The role of galanin/GALR2 signaling in the link between type 2 diabetes and Alzheimer's disease [0.03%]
галанин/ГАЛР2信号在2型糖尿病和阿尔茨海默病关联中的作用
Mengfan Xu,Jia Wang,Yuqing She et al.
Mengfan Xu et al.
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are two major healthcare problems among the elderly worldwide. Several epidemiological studies suggest that T2DM is associated with an increased risk of developing AD, leading to ...
Targeting the brain through the nose: Advances in polymeric nanoparticle delivery for schizophrenia [0.03%]
通过鼻腔递送聚合物纳米颗粒靶向大脑用于治疗精神分裂症的进展
Teja Kumar Ponduri,G S N Koteswara Rao
Teja Kumar Ponduri
Intranasal delivery of polymeric nanoparticles (PNPs) offers a promising approach for improving drug delivery to the central nervous system (CNS), particularly for treating schizophrenia. This delivery method enables direct nose-to-brain tr...
Modulating neuropeptide Y pathways to combat nicotine addiction through emerging evidence and future directions [0.03%]
通过新证据和未来方向调节神经肽Y通路以对抗尼古丁成瘾
Sameer Khidkikar,Divya Malode,Brijesh Taksande et al.
Sameer Khidkikar et al.
Nicotine addiction constitutes a significant global health burden, primarily driven by the substance's capacity to dysregulate the brain's reward and stress systems. This chronic relapsing disorder is characterized by robust dependence and ...
Neuropeptide Y at the crossroads of neurodegeneration: Mechanistic insights and emerging therapeutic strategies [0.03%]
神经肽Y在神经退行性病变的交叉路口：机制见解和新兴治疗策略
Viswanthram Palanivel,Akanksha Salkar,Avinash Shenoy et al.
Viswanthram Palanivel et al.
Neuropeptide Y (NPY), a widely distributed and highly conserved neuropeptide, plays a central role in the regulation of diverse physiological processes, including stress responses, energy homeostasis, vascular tone, and immune modulation, v...
ATP drives the leptin inhibition of voltage-gated calcium channels via AMPK in isolated neurons of arcuate nucleus in male rats [0.03%]
在雄性大鼠下丘脑弓状核分离的神经元中，ATP通过AMPK介导瘦素对电压门控钙通道的抑制作用
Karina Bermeo,Margarita Jacaranda Rosendo-Pineda,Tamara Arenas et al.
Karina Bermeo et al.
Energy balance is controlled by multiple structures in the central nervous system. Hypothalamus, particularly arcuate nucleus, is a key region in the neuronal control of energy homeostasis. Leptin, an anorexigenic hormone, inhibits voltage-...
Evaluating the efficacy of neurotensin receptor-1 antagonist SR48692 in high-fat diet-induced neurotoxicity in mice: An in vivo study [0.03%]
SR48692对神经紧张素受体-1的拮抗作用在高脂饮食诱导的小鼠神经毒性中的有效性评价：一项体内研究
Pradeep Verma,Himanshu Pal,Banalata Mohanty
Pradeep Verma
Overconsumption of high-calorie foods has been linked with enhanced peripheral Neurotensin (NT) secretion. The elevated endogenous NT participates in lipid absorption in the gastrointestinal tract. An impaired neurotensinergic system leads ...
Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells [0.03%]
亲吻肽-10在调节神经炎症中的双重作用：下调微胶质细胞中NLRP3炎性小体激活和Caspase-1介导的焦亡，以及激活BAG3依赖性的聚集体自噬
Ömer Faruk Kalkan,Şeniz Erdem,Mehmet Erdem et al.
Ömer Faruk Kalkan et al.
Background: Microglial NLRP3 inflammasome activation plays a central role in the neuroinflammatory cascade that contributes to the pathogenesis of various neurodegenerative diseases. Activation of the canonical inflammaso...
Nociceptin-mediated SIRT6 downregulation drives cellular senescence in glioblastoma [0.03%]
nociceptin介导的SIRT6下调驱动胶质母细胞瘤细胞衰老
Yankai Xu,Jiesi Zhou,Xiaobin Zhou et al.
Yankai Xu et al.
Cellular senescence plays a crucial role in glioblastoma (GBM), influencing tumor progression and therapeutic resistance. Nociceptin (N/OFQ), an endogenous neuropeptide, and its receptor NOPr are implicated in various pathological processes...
Effects of vasoactive intestinal peptide on neuroexcitability of female-specific subpopulation of myelinated Ah-type neurons isolated from trigeminal ganglia of adult female rats [0.03%]
血管活性肠肽对成年雌性大鼠三叉神经节中特异性亚群Ah型有髓神经元的神经兴奋性的影响
Feng Yan,Pan Zhong-Xuan,Tan Li-Li et al.
Feng Yan et al.
Migraine headache remains a health issue more commonly seen in women with a complicated pathophysiology and is under debate. Vasoactive intestinal peptide (VIP) is a potential factor associated with trigeminovascular system. Here, trigemina...
Pituitary adenylate cyclase-activating polypeptide (PACAP) attenuates diabetic cardiomyopathy via Nrf2/HO-1 antioxidant signaling and NF-κB-mediated inflammation suppression in streptozotocin-treated mice [0.03%]
加压素通过Nrf2/HO-1抗氧化信号和NF-κB介导的抗炎反应减轻链脲佐菌素致小鼠糖尿病心肌病的研究
Dong Yang,Huozhao Ruan,Liancai Chen et al.
Dong Yang et al.
Diabetic cardiomyopathy (DCM), characterized by oxidative stress, inflammation, and pathological remodeling, is still a primary cause of death in diabetes. This study examines how pituitary adenylate cyclase-activating polypeptide (PACAP) m...