Repurposed Axitinib delivered via lipid-extruded PEGylated liposomes: 2D/3D breast cancer cell evaluation and in-vivo pharmacokinetics [0.03%]
经脂质提取的PEG化脂质体递送再利用的Axitinib：二维和三维乳腺癌细胞评价及体内药代动力学研究
Avinash Pawar,Ekta Pardhi,Sumedh Bahadure et al.
Avinash Pawar et al.
PEGylated liposomal nanocarriers have emerged as a promising drug delivery platform for improving the pharmacokinetic performance and systemic circulation of poorly water-soluble anticancer drugs. In this study, Axitinib-loaded PEGylated li...
CS-PEG-modified long-circulating tanshinone I liposomes for enhanced lipid-lowering synergy with atorvastatin and reduced adverse effects [0.03%]
用于增强与阿托伐他汀协同降脂作用及减少不良反应的CS-PEG修饰的丹参酮Ⅰ长循环脂质体
Li Zhang,Yize Lv,Xuedi Weng et al.
Li Zhang et al.
Chitosan-polyethylene glycol (CS-PEG)-modified long-circulating liposomes were developed and loaded with tanshinone I (TaI@CS-PEG-L) to overcome its poor solubility and low bioavailability, as well as enhance the lipid-lowering efficacy of ...
A quality-by-design engineering strategy for hybrid lipid-random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies [0.03%]
一种针对混合脂质-随机共聚物纳米粒子优化的基于质量的设计工程策略：甲氨蝶呤负载及疗效研究
Efstathia Triantafyllopoulou,Ilias Papantzimas,Anastasia Balafouti et al.
Efstathia Triantafyllopoulou et al.
The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictabil...
A novel quantification method for unencapsulated doxorubicin in tissues: unlocking PK/PD and TK/TD insights for pegylated liposomal doxorubicin [0.03%]
一种组织中未包裹多柔比星的新定量方法：为聚乙二醇化脂质体多柔比星解锁药代动力学/药物动力学和药代毒理学/毒性动态学见解的方法
Koki Narimatsu,Masahiro Yahata,Mei S Yamaguchi et al.
Koki Narimatsu et al.
Pegylated liposomal doxorubicin (PLD) is the first FDA-approved liposomal product in the oncology field and has been extensively investigated over the years. Although PLD has been extensively studied, measurement of unencapsulated doxorubic...
Carbon monoxide-releasing vesicles provide rapid and sustained inhibition of inflammatory pain in mice [0.03%]
载一氧化碳囊泡可快速持久地抑制小鼠炎症痛
Alejandra Bárcena-Esplá,Mario López-Martín,Sylmara Esther Negrini-Ferrari et al.
Alejandra Bárcena-Esplá et al.
Carbon monoxide (CO) is an important modulator of chronic pain, but its clinical use remains limited. To enhance its therapeutic potential, we developed a vesicular CO-releasing system based on a carbonyl metallosurfactant (PCOL6) and soy p...
Harnessing Box-Behnken design to optimize erlotinib-niclosamide co-loaded liposomes, overcoming EGFR-mutated lung cancer resistance, and improving sensitivity via EGFR/STAT3 signaling pathway [0.03%]
利用Box-Behnken设计优化厄洛替尼-尼克利胺共载脂质体，克服EGFR突变型肺癌的耐药性，并通过EGFR/STAT3信号通路提高敏感性
Amruta Prabhakar Padakanti,Mythri Chandrasekaran,Suchita Shalini et al.
Amruta Prabhakar Padakanti et al.
The co-administration of niclosamide (NCM) with erlotinib hydrochloride (ERL) has been shown to restore ERL sensitivity in resistant non-small cell lung cancer. However, the poor physicochemical properties of both molecules necessitate a sp...
Phytosterol ester-based liposomes for improved oral delivery of puerarin: enhanced stability and mucus penetration [0.03%]
基于植物甾醇酯的脂质体递送紫花前胡素：提高口服给药稳定性及黏附性
Pu Yang,Xiqi Wu,Jingjian Liu et al.
Pu Yang et al.
Puerarin (Pue), an isoflavone with diverse pharmacological activities, exhibits poor oral bioavailability due to its low solubility and permeability. To improve its oral delivery, phytosterol ester (PE) was employed as a membrane stabilizer...
Ultrasound-responsive drug nanocarriers in oncology: key determinants of therapeutic performance [0.03%]
声响应药物纳米递送系统在肿瘤学中的应用：治疗性能的关键因素
Fahima Reete,Zimei Wu,Sachin S Thakur
Fahima Reete
Carrier-based systems, particularly liposomes, continue to be widely investigated for delivering anticancer treatments. In recent years, multiple approaches have been explored to achieve on-demand delivery of therapeutic cargo from these sy...
Transnasal Zolmitriptan-Ginkgolide B loaded liposomes for migraine therapy: formulation, optimisation and in vitro characterisation [0.03%]
载有佐米曲普坦-银杏内酯B的鼻用脂质体递药体系治疗偏头痛：处方、优化及体外性能研究
Aparna Rajesh,Abhirami Subramony,Nethish Kumaar R et al.
Aparna Rajesh et al.
Migraine is a chronic neurological disorder that necessitates swift and efficient treatment. Zolmitriptan (ZMT) is a first-line agent with low oral bioavailability and a slow onset of action. Intranasal delivery represents one of the noninv...
Liposomes in oral delivery: mechanisms, advances, challenges, and future perspectives [0.03%]
口服给药的脂质体：机制、进展、挑战和未来展望
Patrick Pan,Yuhong Ma,Seeun Kong et al.
Patrick Pan et al.
Oral liposome drug delivery system has gained attention due to their potential to improve patient compliance, enhance the bioavailability of encapsulated poorly soluble drugs, and protect drugs from gastrointestinal degradation. Liposomes s...