Osquel Barroso,Patrick Schamasch,Olivier Rabin
Osquel Barroso
Due to its considered performance enhancing effects, human growth hormone (hGH) is abused as a doping agent in sport. Its misuse also carries potentially serious side effects to a person's health. Consequently, hGH and its releasing factors...
Demographic factors influencing the GH system: Implications for the detection of GH doping in sport [0.03%]
影响GH系统的 demographic因素：对运动中检测GH兴奋剂的影响
Anne E Nelson,Ken K Y Ho
Anne E Nelson
Application of methods for detecting GH doping depend on being able to discriminate between abnormal levels due to doping and normal physiological levels of circulating proteins that change in response to exogenous administration. Constitue...
Christer Ehrnborg,Thord Rosén
Christer Ehrnborg
Drugs and methods to improve physical performance among athletes have been used since the beginning of sport history, but the use of performance enhancing drugs has not always been regarded as cheating. In short, the motives for doping are ...
Peter Sönksen
Peter Sönksen
The IOC recognised growth hormone (GH) as a drug of abuse in 1992 and recruited me as an expert to advise them on the development of a test to detect its abuse. After a long gestation period where the IOC gradually changed their attitude to...
R Gutiérrez-Gallego,J Bosch,G Such-Sanmartín et al.
R Gutiérrez-Gallego et al.
Human growth hormone (GH) represents an extremely challenging task from an anti-doping viewpoint. GH is an endogenously produced substance, present at very low levels in circulation (for the most abundant 22kDa isoform approximately 50pM in...
Diet, body composition, and physical fitness influences on IGF-I bioactivity in women [0.03%]
饮食、体成分和身体素质对女性IGF-I活性的影响
J Philip Karl,Joseph A Alemany,Chad Koenig et al.
J Philip Karl et al.
Objective: Insulin-like growth factor I (IGF-I) is a metabolic-regulatory hormone that mediates a variety of physiologic functions. Body composition, fitness status and intake of certain micro- and macronutrients are asso...
Detection of growth hormone responsive proteins using SELDI-TOF mass spectrometry [0.03%]
应用表面增强激光解吸电离飞行时间质谱技术检测生长激素反应蛋白
L Chung,R C Baxter
L Chung
The detection of growth hormone (GH) doping is a significant problem in elite sports. GH is secreted in a pulsatile pattern from the anterior pituitary, influenced by a variety of normal and pathophysiological conditions. Exogenous recombin...
IGF-I abuse in sport: current knowledge and future prospects for detection [0.03%]
运动中滥用胰岛素样生长因子IGF-Ⅰ的现状及未来检测展望
Nishan Guha,Peter H Sönksen,Richard I G Holt
Nishan Guha
As the tests for detecting growth hormone (GH) abuse develop further, it is likely that athletes will turn to doping with insulin-like growth factor-I (IGF-I). IGF-I mediates many of the anabolic actions of growth hormone. It stimulates mus...
Growth hormone isoforms [0.03%]
生长激素异构体
Gerhard P Baumann
Gerhard P Baumann
Human growth hormone (GH) is a heterogeneous protein hormone consisting of several isoforms. The sources of this heterogeneity reside at the level of the genome, mRNA splicing, post-translational modification and metabolism. The GH gene clu...
Moving one step closer to catching the GH cheats: The GH-2004 experience [0.03%]
向抓捕GH作弊者迈进一步：来自GH-2004的体验
Richard I G Holt,E Eryl Bassett,Ioulietta Erotokritou-Mulligan et al.
Richard I G Holt et al.
Growth hormone is abused by athletes for its anabolic and lipolytic properties. The detection of GH abuse is challenging because it is an endogenous hormone whose concentration varies widely in any one day. The GH-2000 project proposed a te...