Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age [0.03%]
短胎龄儿身高偏矮与IGFBP-3基因多态性及血清中IGFBP-3水平的关系研究
D C M van der Kaay,A E J Hendriks,W A Ester et al.
D C M van der Kaay et al.
Context: IGF-I and IGFBP-3 play a central role in fetal and postnatal growth and levels are low in short SGA children. The -202 A/C and -185 C/T SNPs are located near elements involved in directing IGFBP3 promoter activit...
Short-term oral oestrogen therapy dissociates the growth hormone/insulin-like growth factor-I axis without altering energy metabolism in premenopausal women [0.03%]
短期雌激素疗法可使生长激素/胰岛素样生长因子I轴分离而不改变绝经前妇女的能量代谢
Denise S Huang,Anthony J O&#x;Sullivan
Denise S Huang
Objective: Oral oestrogen has been shown to dissociate the growth hormone (GH)/insulin-like growth factor (IGF)-I axis and alter energy metabolism in postmenopausal women. This study was designed to determine whether thes...
Effects of intermittent high-intensity exercise and carbohydrate supplementation on IGF-1 and glycogen of Wistar rats [0.03%]
不同间歇高强度运动结合碳水化合物补充对Wistar大鼠IGF-1和糖原的影响
Vivian Treichel Giesel,Mateus Reche,Lolita Schneider et al.
Vivian Treichel Giesel et al.
Objective: The aim of this study was to analyze the association between glucose infusion during intermittent physical exercise and its metabolic effects on rats. ...
Growth hormone deficient patients after traumatic brain injury--baseline characteristics and benefits after growth hormone replacement--an analysis of the German KIMS database [0.03%]
生长激素缺乏的脑外伤患者──基线特征和给予重组人生长激素替代治疗后的临床效益──德国KIMS数据库分析结果
I Kreitschmann-Andermahr,E M Poll,A Reineke et al.
I Kreitschmann-Andermahr et al.
Objective: In recent years, traumatic brain injury (TBI) has been identified as a significant cause of growth hormone deficiency (GHD). The aim of the present study was to characterize adult TBI patients with GHD to eluci...
Michael B Ranke,Anders Lindberg
Michael B Ranke
The use of growth hormone (GH) to treat children who have disturbances of growth is complicated by variability both within and across diagnostic groups, and at the start of and throughout treatment. Growth prediction models are important to...
Race/ethnic variation in serum levels of IGF-I and IGFBP-3 in US adults [0.03%]
美国成人中IGF-I和IGFBP-3的血清水平种族差异研究
David Berrigan,Nancy Potischman,Kevin W Dodd et al.
David Berrigan et al.
Objectives: The IGF axis plays a significant role in normal growth and development and variation in IGFs is associated with health outcomes. Past studies report variation in IGF levels among race/ethnic groups known to di...
Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice [0.03%]
胰岛素样生长因子通过抑制中性粒细胞的活化来减少应激诱导的胃黏膜损伤
Juan Zhao,Naoaki Harada,Kazuya Sobue et al.
Juan Zhao et al.
Objective: We previously reported that activated neutrophils are critically involved in the development of stress-induced gastric mucosal injury in mice. Caspase activation plays an important role in the pathogenesis of t...
Expression of ghrelin receptor, GHSR-1a, and its functional role in the porcine ovarian follicles [0.03%]
猪卵泡中胃泌素释放肽受体及其功能作用的表达研究
Agnieszka Rak,Dawid Szczepankiewicz,Ewa Łucja Gregoraszczuk
Agnieszka Rak
Recently, we reported stimulatory effect of ghrelin alone and in combination with growth hormone (GH) on estradiol secretion, aromatase activity in parallel with inhibitory effect on cell apoptosis. The aim of this study was to analyze the ...
Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels [0.03%]
结肠直肠组织胰岛素样生长因子系统各组分的表达及其与血清IGF水平的关系
Alina Vrieling,Dorien W Voskuil,Astrid Bosma et al.
Alina Vrieling et al.
Context: The insulin-like growth factor (IGF)-system has been implicated in colorectal tumor carcinogenesis. Although both tumor expression levels and serum concentrations of IGF-system components are related to colorecta...
Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH [0.03%]
健康青年男性rhGH治疗的血清IGF-Ⅰ水平及肌肉组织IGF-Ⅰ基因拼接型的研究
Michael Aperghis,Cristiana P Velloso,Mahjabeen Hameed et al.
Michael Aperghis et al.
Objective: Elevated growth hormone (GH) levels lead to increased circulating insulin-like growth factor-I (IGF-I), but the effects on localised muscle IGF-I splice variant expression is not known. The effects of rhGH admi...