João Roque,Pedro Marques
João Roque
Objective: Acromegaly is a disorder caused by hypersecretion of growth hormone (GH), resulting in excessive levels of insulin-like growth factor 1 (IGF-1), and almost always due to a pituitary tumor. It is classically ass...
Effect of metformin on thyroid cancer risk in patients with acromegaly: A preliminary observational study [0.03%]
二甲双胍对肢端肥大症患者甲状腺癌风险的影响：一项初步观察研究
Cem Sulu,Ayyuce Begum Bektas,Suleyman Sami Guzel et al.
Cem Sulu et al.
Purpose: To evaluate the role of metformin on thyroid cancer risk in patients with acromegaly. Methods: Medical charts of 534 patients ...
Effect of long-acting growth hormone treatment on endogenous growth hormone secretion in prepubertal patients with idiopathic short stature: A preliminary study [0.03%]
长效生长激素治疗对青春期前特发性矮身材患儿体内源性生长激素分泌的影响：一项初步研究
Han Saem Choi,Ahreum Kwon,Junghwan Suh et al.
Han Saem Choi et al.
Long-acting growth hormone (LAGH) is emerging to be a new preparation for treatment of short stature. We aimed to determine whether 12-month treatment with LAGH in patients with idiopathic short stature has an effect on the nocturnal endoge...
Reduced exercise-induced growth hormone secretion among children with attention-deficit hyperactivity disorder [0.03%]
注意缺陷多动障碍儿童运动诱发生长激素分泌减少
Dan Nemet,Sigal Ben-Zaken,Roi A Eliakim et al.
Dan Nemet et al.
Purpose: Attention-deficit/hyperactivity disorder (ADHD) is typically a chronic, often lifelong condition. Data suggest that ADHD itself and its treatment may be associated with dysregulated growth, including height and B...
Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [0.03%]
非酒精性脂肪肝和非酒精性脂肪性肝炎患者肝脏组织中胰岛素样生长因子Ⅰ受体及生长激素受体的表达
Stephanie A Osganian,Sonu Subudhi,Ricard Masia et al.
Stephanie A Osganian et al.
Objective: The GH and IGF-1 axis is a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) given its lipolytic, anti-inflammatory and anti-fibrotic properties. IGF-1 receptor (IGF-1R) and GH rece...
Avivah Silbergeld,Chen Barazani,Zvi Laron
Avivah Silbergeld
Background: Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received litt...
In missed abortion the decrease of IGF-1 down-regulates PI3K/AKT signaling pathway reducing the secretion of progesterone and β-hCG [0.03%]
胚胎停育时IGF-1下调PI3K/Akt信号通路影响黄体功能的机制研究
Weitao Liang,Tianyuan Zhu,Na Tan et al.
Weitao Liang et al.
Objective: To explore whether the reduction of IGF-1 in missed abortion down-regulates PI3K/AKT signaling pathway, thereby causing trophoblast cell apoptosis and reducing the secretion of β-hCG and progesterone. ...
IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes [0.03%]
IGF-1敲低抑制鸡胚肌管Akt和ERK磷酸化
Takaoki Saneyasu,Tomonori Nakamura,Kazuhisa Honda et al.
Takaoki Saneyasu et al.
Objective: We examined whether auto/paracrine insulin-like growth factor-1 (IGF-1) contributes to the phosphorylation of Akt and ERK in chicken myotubes. ...
Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency [0.03%]
成人孤立性生长激素缺乏症患者牙齿和骨骼的生长状况
Luiz A Oliveira-Neto,Jéssica K F Nascimento,Roberto Salvatori et al.
Luiz A Oliveira-Neto et al.
Objective: To understand the growth of teeth and mandibular and maxillary bones in subjects with isolated growth hormone deficiency (IGHD). Material and m...
Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa [0.03%]
血清IGF-1的时间进程及反应类型及其与住院厌食症患者BMI和瘦素的关系
Christiane Hellwig-Walter,Maik Brune,Dieter Schellberg et al.
Christiane Hellwig-Walter et al.
Objective: Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is...