Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins [0.03%]
妊娠糖尿病与胰岛素样生长因子生物利用度及其结合蛋白的关系
Kateřina Anderlová,Anna Cinkajzlová,Patrik Šimják et al.
Kateřina Anderlová et al.
Objective: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase insulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GD...
Effects of 18 months of GH replacement on cardiovascular risk factors and quality of life in GH deficient adults; a randomized controlled trial using a fixed very low and a standard dose of GH [0.03%]
一项随机对照研究：生长激素缺乏成人用固定低剂量及标准剂量生长激素替代治疗18个月对心血管危险因素和生活质量的影响
Galina Götherström,Gudmundur Johannsson,Johan Svensson
Galina Götherström
Objective: Little is known of the effects of a fixed very low dose of growth hormone (GH) replacement on cardiovascular risk factors, bone mass, muscle strength and quality of life (QoL) in hypopituitary patients. ...
Paradoxical GH increase during oral glucose load may predict overall remission in acromegalic patients [0.03%]
口服葡萄糖负荷期间生长激素的反常升高可预测肢端肥大症患者的总体缓解率
Hakan Düğer,Hayri Bostan,Hilal Yıldırım Deryol et al.
Hakan Düğer et al.
Background: The nadir growth hormone (nGH) during the oral glucose tolerance test (OGTT) is the gold standard method for diagnosing acromegaly. A paradoxical growth hormone (GH) response to oral glucose (OG) in acromegaly...
Increase of serum lipoprotein (a), an adverse effect of growth hormone treatment [0.03%]
生长激素治疗的一个不良反应：增加血清脂蛋白(a)水平
Zvi Laron
Zvi Laron
A number of reports show that high endogenous, or therapeutic administration of human growth hormone (hGH) cause an increase of serum lipoprotein a, Lp(a). Being thrombogenic Lp(a) is an independent risk factor of atherosclerotic cardiovasc...
Age, GH/IGF-1 levels, tumor volume, T2 hypointensity, and tumor subtype rather than proliferation and invasion are all reliable predictors of biochemical response to somatostatin analogue therapy in patients with acromegaly: A clinicopathological study [0.03%]
生长激素/胰岛素样生长因子-1水平、肿瘤体积、T2低信号和肿瘤亚型而非增殖和侵袭都是肢端肥大症患者接受生长抑素类似物治疗的生化反应的可靠预测因素：一项临床病理学研究
Elif Tutku Durmuş,Ayşegül Atmaca,Mehmet Kefeli et al.
Elif Tutku Durmuş et al.
Purpose: To determine whether biochemical responses to long-acting forms of first-generation somatostatin analogue (SSA) therapy in patients with acromegaly could be predicted from baseline and postoperative hormone conce...
Pharmacokinetics and pharmacodynamics of once-weekly administration of JR-142, a long-acting albumin-fused human growth hormone: A rondemized, placebo-controlled phase 1 study [0.03%]
每周一次注射长效人重组生长激素与白蛋白融合蛋白(JR-142)的药代动力学及药效学：一项随机双盲安慰剂对照I期临床试验
Yasuko Owada,Mika Okazaki,Toshiaki Ikeda et al.
Yasuko Owada et al.
Objective: Under clinical development for patients with growth hormone deficiency, JR-142 is a long-acting growth hormone with a half-life extended by fusion with modified serum albumin. We conducted a Phase 1 study to in...
The regulation of proliferation and apoptosis in hepatocellular carcinoma via insulin-like growth factor 1 receptor [0.03%]
胰岛素样生长因子1受体在肝癌增殖和凋亡中的作用及机制研究
Guanjun Xu,Jiesheng Chu,Yu Shi et al.
Guanjun Xu et al.
Objectives: Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase receptor of the insulin receptor family. Its expression is consistently increased in hepatocellular carcinoma (HCC) tissue, and...
Growth hormone inhibits adipogenic differentiation and induces browning in bovine subcutaneous adipocytes [0.03%]
生长激素通过抑制牛皮下脂肪细胞的成脂分化和促进褐变来减少脂肪生成
Tingting Li,Hui Bai,Haoyuan Fang et al.
Tingting Li et al.
Objective: It is well established that growth hormone (GH) has the ability to stimulate lipolysis. The effects of GH on adipocyte differentiation and browning have not been clearly described. Therefore, the present study ...
Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly? [0.03%]
神经类固醇对肢端肥大症患者的抑郁症和认知功能有影响吗？
Esra Hatipoglu,Yalcin Hacioglu,Yeliz Polat et al.
Esra Hatipoglu et al.
Objective: Neurosteroids (NSs) are a distinct hormone group and, they are known for their contribution into the status of mood and cognitive functions. Whether they are also involved in the mood disturbances and cognition...
A consensus on optimization of care in patients with growth hormone deficiency and mild traumatic brain injury [0.03%]
生长激素缺乏合并轻度创伤性脑损伤患者的治疗优化共识
Kevin C J Yuen,Brent Masel,Michael S Jaffee et al.
Kevin C J Yuen et al.
Objective/design: Approximately 2.9 million children and adults in the US experience traumatic brain injuries (TBIs) annually, most of which are considered mild. TBI can induce varying consequences on pituitary function, ...