Comprehensive genomic profiling for homologous recombination deficiency guides PARP inhibitor therapy recommendations in ovarian cancer [0.03%]
全面的基因组分析指导卵巢癌同源重组缺陷导向的PARP抑制剂治疗建议
Alp Inci,Isabell Witzel,Holger Moch et al.
Alp Inci et al.
Objective: To evaluate the technical performance and clinical integration of FoundationOne®CDx (F1CDx) for high-grade serous ovarian cancer (HGSOC), focusing on its role in guiding PARP inhibitor (PARPi) therapy recommen...
Trop2 expression, p16 expression status, and histologic subtype in carcinoma of the uterine cervix [0.03%]
子宫颈癌中Trop2表达、p16状态及组织学类型的研究
Grit Gesine Ruth Hiller,Benjamin Wolf,Mirjam Forberger et al.
Grit Gesine Ruth Hiller et al.
Introduction: The antibody-drug conjugate (ADC) Sacituzumab-Govitecan (SG), a humanized anti-Trop2 monoclonal antibody linked to the cytotoxic topoisomerase I inhibitor SN38, achieved promising results in the treatment of...
Examination of histopathological growth patterns of liver metastases in a retrospective, consecutive, single-center, cohort study [0.03%]
一项回顾性、连续的单中心队列研究中肝转移瘤生长模式的病理组织学分析
Anita Sejben,Parsa Abbasi,Boglárka Pósfai et al.
Anita Sejben et al.
Objective: Histopathological growth patterns (HGPs) were identified as prognostic factors for colorectal adenocarcinomas; however, they have been examined in a consecutive setting with controversial results. Our study aim...
Synergistic changes in bystander CD8 and conventional CD4 T cells during neoadjuvant chemoimmunotherapy for non-small cell lung cancer reveal treatment response [0.03%]
新辅助化疗免疫治疗期间旁观者CD8和传统CD4T细胞的协同变化揭示了治疗反应
Li Wu,Liying Yang,Jian Sun et al.
Li Wu et al.
Objective: We analyzed changes in intratumoral CD8+ and CD4+ T-cell subpopulations following neoadjuvant chemoimmunotherapy in non-small cell lung cancer. We then assessed whether these alterations favored better outcomes...
Case Report: From teratoma to adenocarcinoma: molecular insights into somatic-type malignancy in testicular germ cell tumors - two case reports and review of the literature [0.03%]
病例报告：从畸胎瘤到腺癌：对睾丸生殖细胞肿瘤中体细胞类型恶性肿瘤的分子见解-两例报道及文献综述
Tímea Rozsvai,Boglárka Pósfai,László Torday et al.
Tímea Rozsvai et al.
Testicular germ cell tumors (TGCTs), though typically responsive to therapy, may rarely develop somatic-type malignancy (STM), a transformation associated with poor prognosis and chemoresistance. This study presents two cases of postpuberta...
Circulating tumor cells: indicators of cancer progression, plasticity and utility for therapies [0.03%]
循环肿瘤细胞：提示癌症进展、可塑性和治疗用途的指标
Tamás Richárd Linkner,Zsófia Brigitta Nagy,Alexandra Kalmár et al.
Tamás Richárd Linkner et al.
Cancer is a deadly disease affecting millions of people worldwide. Circulating tumor cells (CTCs) represent a critical link between primary malignancies and metastasis, acting as key players in cancer dissemination, progression, and recurre...
Two B or not two B; the question of bendamustine dosing in low grade lymphoma [0.03%]
来那度胺与利妥昔单抗联合治疗复发/难治滤泡性淋巴瘤患者：II 期研究结果
Eszter Földi,Ádám Wiedemann,Szabolcs Svorenj et al.
Eszter Földi et al.
Background: Follicular lymphoma (FL) is an indolent yet incurable B-cell lymphoma subtype commonly treated with a combination of bendamustine and anti-CD20 antibodies such as rituximab. While the standard administration i...
Modelling metastasis in a dish: in vitro approaches for studying breast cancer progression [0.03%]
体外模型在乳腺癌转移中的应用及进展研究
Irem Duman,Verena Pichler
Irem Duman
Cancer metastasis, driven by cell migration, remains the leading cause of cancer-related deaths. In breast cancer, its high metastatic potential underscores the need for better preclinical models to bridge the gap between laboratory finding...
The prognostic potential of circulating biomarkers for sarcoma patients with pleural dissemination [0.03%]
循环生物标志物对肉瘤患者胸膜转移的预后价值
Hannah Schwab,Stéphane Collaud,Sebastian Bauer et al.
Hannah Schwab et al.
Sarcomas are a heterogeneous group of rare and aggressive malignancies and have a propensity to metastasize to the thoracic cavity. While sarcoma lung metastasectomy is an established modality, only scarce information is available about pot...
Ali Al Khader,Christian Seghetti,Fatine Oumlil et al.
Ali Al Khader et al.
Recognition of unusual histological features can augment and hasten a diagnosis but also stimulate ideas about physiological and pathological cellular interactions. Osteoclasts resorb mineralised tissue and therefore can be found at sites o...