Isolation and functional characterization of novel neuropeptides regulating hippocampal neurogenesis [0.03%]
新型神经肽的分离及其对海马神经发生调节的功能表征
Arezu Marefat,Leila Sadeghi,Gholamreza Dehghan
Arezu Marefat
Neuropeptides (NPs) are small peptides, produced and secreted by neurons, serving as neuromodulators and chemical messengers that influence neuronal growth, proliferation, and differentiation. Despite their diverse and important roles, the ...
Stress and the activation of periventricular substance P receptors differently regulate the serotonergic system in the brain and ACTH release in male rats [0.03%]
压力通过活化室周脑啡肽能神经元调节雄性大鼠脑内五羟色胺系统的不同机制及其对促肾上腺皮质激素释放的影响
Heidi Spitznagel,Yi Zhao,Jürgen Hedderich et al.
Heidi Spitznagel et al.
Activation of periventricular and hypothalamic substance P (SP) (NK1) receptors triggers the classical defence (stress) reaction but inhibits the hypothalamic-pituitary-adrenal (HPA) axis. The mechanisms of the HPA axis inhibition by SP are...
Bromelain administration improves learning and memory, reduces astrogliosis, and increases BDNF expression in rats with thioacetamide-induced hepatic encephalopathy model [0.03%]
木瓜蛋白酶给药改善肝性脑病大鼠学习和记忆，减少星形胶质细胞增生并增加BDNF表达
Maral Hasanzadeh,Amirreza Beirami,Armin Alinezhad et al.
Maral Hasanzadeh et al.
Hepatic encephalopathy refers to the group of neuropsychiatric disorders occurring in individuals having liver dysfunction as well as portosystemic shunting. Bromelain is defined as antioxidant extracted from pineapple stems. In this resear...
Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome [0.03%]
亲吻肽-54通过AMPK介导的NLRP3炎性小体抑制作用缓解败血症小鼠急性肺损伤
Xian Wang,Zhihong Zou,Hui Huang
Xian Wang
Sepsis-induced acute lung injury (ALI) remains a leading cause of death in intensive care, yet targeted therapies are lacking. Kisspeptin-54 is a neuropeptide primarily known for reproductive regulation, though its role in sepsis is unexplo...
The hemoglobin-derived peptide LVV-H7 attenuates select behavioral alterations in male spontaneously hypertensive rats [0.03%]
血红蛋白衍生肽LVV-H7可改善男性的自发性高血压大鼠部分行为异常症状
Hanniely Thais Menezes Santos,Stefanne Madalena Marques,André Luís Elias Moreira et al.
Hanniely Thais Menezes Santos et al.
LVV-H7 is a decapeptide derived from the β-hemoglobin chain, with its mRNA expressed in multiple brain regions implicated in the regulation of endocrine functions and behavior. LVV-H7 inhibits the insulin-regulated aminopeptidase (IRAP) ca...
Ewa Krawczyk,Joanna Kitlinska
Ewa Krawczyk
Neuropeptide Y (NPY) is a sympathetic neurotransmitter, abundant in the central and peripheral nervous systems. Acting via its G protein-coupled receptors, Y1R, Y2R and Y5R, NPY regulates many physiological processes, such as stress respons...
Expression of the Galanin system in the human pancreas, pancreatitis, and pancreatic cancer: Association with nodal involvement and perineural invasion [0.03%]
人胰腺、急性胰腺炎和胰腺癌中的加兰霖系统的表达与淋巴结受累及神经周围侵犯的关系
Sara Huber,Julia Gering,Stefanie Gaisbauer et al.
Sara Huber et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a five-year survival rate of 6%, yet the underlying causes remain poorly understood. The neuropeptide galanin (GAL) and its three receptors (GAL1-3-R) a...
PACAP promotes mitochondrial biogenesis in rat primary chondrocytes via the SIRT1/PGC-1α pathway [0.03%]
胰高血糖素样肽通过SIRT1/PGC-1α通路促进大鼠原代软骨细胞线粒体生物合成
Liwei Xiong
Liwei Xiong
Mitochondrial biogenesis is essential for maintaining energy homeostasis and chondrocyte function in articular cartilage, and its impairment contributes to cartilage degeneration and osteoarthritis pathogenesis. PACAP (pituitary adenylate c...
Galanin receptor 2: A multifunctional modulator in neurological diseases - Structure, mechanisms, and therapeutic prospects [0.03%]
神經肽Y受體2：神經系統疾病多功能調節因子-結構、機制及治療前景
Yuxin Dai,Zitong Zhao,Yuting Song et al.
Yuxin Dai et al.
Galanin receptor 2 (GALR2), as a subtype of neuropeptide galanin receptor, is predominantly expressed in the central and peripheral nervous systems. Accumulating evidence suggests that GALR2 is involved in the pathogenesis of depression, Al...
Re-thinking neuropeptide therapeutics: What Neuropeptide Y and Galanin teach us about stress, resilience, and drug design [0.03%]
从神经肽Y和加压素重新思考神经肽治疗：压力，适应性和药物设计的启示
Grinal Corriea,Etienne Sibille
Grinal Corriea
Neuropeptide Y (NPY) and galanin (GAL), two of the most abundant neuropeptides in the mammalian nervous system, are consistently associated with brain disorders, yet their therapeutic potential remains unrealized. Both are state-dependent m...