Biophysical and biological evaluation of free and liposomal doxorubicin and β-carotene reveals enhanced therapeutic selectivity in MCF-7 breast cancer cells [0.03%]
生物物理和生物学评价表明与阿霉素和β-胡萝卜素相比，脂质体阿霉素对MCF-7乳腺癌细胞的治疗具有更高的选择性
Hany M A Elrahman,Medhat W Shafaa,Michael Masoomi et al.
Hany M A Elrahman et al.
Breast cancer remains a major health challenge, highlighting the need for more effective and safer therapies. Although doxorubicin is widely used, its clinical utility is limited by oxidative stress-induced toxicity. This study investigated...
Marwa H Elkarmalawy,Marwa M Nagib,Amany Belal et al.
Marwa H Elkarmalawy et al.
Breast cancer (BC) represents a serious threat to public health worldwide, especially for women. Anastrozole (ATZ) is recognized as a therapeutic candidate for treating BC. However, its poor solubility and bioavailability result in low effi...
Nanoliposomes based drug delivery for the treatment of various types of cancers: current trends and future perspectives [0.03%]
基于纳米脂质体的癌症治疗药物递送系统：现状和未来展望
Binapani Barik,Tahreen Taj,Rabab Fatima et al.
Binapani Barik et al.
Multifunctional lipid-based nanoparticles, like nanoliposomes (NLPs), effectively deliver therapeutic and diagnostic functions, with recent modifications to liposomes reducing toxicity to human cells. These NLPs and micelles enhance therape...
Effect of cationic amphiphilic drugs on mRNA lipoplex-induced protein expression [0.03%]
阳离子两亲性药物对mRNA脂质复合物介导的蛋白质表达的影响
Yoshiyuki Hattori,Hayato Kawasaki,Maya Nishiyama et al.
Yoshiyuki Hattori et al.
In this study, we investigated the impact of cationic amphiphilic drugs (CADs) on in vitro and in vivo protein expression following administration of mRNA lipoplexes. The mRNA lipoplexes were formulated using a modified ethanol injection me...
Microneedle assisted drug delivery of liposome loaded with selegiline hydrochloride for effective management of Parkinson's disease intervention [0.03%]
富左旋多巴脂质体的微针透皮给药系统用于帕金森病的治疗研究
Kartik Bhairu Khot,Jobin Jose,Gopika Gopan et al.
Kartik Bhairu Khot et al.
Microneedles assisted transdermal delivery of cationic liposomes loaded with selegiline hydrochloride is an innovative approach to treat the symptoms of Parkinson's disease. Previously optimized liposomes of selegiline hydrochloride (SH-LP3...
Liposomal iron bisglycinate hydrochloride, but not free iron bisglycinate, enhances serum iron restoration in a mouse model of inflammation-induced anemia: a preliminary study [0.03%]
铁蛋白型甘氨酸铁氯化物而非游离甘氨酸铁能够促进炎症性贫血小鼠模型中铁水平的恢复：一项初步研究
Meygal Kahana Sela,Amir Agbaria,Noor Omari Knani et al.
Meygal Kahana Sela et al.
Iron deficiency is a major global health concern, particularly in inflammation-related anemia (IRA), where iron absorption and mobilization are impaired. Liposomal encapsulation may help enhance the bioavailability and efficacy of iron supp...
A mechanistic study of mitochondria-targeted PCSK9 liposomes attenuate oxidative damage in carotid artery plaques [0.03%]
一种针对颈动脉斑块的线粒体靶向PCSK9脂质体的抗氧化作用及机制研究
Liwei Zhang,Guanyu Chen,Yuhai Bai et al.
Liwei Zhang et al.
Atherosclerotic plaque instability is a direct cause of cardiovascular and cerebrovascular events. In this study, a mitochondria-targeted liposome (LIP), modified with triphenylphosphonium (TPP) to enable specific mitochondrial delivery, wa...
Impact of cationic:helper lipid ratios and PEG-lipid architecture on siRNA delivery performance of 2X3-based liposomal formulations [0.03%]
阳离子：辅助脂质比例和PEG脂质结构对基于2X3的liposomal制剂的siRNA递送性能的影响
Daniil V Gladkikh,Elena V Shmendel,Mikhail A Maslov et al.
Daniil V Gladkikh et al.
Small interfering RNA (siRNA) therapeutics hold great potential for treating genetic disorders and cancer, yet their clinical translation remains constrained by the challenge of efficient delivery. This study systematically investigates the...
Development of immunoliposomes with E-Selectin affinity to target endothelial inflammation: direct comparison of antibody types [0.03%]
针对血管炎症的免疫脂质体的开发：不同类型抗体的直接比较研究
Foteini Gkartziou,Valérie Petegnief,Maria Kannavou et al.
Foteini Gkartziou et al.
Inflamed endothelium targeting via E-Selectin is a promising strategy for drug delivery across the neurovascular interface, however, exploitation of the strategy by immunoliposomes remains limited. Furthermore, the high cost of antibodies p...