Günther Sperk
Günther Sperk
Neuropeptides commonly function as co-transmitters alongside classical neurotransmitters within the same neuron. In temporal lobe epilepsy (TLE), the expression of numerous neuropeptides in the brain is profoundly altered. These changes may...
Somatostatin neurons of the bed nucleus of the stria terminalis drive aversive behaviors in mice [0.03%]
小鼠终纹床核的生长抑素神经元能驱动厌恶行为
Quentin Denis,Konstanze Krimbacher,Harish Iyer et al.
Quentin Denis et al.
Appropriate valence processing, a mechanism believed to assign emotional value to salient stimuli, is a pivotal element of responsive behavior. Malfunctioning of valence processing may compromise behavioral adaptation and facilitate the for...
Revisited case for intranasal neuropeptide Y based therapeutics: From preclinical to clinical [0.03%]
鼻内神经肽Y类药物疗法的再探讨：从临床前研究到临床应用
Esther Louise Sabban,Arax Tanelian
Esther Louise Sabban
Compelling evidence from a variety of approaches attributes manifold benefits to NPY in the brain. NPY can reduce stress, depressive symptoms, pain, neuroinflammation, seizures, and is implicated in attenuating alcohol use disorder and neur...
Netrin-3 rectifies diabetes-induced cognitive impairment by counteracting hippocampal oxidative stress and NLRP3 inflammasome activation [0.03%]
神经素-3通过对抗海马氧化应激和NLRP3炎症小体激活来修正糖尿病引起的认知障碍
Yanhong Wang,Mengmeng Pu,Xuexue Wang
Yanhong Wang
Diabetes frequently causes substantial cognitive decline, yet available treatments offer minimal benefit. Netrin-3, a laminin-like protein, regulates nervous system development and inflammatory responses. However, its involvement in diabete...
The phoenixin-14/GPR173 Axis enhances post-stroke angiogenesis through ETS1-mediated VEGF signaling [0.03%]
凤凰涅槃基因在中风后血管生成中的作用机制研究
Fangjie Luo,Xiaoyun Li,Guodao Wen et al.
Fangjie Luo et al.
Intracerebral hemorrhage (ICH) contributes to poor neurological outcomes by interfering with angiogenesis and disrupting important signaling pathways. Through ETS1-mediated vascular endothelial growth factor (VEGF) signaling, this work exam...
Oxytocin beyond social bonding: Advancing neuromodulation, synaptic plasticity, and epigenetic precision in CNS disorders [0.03%]
缩宫素与社交纽带：推进中枢神经系统疾病的神经调节、突触可塑性和表观遗传精確性
Supratim Paul,Janvi Verma,Sidharth Mehan
Supratim Paul
Oxytocin, a neuropeptide predominantly produced in the hypothalamus, has garnered significant attention for its multifaceted roles extending beyond social bonding and reproduction to therapeutic applications in neurodegenerative and neurops...
Oxytocin as a neurotherapeutic target for nicotine withdrawal and craving modulation [0.03%]
催产素作为尼古丁戒断和渴求的神经治疗靶点
Rushikesh Thanekar,Brijesh Taksande,Milind Umekar et al.
Rushikesh Thanekar et al.
Nicotine addiction is a chronic relapsing disorder driven by neuroadaptive changes in reward, stress, and emotional regulation systems. Withdrawal symptoms, including anxiety, irritability, cravings, and anhedonia, significantly hinder smok...
Differential effects of orexin system activation on dizocilpine-induced schizophrenia-like behaviors in mice [0.03%]
选择性激活 orexin 系统对氯氮平诱导的小鼠类精神分裂症样行为的疗效及机制研究
Anna Burckhardt,Anne Rakowsky,Evelyn Kahl et al.
Anna Burckhardt et al.
Schizophrenia encompasses positive, negative, and cognitive symptoms, and accumulating evidence suggests that the orexin system may modulate circuits relevant to these domains. Here, we investigated whether orexin-related interventions infl...
The role of galanin/GALR2 signaling in the link between type 2 diabetes and Alzheimer's disease [0.03%]
галанин/ГАЛР2信号在2型糖尿病和阿尔茨海默病关联中的作用
Mengfan Xu,Jia Wang,Yuqing She et al.
Mengfan Xu et al.
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are two major healthcare problems among the elderly worldwide. Several epidemiological studies suggest that T2DM is associated with an increased risk of developing AD, leading to ...
Targeting the brain through the nose: Advances in polymeric nanoparticle delivery for schizophrenia [0.03%]
通过鼻腔递送聚合物纳米颗粒靶向大脑用于治疗精神分裂症的进展
Teja Kumar Ponduri,G S N Koteswara Rao
Teja Kumar Ponduri
Intranasal delivery of polymeric nanoparticles (PNPs) offers a promising approach for improving drug delivery to the central nervous system (CNS), particularly for treating schizophrenia. This delivery method enables direct nose-to-brain tr...