Partial base pairing between 5' and 3' UTRs artificially regulates IVT mRNA expression levels [0.03%]
5'和3'UTR之间的部分碱基配对可人工调节体外转录mRNA的表达水平
Nao Hosoda,Atsushi Takasu,Kohei Nakanishi et al.
Nao Hosoda et al.
Eukaryotic mature mRNAs possess a 5' cap and a 3' polyadenylate tail (poly(A)), both of which are essential for regulating mRNA expression levels. This regulation is structurally based on the circularization of mRNA, mediated by physical in...
LncRNA EGOT inhibits the proliferation of lung adenocarcinoma cells and is associated with poor prognosis [0.03%]
长链非编码RNA EGOT抑制肺腺癌细胞增殖并与预后不良相关
Yi Ming Sheng,Ke Qiang Wang,Hu Nan Huang et al.
Yi Ming Sheng et al.
Long non-coding RNA (lncRNA) EGOT is dysregulated in multiple malignancies and participates in tumor progression. Its role and mechanism in lung adenocarcinoma (LUAD) were unclear. The present study set out to investigate the expression pat...
Can the combination of 5-fluorouracil and gemcitabine increase the treatment efficacy of pancreatic and colon cancer? [0.03%]
5-氟尿嘧啶与吉西他滨联合使用能否提高胰腺癌和结肠癌的治疗效果？
Marika A Franczak,Ryszard T Smolenski,Elizabeth C Comijn et al.
Marika A Franczak et al.
Pancreatic ductal adenocarcinoma (PDAC) is intrinsically drug-resistant. Combinations of 5-fluorouracil (5-FU) with other cytostatics in FOLFIRINOX and gemcitabine (Gem) with nab-paclitaxel are first-line treatments. Colorectal cancer (CRC)...
"Aptamer-guided therapeutics and diagnostics for metabolic syndrome: Design, delivery, and translation of aptamer-based systems" [0.03%]
代谢综合征的适配体导向治疗和诊断：基于适配体系统的设计、递送及转化研究
Ameena Ahmed,Manash Pratim Pathak
Ameena Ahmed
Metabolic syndrome (MetS) is a composite cardiometabolic condition defined by visceral obesity, dyslipidemia, hypertension, and insulin resistance, and it promotes the worldwide prevalence of type 2 diabetes and atherosclerotic cardiovascul...
The impact of vitamin B12 deficiency on urinary profile of de novo purine synthesis intermediates: consequences of the methylfolate trap [0.03%]
维生素B12缺乏对尿液嘌呤合成中间产物的影响：“甲基四氢叶酸陷阱”的后果
Jakub Krijt,Václava Škopová,Jitka Sokolová et al.
Jakub Krijt et al.
Vitamin B12 (B12) deficiency may cause severe clinical complications, partly attributable to the "methylfolate trap". When B12-dependent methionine synthase activity is impaired, 5-methyltetrahydrofolate (5-MTHF) becomes trapped because it ...
Evaluation of MTH1 and DCTPP1 inhibitors in fluorocyclopentenylcytosine (RX-3117) resistant lung cancer cells and potential cross resistance patterns [0.03%]
氟环戊烯胞苷(RX-3117)耐药肺癌细胞中MTH1和DCTPP1抑制剂活性评价及其潜在交叉耐药模式分析
Djzemma Sarkisjan,Safet Zekanovic,Beatrice Balboni et al.
Djzemma Sarkisjan et al.
Fluorocyclopentenylcytosine (RX-3117) is a nucleoside analog developed to bypass gemcitabine resistance. We developed several fluorocyclopentenylcytosine- and gemcitabine-resistant non-small cell lung cancer (NSCLC) cell lines, which showed...
Circular RNAs: promising biomarkers for diagnosis, prognosis and therapy in oral squamous cell carcinoma [0.03%]
循环RNA作为口腔鳞状细胞癌诊断、预后和治疗的潜在生物标志物
Atika Dogra,Samson Mani,Yasha Hasija
Atika Dogra
Circular RNAs (circRNAs) have arisen as a new area of interest among non-coding RNAs in cancer. Increased stability, abundance in human cells, tissue specificity, and regulatory functions in various diseases including cancer indicate that c...
Aleena Taufiq,Sajad Ahmad Dar,Saurabh Singh et al.
Aleena Taufiq et al.
Neurodegenerative diseases are associated with progressive neural malfunction, which is driven by common molecular pathologies that encompass protein aggregations, mitochondrial dysfunction, aberrant RNA metabolism and impaired intracellula...
Design, synthesis, and molecular docking evaluation of novel pyrimidine-thiadiazole glycosides as potential anticancer agents [0.03%]
新型嘧啶-噻二唑糖苷作为潜在抗肿瘤剂的设计、合成及分子对接评价
Amira A Ghoneim,Abdullah Y Abdullah Alzahrani,Wassila Derafa et al.
Amira A Ghoneim et al.
A series of novel pyrimidine-thiadiazole conjugates incorporating carbohydrate-based 1,3,4-thiadiazole thioglycosides were synthesized and analyzed using (IR), (1H-NMR) and (13C-NMR) spectroscopy. The synthesized compounds were evaluated fo...
miR-769-5p inhibits cellular behaviors associated with endometriosis progression by directly targeting follistatin in vitro [0.03%]
miR-769-5p通过直接靶向卵泡刺激素在体外抑制与子宫内膜异位症进展相关的细胞行为
Yibo Meng,Qinghua Chen,Han Lu
Yibo Meng
The pathogenesis of endometriosis (EM) remains intricate and multifactorial. This study aimed to investigate the biological functions of microRNA-769-5p (miR-769-5p) in an in vitro model of EM. Serum was obtained from 120 EM patients and 10...