Reduced colonic apoptosis in mice overexpressing bovine growth hormone occurs through changes in several kinase pathways [0.03%]
过表达牛生长激素的小鼠结肠凋亡减少是通过几种激酶途径的变化实现的
Fausto Bogazzi,Federica Ultimieri,Francesco Raggi et al.
Fausto Bogazzi et al.
Objective: Growth hormone (GH) has antiapoptotic effects in several cell lines, including human colonic adenocarcinoma cells. In addition, it has been reported that patients with acromegaly have reduced apoptosis in colon...
IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children [0.03%]
生长迟缓儿童脂肪细胞中IGF-IR / ERK含量及其对IGF-I和胰岛素的反应
German Iñiguez,Paulina Ormazabal,Teresa López et al.
German Iñiguez et al.
Background/aims: The GH-IGF-I axis plays an important role on pre/postnatal growth in humans, and IGF-I regulates cell proliferation, differentiation, and metabolic homeostasis. The adipose tissue has an important functio...
Long-term physical training increases liver IGF-I in diabetic rats [0.03%]
长期的物理训练可以增加糖尿病大鼠肝脏中的IGF-I含量
J A C A Leme,R F Silveira,R J Gomes et al.
J A C A Leme et al.
Diabetes reduces the serum levels of insulin-like growth factor-I (IGF-I) and physical training may prevent this reduction. Almost all circulating IGF-I is produced and secreted by the liver. To examine the influence of moderate physical tr...
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers [0.03%]
安莫林（一种新型口服胃激素类似物和生长激素促分泌素）在健康志愿者中的药代动力学激素效应
José M Garcia,William J Polvino
José M Garcia
Objective: Activation of ghrelin receptors stimulates GH secretion and appetite, increasing lean body mass and body weight. However, clinical use of ghrelin is limited because it has a short half-life and must be administ...
Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system [0.03%]
生长激素(GH)和ghrelin在免疫系统中的表达、调控及生物学作用
Naoki Hattori
Naoki Hattori
Immune and neuroendocrine systems have bidirectional communications. Growth hormone (GH) and an orexigenic hormone ghrelin are expressed in various immune cells such as T lymphocytes, B lymphocytes, monocytes and neutrophils. These immune c...
Serum IGF-I and C-reactive protein in healthy black and white young men: the CARDIA male hormone study [0.03%]
卡迪亚男性激素研究中的健康黑白青年男性的IGF-Ⅰ和C反应蛋白水平比较
Laura A Colangelo,Brian Chiu,Peter Kopp et al.
Laura A Colangelo et al.
Objective: Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequat...
IGF-I replacement therapy in children with congenital IGF-I deficiency (Laron syndrome) maintains heart dimension and function [0.03%]
生长激素类似物疗法对拉龙病患儿心脏结构和功能的影响研究
Mickey Scheinowitz,Micha S Feinberg,Zvi Laron
Mickey Scheinowitz
Objective: Untreated patients with congenital growth hormone deficiency (GHD) and IGF-I deficiency are characterized not only by dwarfism but also by acromicria and organomicria, such as the heart. We assessed cardiac dim...
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction [0.03%]
亚临床甲状腺功能障碍患者的生长激素/胰岛素样生长因子轴异常
Fulya Akin,Guzin Fidan Yaylali,Sebahat Turgut et al.
Fulya Akin et al.
Objective: Our aim was to evaluate serum concentrations of GH, IGF-I, and insulin-like growth factor-binding protein-3 (IGFBP-3) in patients with subclinical thyroid dysfunction before and after normalization of thyroid f...
The effect of acute application of pegvisomant alone and in combination with octreotide on endogenous GH levels during a 6-h test in patients with acromegaly on constant pegvisomant treatment [0.03%]
pegvisomant单独及与奥曲肽联合使用对接受恒定pegvisomant治疗的肢端肥大症患者的内源性GH水平的影响：一项长达6小时的试验研究
J Roemmler,B Steffin,B Gutt et al.
J Roemmler et al.
Objective: Co-treatment with somatostatin analogues and growth hormone receptor antagonists in acromegaly might be a new treatment option abolishing the negative effects of monotherapy. Nevertheless, little is known about...
W C Hymer,J Welsch,E Buchmann et al.
W C Hymer et al.
In rat pituitary somatotrophs, cytochrome oxidase is co-packaged with growth hormone (GH) in some storage granules. Because this enzyme is thought to be the molecular photoacceptor of red-near infrared light, and because exposure of diverse...