Increased levels of human placental growth hormone in the amniotic fluid of pregnancies affected by Down syndrome [0.03%]
Down综合征妊娠羊水中人胎盘生长激素水平升高
S Sifakis,E Papadopoulou,A Konstantinidou et al.
S Sifakis et al.
Objective: To evaluate the concentrations of human placental growth hormone (hPGH) in amniotic fluid (AF) at gestational mid-trimester in normal pregnancies and in pregnancies complicated by Down's syndrome. ...
The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women [0.03%]
生长激素对内脏脂肪质量的影响在男性中比雌激素缺乏的女性更明显
Celina Franco,Josef Koranyi,John Brandberg et al.
Celina Franco et al.
Context: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. ...
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models [0.03%]
生长激素/胰岛素样生长因子-1轴在寿命和健康跨度中的作用：动物模型的研究启示
Darlene E Berryman,Jens Sandahl Christiansen,Gudmundur Johannsson et al.
Darlene E Berryman et al.
Animal models are fundamentally important in our quest to understand the genetic, epigenetic, and environmental factors that contribute to human aging. In comparison to humans, relatively short-lived mammals are useful models as they allow ...
Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes [0.03%]
人未分化脂肪细胞向成熟脂肪细胞转化过程中胰岛素和IGF-I受体的变化
Karolina Bäck,Hans J Arnqvist
Karolina Bäck
Mature adipocytes originate from fibroblast-like precursor cells, preadipocytes, which differentiate to obtain the characteristics of adipocytes. Our aim was to investigate how differentiation of human preadipocytes affects the distribution...
Relationship between GH response and glycemic fluctuations in the glucagon stimulation test [0.03%]
胰升糖素刺激试验中GH分泌与血糖波动的关系
Fernando M A Giuffrida,Karina Berger,Lia Monte et al.
Fernando M A Giuffrida et al.
Objective: Verifying the association between glycemic fluctuation and GH response in the glucagon stimulation test. Basal evaluation of growth hormone (GH) has poor diagnostic accuracy due to its pulsatile secretion. GH-s...
Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects [0.03%]
长寿人群生长发育特点研究：新生儿IGF-Ⅰ与16岁晚青少年IGF-Ⅰ纵向队列研究
Anni Larnkjaer,Helga K Ingstrup,Lene Schack-Nielsen et al.
Anni Larnkjaer et al.
Background: IGF-I is a major regulator of growth, influenced primarily by diet in infancy and primarily by GH in childhood. Breastfed infants have lower IGF-I levels compared to formula fed and tend to be shorter. The hig...
Temporal and spatial expression of IGF-I and IGFBP-1 during acute-phase response induced by localized inflammation in rats [0.03%]
局部炎症诱发大鼠急性期反应过程中IGF-I和IGFBP-1的时空表达规律研究
R Novosyadlyy,A Lelbach,N Sheikh et al.
R Novosyadlyy et al.
Objective: The acute-phase response (APR), a cytokine-induced defense reaction of the body that enhances the innate immunity mechanisms directed to eliminate the noxious agent and restrict the area of damage, is accompani...
Developmental changes in insulin-like growth factor (IGF)-I and -II mRNA abundance in extra-embryonic membranes and small intestine of avian embryos [0.03%]
鸟类胚胎的卵黄囊和小肠中胰岛素样生长因子(Igf)-I和-Ii的mRNA表达量的变化规律研究
D M Karcher,J N Fleming-Waddell,T J Applegate
D M Karcher
Objective: Numerous researchers have evaluated the insulin-like growth factors (IGF) influence on mammalian fetal development. Although IGF has been explored in the avian system, questions remain on the role of IGF in avi...
A determination of the pre-analytical storage conditions for insulin like growth factor-I and type III procollagen peptide [0.03%]
生长激素前体III型procollagen肽和胰岛素样生长因子-I的储存条件研究
Richard I G Holt,Ioulietta Erotokritou-Mulligan,Sean A Ridley et al.
Richard I G Holt et al.
Objective: IGF-I and type III procollagen (P-III-P) have been proposed as markers to detect GH abuse. This study aims to determine whether the pre-analytical storage temperature or delayed centrifugation affect the measur...
New insulin-like growth factor (IGF)-precursor sequences from mammalian genomes: the molecular evolution of IGFs and associated peptides in primates [0.03%]
哺乳动物基因组中新的胰岛素样生长因子(IGF)前体序列：灵长类动物中IGFs及相关肽的分子进化
Michael Wallis
Michael Wallis
The insulin-like growth factors (IGF-I and IGF-II) and insulin are related proteins that play an important role in regulation of metabolism and growth. In mammals these proteins are generally strongly conserved, though the sequence of insul...