Richard I G Holt,Ioulietta Erotokritou-Mulligan,Peter H Sönksen
Richard I G Holt
The earliest records of doping in sport come from the Ancient Olympics games when athletes are reported to have taken figs to improve their performance. With the advent of modern pharmacology in the 19th century, many athletes began to expe...
Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats [0.03%]
生长激素缺乏大鼠中表皮生长因子诱导的隐窝畸形和结肠癌变的敏感性降低
Robert E Carroll,Robert A Goodlad,Aleksandra J Poole et al.
Robert E Carroll et al.
Objectives: To evaluate the role of GH in colon carcinogenesis, we examined the formation of aberrant crypt foci (ACFs) and tumor development in wild type (WT) and GH-deficient, spontaneous dwarf rats (SDRs) exposed to th...
Plasma insulin-like growth factor I as predictor of progression and all cause mortality in chronic heart failure [0.03%]
慢性心力衰竭患者血浆胰岛素样生长因子-I预测预后的作用
Mikkel Andreassen,Caroline Kistorp,Ilan Raymond et al.
Mikkel Andreassen et al.
Objectives: Insulin-like growth factor I (IGF-I) is an anabolic growth factor that seems to increase cardiac contractility. Reduced levels of IGF-I may be implicated in progression of CHF. The objective was to compare pla...
Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth [0.03%]
异亮氨酸型等热高蛋白饮食及分支链氨基酸补充饮食可减轻母体营养不良对胎鼠生长的不利影响
Haruta Mogami,Shigeo Yura,Hiroaki Itoh et al.
Haruta Mogami et al.
Maternal undernutrition causes fetal growth restriction. Protein is a vital dietary nutrient for fetal growth, and branched-chain amino acids (BCAA) are noted to have anabolic actions. In this study, we investigated the effects of maternal ...
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects [0.03%]
长效GHRH类似物CJC-1295激活GH/IGF-1轴可改变正常成年人的血清蛋白谱分布
Lucila Sackmann-Sala,Juan Ding,Lawrence A Frohman et al.
Lucila Sackmann-Sala et al.
Objective: To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum. Background: Th...
The First International Standard For Insulin-like Growth Factor-1 (IGF-1) for immunoassay: preparation and calibration in an international collaborative study [0.03%]
国际协作研究制备和校准用于免疫测定的胰岛素样生长因子-1（IGF-1）的第一个国际标准研究报告
C Burns,P Rigsby,M Moore et al.
C Burns et al.
The World Health Organization (WHO) Expert Committee on Biological Standardization (ECBS) has recognized the need for an International Standard for Insulin-like Growth Factor-1 (IGF-1) for the calibration of immunoassays and for the monitor...
Population pharmacokinetic model for human growth hormone in adult patients in chronic dialysis compared with healthy subjects [0.03%]
慢性血透患者和健康受试者人重组生长激素的群体药代动力学模型比较研究
Thomas Klitgaard,Jakob N Nielsen,Mia P Skettrup et al.
Thomas Klitgaard et al.
Objective: To develop a population pharmacokinetic (PK) model of recombinant human growth hormone (rhGH) treatment in patients with end-stage renal disease (ESRD) and healthy volunteers (HVs), to support future study desi...
Ashley S Izzard,Michael Emerson,Sukhpal Prehar et al.
Ashley S Izzard et al.
Background: Although, it is accepted that there is an excess of cardiovascular mortality in acromegaly, it is uncertain whether this is due to the direct effects of growth hormone-induced-cardiomyopathy or is a consequenc...
Experimental arthritis: effect on growth parameters and total skeletal calcium [0.03%]
实验性关节炎对生长指标和全身钙的影响
E del Pozo,J Zapf,A R Mackenzie et al.
E del Pozo et al.
Aim of the study was to investigate the possible mechanisms leading to stunted growth and osteoporosis in experimental arthritis. Fourty-two female rats of 7-8 weeks of age were randomly assigned to three groups of 14 animals each: (a) cont...
Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats [0.03%]
生长激素和生长激素促分泌剂对类固醇处理的大鼠氮平衡及尿素合成的影响
Niels Kristian Aagaard,Thorbjørn Grøfte,Jacob Greisen et al.
Niels Kristian Aagaard et al.
Objectives: Growth hormone (GH) reduces the catabolic side effects of steroid treatment via effects on the amino-nitrogen metabolism. Ipamorelin is a synthetic peptide with GH releasing properties. We wished to study the ...