Repurposing pentosan polysulfate sodium as hyaluronic acid linked polyion complex nanoparticles for the management of osteoarthritis: A potential approach [0.03%]
硫酸戊聚糖钠作为透明质酸连接的聚离子复合纳米颗粒用于骨关节炎管理的潜在方法再利用研究
Pavitra Solanki,Mohd Danish Ansari,Anjali et al.
Pavitra Solanki et al.
Osteoarthritis is still a disease burden for pharmaceutical scientists and strategy makers. It is associated with the chronic inflammation of joints especially weight-bearing joints like knee, hip, backbone, and phalanges. NSAIDs that are u...
The cell of cancer origin provides the most reliable roadmap to its diagnosis, prognosis (biology) and therapy [0.03%]
癌症起源的细胞为其诊断、预后（生物学）和治疗提供了最可靠的路线图
Rachita Pandya,Kaitlyn Grace San Diego,Talha Shabbir et al.
Rachita Pandya et al.
Cancers arise from single transformed cells from virtually every organ of the body, divide in a relatively uncontrolled manner, and metastasize widely. A search for a "magic bullet" to precisely diagnose, characterize, and ultimately treat ...
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteins [0.03%]
SARS-COV-2 Spike表位序列的分子对接确定了与人类Zo-1，TLR8和大脑特异性胶质蛋白形成异二聚体肽-蛋白质复合物
Subhajit Dasgupta,Mausumi Bandyopadhyay
Subhajit Dasgupta
SARS-COV-2 infection causes severe respiratory tract illness leading to asphyxia and death. The onset of infection is associated with loss of smell, blurred vision, headache with bronchopulmonary symptoms. The clinical observations of neuro...
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes [0.03%]
SARS-CoV-2相关血小板减少症和噬血组织细胞的模型研究
Darrell O Ricke
Darrell O Ricke
A subset of COVID-19 patients is experiencing secondary immune thrombocytopenia, also called immune thrombocytopenic purpura (ITP) or secondary hemophagocytic lymphohistiocytosis (HLH). The pathogenesis of SARS-CoV-2 associated thrombocytop...
Moderate exercise may prevent the development of severe forms of COVID-19, whereas high-intensity exercise may result in the opposite [0.03%]
适度运动或可预防重度新冠肺炎的发展，而高强度运动则可能产生相反效果
B A Hagiu
B A Hagiu
Sedentary lifestyle increases the risk of hospitalization for COVID-19 independently of other factors. There is enough statistics to show that exercise prevents severe forms of COVID-19, but current recommendations do not set an upper limit...
Advanced glycation end-products as potential triggering factors of self-reactivity against myelin antigens in Multiple Sclerosis [0.03%]
高级糖基化终末产物作为可能触发多发性硬化中针对髓鞘抗原的自身免疫反应的因素
Panagis Polykretis
Panagis Polykretis
Multiple Sclerosis (MS) is a demyelinating autoimmune disease in which autoreactive T lymphocytes infiltrate the central nervous system (CNS) and react against antigens derived from proteins of the myelin sheath. The reason why T lymphocyte...
Is there a genetic link between Keratoconus and Fuch's endothelial corneal dystrophy? [0.03%]
圆锥角膜和Fuchs内皮性营养不良之间是否存在遗传联系？
Bharat Gurnani,Kirandeep Kaur,Koushik Tripathy
Bharat Gurnani
Keratoconus (KC) is a noninflammatory, bilateral, progressive corneal stromal thinning disorder that leads to corneal ectasia, central anterior corneal stromal scarring, irregular myopic astigmatism, and reduced visual acuity. Fuchs endothe...
Electrokinesis hypothesis of neuron selection for synapse formation and pruning [0.03%]
神经元选择突触形成和修剪的电动力学假说
Ersin Esen
Ersin Esen
What neurons are connected and what neurons are disconnected? These are crucial questions since they determine the structural connectivity of the brain. We address this matter in question and propose a speculative hypothesis. We claim that ...
Negin Badihian
Negin Badihian
Depression is the second leading cause of disability in the world. Despite developing some efficacious treatments, many patients do not respond to the treatment well due to the complexity of depression and unknown mechanisms involved in its...