Picropodophyllotoxin alters EMT in neuroblastoma via inhibition of surface receptors IFG1R and ALK [0.03%]
皮果酸巴豆毒素通过抑制表面受体IGF1R和ALK改变神经母细胞瘤中的上皮间质转化过程
Poonam Bhagriya,Afridi Shaikh,Hetal Roy
Poonam Bhagriya
Neuroblastoma (NB) is a type of paediatric cancer that originates from embryonic sympathoadrenal cells. Despite its paediatric origin, NB is mostly treated with strategy of non-small cell lung cancer like adults due to lack of specific ther...
Cheryl A Conover
Cheryl A Conover
Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and ...
Identification and differentiation of somapacitan, a long-acting growth hormone derivative, and recombinant human growth hormone in equine plasma by LC-HRMS for doping control purpose [0.03%]
一种长效生长激素衍生物somapacitan和重组人生长激素的 horse 血浆识别与区分的新方法：用于反兴奋剂目的的LC-HRMS法
Yoshibumi Shimizu,Michiko Sugai-Bannai,Kazunobu Saito et al.
Yoshibumi Shimizu et al.
Somapacitan, a long-acting growth hormone derivative, and recombinant human growth hormone (rhGH) are protein-based drugs generally used to treat growth disorders and GH deficiency in humans. Due to their potential to enhance the horse perf...
Association of rs35767 polymorphism in the IGF1 gene with athletic performance in power and endurance sports: A meta-analysis [0.03%]
IGF1基因多态性与力量型及耐力型运动员运动成绩的关联：meta分析
João Mendes,João Palma,Amândio Santos et al.
João Mendes et al.
Background: Sport performance is a multifactorial phenotype dependent on the interaction of multiple genetic and non-genetic factors. More than 200 polymorphisms have been associated with athletic performance. The single ...
Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease [0.03%]
孕期相关血浆蛋白A(PAPP-A)与心血管疾病的关系
Cheryl A Conover
Cheryl A Conover
There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular dise...
The association between change in temporal muscle mass and treatment of acromegaly [0.03%]
关于蝶状体肌质量变化与肢端肥大症治疗之间的关系
Serdar Sahin,Ahmet Oz,Burcu Saglamer et al.
Serdar Sahin et al.
Purpose: We aimed to evaluate the relationship between temporal muscle thickness and GH/IGF-1 elevation and the effect of acromegaly treatment on temporal muscle thickness. ...
Medical treatment of acromegaly - When the tumor size matters: A narrative review [0.03%]
肢端肥大症的医学治疗-肿瘤大小很重要：综述性文章
Mirjana Doknic,Marko Stojanovic,Dragana Miljic et al.
Mirjana Doknic et al.
Medical treatment of acromegaly is generally positioned as a second line of treatment after pituitary adenoma surgery. With the rising availability and variety of medications for acromegaly increases our understanding of their effectiveness...
Adult patients with Laron syndrome tend to develop the metabolic syndrome [0.03%]
拉龙综合征成人患者往往会出现代谢综合征
Zvi Laron,Rivka Kauli,Avivah Silbergeld
Zvi Laron
Background: The metabolic Syndrome is the name of a cluster of abnormal clinical and metabolic states, which constitute a risk factor for diabetes and cardiovascular disease. ...
Using site-directed mutagenesis to further the understanding of insulin receptor-insulin like growth factor-1 receptor heterodimer structure [0.03%]
利用位点突变进一步了解胰岛素受体-类胰岛素生长因子-1受体异二聚体结构
Samuel Turvey,Stephen P Muench,Tarik Issad et al.
Samuel Turvey et al.
Type 2 diabetes is characterised by the disruption of insulin and insulin-like growth factor (IGF) signalling. The key hubs of these signalling cascades - the Insulin receptor (IR) and Insulin-like growth factor 1 receptor (IGF1R) - are kno...
Association of circulating leptin, growth hormone, and ghrelin with fibromyalgia: A meta-analysis [0.03%]
循环中瘦素、生长激素和ghrelin与纤维肌痛关联的meta分析
Young Ho Lee,Gwan Gyu Song
Young Ho Lee
Objective: The aim of this study was to evaluate the relationship between levels of leptin, growth hormone (GH), and ghrelin in the bloodstream and fibromyalgia. ...