Design, synthesis, and molecular docking evaluation of novel pyrimidine-thiadiazole glycosides as potential anticancer agents [0.03%]
Amira A Ghoneim,Abdullah Y Abdullah Alzahrani,Wassila Derafa et al.
Amira A Ghoneim et al.
A series of novel pyrimidine-thiadiazole conjugates incorporating carbohydrate-based 1,3,4-thiadiazole thioglycosides were synthesized and analyzed using (IR), (1H-NMR) and (13C-NMR) spectroscopy. The synthesized compounds were evaluated fo...
miR-769-5p inhibits cellular behaviors associated with endometriosis progression by directly targeting follistatin in vitro [0.03%]
miR-769-5p通过直接靶向卵泡刺激素在体外抑制与子宫内膜异位症进展相关的细胞行为
Yibo Meng,Qinghua Chen,Han Lu
Yibo Meng
The pathogenesis of endometriosis (EM) remains intricate and multifactorial. This study aimed to investigate the biological functions of microRNA-769-5p (miR-769-5p) in an in vitro model of EM. Serum was obtained from 120 EM patients and 10...
d-Alanyl:d-alanine ligase inhibitors as antibacterial agents against Staphylococcus aureus: a review [0.03%]
针对金黄色葡萄球菌的d-丙氨酰-d_丙氨酸连接酶抑制剂抗菌药物的研究进展综述
Mohammed Afzal Azam,Abisha Thomas,Srikanth Jupudi
Mohammed Afzal Azam
Gram-positive pathogen Staphylococcus aureus is associated with human mortality and morbidity worldwide. Mutants of this pathogen is responsible for life threatening community-associated meticillin-resistant infections. Further, the evoluti...
Synthesis, structural elucidation, DNA binding, cleavage, cholinesterase inhibitory activity of metal complexes of novel 2,2'-bipyridyl derivative [0.03%]
新型2,2'-联吡啶衍生物金属配合物的合成、结构解析、DNA结合及切割、胆碱酯酶抑制活性研究
Ebenezer Bonpandi,Caroline John,Pechiammal Arumugam
Ebenezer Bonpandi
To achieve efficient cholinesterase inhibitory activity of metal(II) complexes of Cu(II), Ni(II), Co(II), and Zn(II) with 2,2'-bipyridyl framework [M-L] (L = 2,2'-bipyridyl derivative containing an aromatic center and an e--withdrawing -NO2...
miR-1247-5p is correlated with cervical cancer and regulates cervical cancer cell functions by targeting DVL1 [0.03%]
miR-1247-5p与宫颈癌相关并通过靶向DVL1调控宫颈癌细胞功能
Yuhua Yan,Jing Li,Cuiya Zhang et al.
Yuhua Yan et al.
The incidence of cervical cancer (CC) is extremely high, yet current diagnostic biomarkers have not achieved satisfactory results. MicroRNAs can regulate vital processes in tumors, including proliferation and apoptosis. The regulatory role ...
Integrating multi-encoding sequence features via stacking ensemble learning for RNA m5C site prediction [0.03%]
基于堆叠集成学习的RNA甲基化位点预测方法
Ubaid Ur Rahman,Naeem Ul Islam
Ubaid Ur Rahman
RNA 5-methylcytosine (m5C) is an important epitranscriptomic modification involved in RNA stability, translation, and post-transcriptional regulation. Accurate identification of m5C sites remains challenging due to limited sequence represen...
CRISPR Cas9 mediated genome editing to induce apoptosis a new strategy to tackle cancer [0.03%]
利用CRISPR-Cas9基因编辑诱导癌细胞凋亡：治疗癌症的新策略
Saqib Hussain Hadri,Faizan Ahmad,Ayesha Malik et al.
Saqib Hussain Hadri et al.
CRISPR-Cas9 is a strong gene editing tool having two components, Cas9 protein and guide RNA. It involves a protospacer adjacent motif (PAM) which is identified by Cas9 endonucleases to initiate double stranded break in DNA, which is repaire...
Post-COVID increase in N-methyl-2-pyridone-5-carboxamide (Met2PY) and N-methyl-4-pyridone-3-carboxamide (Met4PY) associates with inflammatory and endothelial activation markers [0.03%]
新冠肺炎后N-甲基-2-哒嗪-5-羧酰胺和N-甲基-4-哒嗪-3-羧酰胺水平升高与炎症及内皮激活标志物相关
Aleksandra Jóźwiak,Adela Lewandowska,Dominika Sawicka et al.
Aleksandra Jóźwiak et al.
COVID-19 is associated with long-term vascular complications, but the underlying mechanisms remain incompletely understood. During infection, NAD+ homeostasis becomes dys-regulated, with excessive NAD+ consumption and enhanced catabolic flu...
Suppression of PANC-1 pancreatic cancer cell proliferation by gemcitabine and ultrasound-mediated microbubble therapy [0.03%]
吉西他滨和超声介导的微泡联合疗法对PANC-1胰腺癌细胞增殖的抑制作用
Sila Appak-Baskoy,Zlatina Naydenova,Mathew Rajic et al.
Sila Appak-Baskoy et al.
Pancreatic ductal adenocarcinoma (PDAC) is among the most treatment-resistant malignancies, characterized by aggressive progression and limited drug penetration reducing chemotherapeutic efficacy. Gemcitabine, a pyrimidine nucleoside analog...
Deoxycytidine kinase inhibition: Rewiring tumor nucleotide metabolism for therapeutic gain [0.03%]
脱氧胞苷激酶抑制作用：重新连线肿瘤核苷酸代谢以获得治疗收益
Peter M Clark,Curtis B Thompson,Kenneth A Schultz
Peter M Clark
Deoxycytidine kinase (dCK) is the rate-limiting enzyme of the deoxyribonucleoside salvage pathway, phosphorylating deoxyadenosine, deoxycytidine, and deoxyguanosine to sustain intracellular deoxyribonucleoside triphosphate (dNTP) pools. Rep...