的生存趋势：基于人口的回顾性研究
Guohua Jia,Xiangpan Li
Guohua Jia
Purpose: This study aims to evaluate whether survival outcomes for GIST patients have improved over the past decades and to identify the specific patient subgroups that have benefited from advances in treatment. ...
David Fellows,Julia Kotowska,Thomas Stevenson et al.
David Fellows et al.
Giant cell tumour of bone (GCTB) is viewed as a benign, locally aggressive primary bone tumour with metastatic potential. Current management is surgery with bone curettage or resection and systemic therapy with denosumab. Diagnosis is confi...