PIGA variants are associated with focal epilepsy with favorable outcome and the sub-molecular effect [0.03%]
PIGA变异与局灶性癫痫预后良好的亚分子效应相关
Meizhuang Zhou,Yu Luo,Ruihan Yang et al.
Meizhuang Zhou et al.
Background: The PIGA gene plays a critical role in glycosylphosphatidylinositol (GPI) biosynthesis. PIGA variants have been linked to multiple congenital anomalies-hypotonia-seizures syndrome 2. While epilepsy is a common...
Educational attainment of children with self-limited epilepsy with CentroTemporal spikes (SELECTS), other epilepsies, and without epilepsy: A retrospective cohort study [0.03%]
自身限制性中央颞区棘波癫痫儿童的教育成就：一项回顾队列研究
Arron S Lacey,Carys B Jones,Christopher J Weir et al.
Arron S Lacey et al.
Background: Children with epilepsy may have poorer educational outcomes-this may not be true for all epilepsy syndromes. We investigate educational attainment of children with Self-Limited Epilepsy with CentroTemporal Spi...
Cenobamate in adult patients with epilepsy and intellectual disability [0.03%]
克恩巴胺治疗癫痫伴智力障碍患者的疗效及安全性
David Steinbart,Rebekka Geelhaar,Rebekka Lehmann et al.
David Steinbart et al.
Objective: In people with intellectual disability (ID), prevalence of epilepsy is up to 50-times higher than in the general population and often difficult to treat. Multiple randomized controlled, observational and retros...
Seizure control, delivery, and neonatal outcomes in pregnant women with focal epilepsies: a prospective cohort study [0.03%]
局灶性癫痫孕妇的发作控制、分娩方式及新生儿结局：前瞻性队列研究
Shahla Melikova,Aytan Mammadbayli
Shahla Melikova
Objective: To prospectively investigate seizure control during pregnancy in women with focal epilepsies, to assess the impact of specific forms of focal epilepsy (FE) on delivery and neonatal outcomes, and to compare thes...
Shared and divergent neuromagnetic network signatures in childhood absence epilepsy and self-limited epilepsy with centrotemporal spikes [0.03%]
儿童失神癫痫和限局性中央中颞区棘波自限性癫痫的共有及特有神经磁共振网络标志物
Yingfan Wang,Minghao Li,Xu Huang et al.
Yingfan Wang et al.
Objectives: Childhood Absence Epilepsy (CAE) and Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) are common, clinically associated syndromes, yet their shared and distinct pathophysiological mechanisms remain u...
Rekha Dwivedi,Yogendra Kumar Gupta,Meenakshi Singh et al.
Rekha Dwivedi et al.
Asymmetry in the diffusion tensor image analysis along the perivascular space index predicts seizure outcome in MRI-negative focal epilepsy [0.03%]
基于弥散张量成像的血管周围空间指数在MRI阴性的局灶性癫痫中的不对称性预测癫痫预后
Jungyon Yum,Wonwoo Lee,Woo-Seok Ha et al.
Jungyon Yum et al.
Purpose: We evaluated diffusion tensor image analysis along the perivascular space (DTI-ALPS) index asymmetry as an imaging correlate of glymphatic activity and its prognostic value in MRI-negative focal epilepsy. ...
Efficacy and safety of cenobamate in developmental and epileptic encephalopathies: A systematic review and meta-analysis [0.03%]
司来巴马治疗发育性和癫痫性脑病的疗效和安全性：系统评价和 meta 分析
Debopam Samanta,Sunil Naik
Debopam Samanta
Objective: To evaluate the efficacy and safety of cenobamate in developmental and epileptic encephalopathies (DEE) through systematic review and meta-analysis. ...
Raman Sankar,Louis Ferrari,Marc Kamin
Raman Sankar
Antiseizure medications have varied effects on neurotransmitter receptors and ion channels in the brain, yet how these mechanisms of action (MoAs) translate to clinical efficacy is not well understood. Cenobamate, a tetrazole alkyl carbamat...
The structure-function dissociation in mesial temporal lobe epilepsy with temporopolar blurring [0.03%]
内侧颞叶癫痫伴颞极结构异常的功能联系脱钩现象
Yuming Li,Peiwen Liu,Qiuxing Lin et al.
Yuming Li et al.
Objectives: While ipsilateral temporopolar blurring (TPB) has been associated with white matter degeneration in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), its influence within the large-scale neural netwo...