Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption [0.03%]
生长激素受体基因缺陷雌鼠血液循环中生长激素对肌肉蛋白浓度的影响
William J Kraemer,Jakob L Vingren,Mark D Schuenke et al.
William J Kraemer et al.
Growth hormone (GH) is a potent secretague for circulating insulin-like growth factor-I (IGF-I). The purpose of this study was to examine the effect of circulating GH on muscle IGF-I protein expression using GH transgenic animal models. Thr...
Effect of environment on growth: auxological and hormonal parameters in African and Italian children [0.03%]
环境对生长的影响：非洲和意大利儿童的体质和激素参数
Mara Boschetti,Daniela Larizza,Valeria Calcaterra et al.
Mara Boschetti et al.
Objective: Genetic factors are the most important determinant of final height in developed countries, while in underprivileged countries food intake is crucial. Nutrients, in turn, may importantly affect IGF-IGFBP system ...
Insulin-like growth factor-I (IGF-I): solution properties and NMR chemical shift assignments near physiological pH [0.03%]
胰岛素样生长因子-I(IGF-I)：近生理pH值下的溶液性质及NMR化学位移分配
Zhihe Kuang,Shenggen Yao,Kerrie A McNeil et al.
Zhihe Kuang et al.
Objective: Insulin-like growth factor-I (IGF-I) plays important roles in normal growth and development, as well as in disease states, and its structure and function have been studied extensively using nuclear magnetic res...
Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH-IGF) axis gene expression in human fetal epiphyseal chondrocytes [0.03%]
维生素D和生长激素调节人胎儿干骺端软骨细胞中生长激素/胰岛素样生长因子轴基因的表达
M Fernández-Cancio,L Audi,A Carrascosa et al.
M Fernández-Cancio et al.
Objective: Cell proliferation and gene expression regulation were studied in human fetal epiphyseal chondrocytes to ascertain the involvement of GH-IGF axis components in human fetal growth regulation by 1,25-dihydroxyvit...
Lack of effect of IGF-I on the glomerular filtration rate in non-diabetic patients with advanced chronic kidney disease [0.03%]
IGF-I对非糖尿病晚期慢性肾脏病患者肾小球滤过率的影响较小
Ying Kuan,Joanne Surman,Jan Frystyk et al.
Ying Kuan et al.
Recombinant human insulin-like growth factor I (rhIGF-I) acutely increases the glomerular filtration rate (GFR) in human volunteers and patients with advanced chronic kidney disease (CKD). However, on chronic administration, rhIGF-I induces...
Comparison between weight-based and IGF-I-based growth hormone (GH) dosing in the treatment of children with GH deficiency and influence of exon 3 deleted GH receptor variant [0.03%]
基于体重和基于IGF-I的生长激素(GH)剂量在GH缺乏儿童治疗中的比较及外显子3缺失的GH受体变异体的影响
Frederico Guimarães Marchisotti,Alexander Augusto Lima Jorge,Luciana Ribeiro Montenegro et al.
Frederico Guimarães Marchisotti et al.
Objective: Compare the most frequently used weight-based GH dosing with an IGF-I level-based strategy in the treatment of children with severe GH deficiency. Additionally, analyse the influence of the GH receptor exon 3 p...
Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes [0.03%]
胰岛素样生长因子I比胰岛素更加有效地调节初级人肌细胞和肌管中的基因表达
Jane Palsgaard,Audrey E Brown,Maja Jensen et al.
Jane Palsgaard et al.
Conventionally, insulin is believed to induce a metabolic response, and IGF-I a mitogenic/differentiation response in vivo. However, several studies indicate that the roles of insulin and IGF-I may not be that easy to separate. In this stud...
Amino acid profiles in adults with growth hormone (GH) deficiency before and during GH replacement therapy [0.03%]
生长激素缺乏成人患者在补充治疗前后的氨基酸轮廓分布特征分析
R Fernholm,M Thoren,C Hoybye et al.
R Fernholm et al.
Objective: GH replacement to growth hormone deficient (GHD) adults improves body composition. In a subset however, lean body mass (LBM) fails to increase despite normalization of IGF-I and amino acid availability could be...
Ralf Nass,Gudmundur Johannsson,Jens S Christiansen et al.
Ralf Nass et al.
The expected increase in the aging population will have a significant impact on society and the health system in the coming years and decades. Enhancing healthspan, "healthy aging", and thus extending the time that the elderly are able to f...
S McLenachan,M-G Lum,M J Waters et al.
S McLenachan et al.
Objectives: Growth hormone (GH) and its receptor (GHR) are widely expressed in the CNS. During development, GH signaling regulates both proliferation of neural progenitor cells as well as their differentiation into neuron...