Dose optimization and safety of long-acting pegylated growth hormone in pubertal idiopathic short stature: A retrospective real-world group study [0.03%]
一项关于青春期特发性身材矮小患者长期使用长效聚乙二醇重组人生长激素的回顾性真实世界研究：剂量优化和安全性研究
Jiayi Wu,Lan Wang,Qun Jiang
Jiayi Wu
Purpose: Given the lack of established dosing strategies for polyethylene glycol recombinant long-acting human growth hormone (PEG-rhGH) in pubertal patients with idiopathic short stature (ISS), it is necessary to develop...
Real world data on rhIGF-1 therapy in children with severe primary IGF-I deficiency - The European experience [0.03%]
rhIGF-1治疗严重原发性IGF-I缺乏儿童的真实世界数据——欧洲经验
Jannette Saavedra,Peter Bang
Jannette Saavedra
The Growth Hormone - Insulin-like Growh Factor - axis promotes linear growth in children and adolescents and accounts for approximately 1/3 of adult height. In Primary IGF-I deficiency (PIGFD) insensitivity to the actions of GH results in s...
Effects of switching from somatropin to somapacitan on thyroid hormone levels in adult growth hormone deficiency: A pilot study [0.03%]
从生长激素替代疗法 SWITCH 至索马佩坎坦对成人生长激素缺乏症患者甲状腺素水平影响的探索性研究
Yuki Tsujimoto,Kenji Yamashiro,Yuki Suzuki et al.
Yuki Tsujimoto et al.
Adult growth hormone deficiency (AGHD) is associated with altered body composition, reduced quality of life, and increased cardiovascular risk, which can be mitigated by growth hormone (GH) replacement. Recently, once-weekly somapacitan has...
Prognostic value of immediate and short-term postoperative biochemical markers for long-term remission in acromegaly: A single-center study [0.03%]
生长激素瘤术后即刻和短期生化指标对长期缓解的预后价值：单中心研究
Tzu-Hua Chen,Shyang-Rong Shih,Huan-Chih Wang et al.
Tzu-Hua Chen et al.
Purpose: This study aimed to identify clinical and biochemical predictors of short- and long-term surgical outcomes in patients with acromegaly, with a particular focus on postoperative risk stratification using a consens...
Extended follow-up is crucial for diagnosing growth hormone deficiency after traumatic brain injury in children and adolescents [0.03%]
延长随访对于诊断儿童和青少年创伤性脑损伤后的生长激素缺乏症至关重要
Geraldo Miranda Graca,Luiz Roberto Aguiar,Luiz De Lacerda
Geraldo Miranda Graca
Background: The rate of growth hormone (GH) deficiency (GHD) after traumatic brain injury (TBI) among children and adolescents remains uncertain, partly because of limited follow-up. ...
Real world performance of once weekly somatrogon on naive patients with isolated growth hormone deficiency: Mind the weight gain [0.03%]
一周一次的somatrogon在生长激素缺乏症初次治疗患者中的疗效和安全性：关注体重增加问题
Maria Moutafi,Georgia Sotiriou,Panagiota Triantafyllou et al.
Maria Moutafi et al.
Background: Growth hormone deficiency (GHD) is a common cause of short stature in children, associated with impaired growth and psychosocial challenges. Long-acting growth hormone (LAGH) formulations may reduce treatment ...
Andrew R Hoffman,Augusto Maldonado Gangotena
Andrew R Hoffman
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) production decline in conjunction with the catabolic changes seen in normal aging, a developmental stage that has been termed the somatopause. While GH-replacement therapy for the...
Paul H Saenger,Jorge Mejia-Corletto
Paul H Saenger
Alexander von Humboldt's early nineteenth-century explorations of the Andes established foundational methods in biogeography and environmental science, emphasizing measurement, spatial integration, and the interdependence of natural systems...
Is Somatrogon different? 6-month clinical outcomes and follow-up data in Turkish children transitioned from Somatropin to Somatrogon [0.03%]
索马特鲁gon与索马特罗相比如何？土耳其患儿从重组人生长激素转换为长效生长激素的临床结果及随访数据
Nurgul Atas,Rabia Deniz Kılçık,Fatoş Çirkin Melik et al.
Nurgul Atas et al.
Objective: Long-acting growth hormone (GH) formulations have been developed to reduce treatment burden and improve adherence in children with growth hormone deficiency (GHD). Somatrogon is a long-acting recombinant GH ana...
Growth hormone deficiency following traumatic brain injury in adults: Still much of a clinical enigma [0.03%]
成人脑外伤后生长激素缺乏仍是一个临床谜题
Kevin C J Yuen
Kevin C J Yuen
Traumatic brain injury (TBI) is a significant public health concern globally, contributing to substantial morbidity and mortality across all age groups. Clinical manifestations range from no symptoms to mild alterations of consciousness to ...