Growth hormone - releasing hormone antagonists induce autophagy in cancer cells [0.03%]
生长激素释放肽受体拮抗剂通过自噬诱导杀死肿瘤细胞
Madan Sigdel,Saikat Fakir,Md Matiur Rahman Sarker et al.
Madan Sigdel et al.
GHRH antagonists (GHRHAnt) were developed to suppress cancers and have been associated with robust anti-inflammatory and anti-oxidative activities. The mechanisms involved in those effects are not completely understood. MDA-MB-468 and A549 ...
Effects of insulin-like growth factor-I and Progranulin on a human trophoblast model [0.03%]
胰岛素样生长因子-I和前列腺素对人类胎盘滋养层模型的影响
Makoto Osaka,Atsushi Tajima,Satoshi Takemori et al.
Makoto Osaka et al.
Gestational diabetes and obesity are associated with increased placental weight and fetal birth weight. Placental development is mainly promoted by trophoblast proliferation and various humoral factors. Insulin-like growth factor-1 (IGFI) l...
Dose optimization of PEG-rhGH therapy to improve growth outcomes of childhood-onset growth failure [0.03%]
PEG-rhGH治疗剂量优化可改善儿童期生长激素缺乏的生长结局
Ying Wu,Lai Zhang,Haipeng Ma et al.
Ying Wu et al.
Background: This study evaluates the efficacy and safety of optimized PEG-rhGH dosing in pre-pubertal and pubertal children with Childhood-Onset Growth Failure due to growth hormone deficiency (GHD) or non-GHD causes. ...
Administration study of somapacitan, a long-acting growth hormone derivative, in horse for doping control purpose [0.03%]
用于反兴奋剂目的的生长激素衍生物somapacitan在马身上的管理研究
Yoshibumi Shimizu,Michiko Sugai-Bannai,Haruka Tanabe et al.
Yoshibumi Shimizu et al.
Somapacitan is the second generation of recombinant human growth hormone (rhGH) medication that retains the pharmacological effects of rhGH but exhibits a longer duration of action due to its reversible albumin-binding in the body. In gener...
Injection of lentiviral vectors expressing GH and IGF1 increases body and muscle mass in male rats [0.03%]
注射表达GH和IGF1的慢病毒载体可以增加雄性大鼠体重和肌体重
Zahra Roudbari,Akram Alizadeh,Mohammadreza Nassiri et al.
Zahra Roudbari et al.
The aim of this study was to increase growth hormone (GH1) and insulin-like growth factor-1 (IGF1) levels in rat muscle indirectly through the transduction of C2C12 cells via lentivectors and to compare their effects on muscle mass. The cod...
Efficacy, safety, and outcomes of growth hormone treatment in children with idiopathic short stature [0.03%]
生长激素治疗儿童特发性矮身材的疗效、安全性和结局研究
Agnès Linglart,Andrew Dauber,Alexander de Lima Jorge et al.
Agnès Linglart et al.
Background: Growth hormone (GH) is a treatment option in some countries for children with idiopathic short stature (ISS) given to enable them to attain height within the expected range. Currently, it is not often utilised...
Growth hormone regulates deiodinase type 2 and 3 expression via GATA [0.03%]
生长激素通过GATA调节脱碘酶类型2和3的表达
Mana Mitsutani,Hiromi Hano,Mei Yokoyama et al.
Mana Mitsutani et al.
Objective: Growth hormone (GH) is involved in bone and skeletal muscle growth directly or indirectly via STAT5 and/or insulin-like growth factor (IGF)-1. Thyroid hormone (TH) is essential for general cellular growth and m...
Impact of disease activity on cognitive and psychological outcomes in acromegaly: A prospective study [0.03%]
肢端肥大症疾病活动对认知和心理结果的影响：一项前瞻性研究
Serhat Uysal,Zehra Kara,Cem Sulu et al.
Serhat Uysal et al.
Purpose: To investigate the cognitive and psychological aspects of acromegaly and to assess how disease activity may affect these outcomes. Methods: ...
Corrigendum to "Pharmacodynamics, pharmacokinetics, and toxicology of Fc-growth hormone fusion protein in macaques" [0.03%]
有关“人Fc-生长激素融合蛋白在食蟹猴体内的药动学、药效学及毒性研究”的勘误页
Han Liu,Binghuai Peng,Baisong Zhou et al.
Han Liu et al.
Pharmacodynamics, pharmacokinetics, and toxicology of Fc-growth hormone fusion protein in macaques [0.03%]
Fc-生长激素融合蛋白在猕猴中的药效学、药代动力学和毒理学研究
Han Liu,Binghuai Peng,Baisong Zhou et al.
Han Liu et al.
Purpose: Growth hormone (GH) therapy for GH deficiency is used to treat multiple conditions. However, the short half-life of GH necessitates frequent dosing, which limits patient adherence. Fc fusion proteins, created by ...