Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers [0.03%]
仿生递送系统克服消化道肿瘤药物耐药性研究进展
Gou Wu,Ai-Xue Li,Yong-Wei Gu et al.
Gou Wu et al.
Gastrointestinal (GI) cancers remain a major cause of cancer-related mortality worldwide, and multidrug resistance (MDR) is a critical barrier to durable therapeutic response. In GI malignancies, MDR arises from multilayered and interdepend...
Immunotherapy in cancer: Mechanisms and strategies to overcome resistance [0.03%]
癌症免疫疗法：机制及克服耐药性的策略
Haigan Yang,Zhehan Yang,Xianzhe Wang et al.
Haigan Yang et al.
Recent advances in the field of oncology have increased our understanding of the immune system, its response to malignancies and the immune component of the tumor microenvironment (TME). Indeed, information obtained about tumor biology has ...
Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance [0.03%]
靶向非小细胞肺癌的新型代谢弱点克服化疗耐药性
Simona Fontana,Dimas Carolina Belisario,Claudia Giannotta et al.
Simona Fontana et al.
Aims: Non-small cell lung cancer (NSCLC) patients treated with platinum drugs develop chemoresistance. C/EBPβ has alternative translational LAP and LIP isoforms which impact cancer chemoresistance by modulating ABC efflu...
ITPKB suppresses ER calcium release to promote CXCL9 expression and enhance immunotherapy sensitivity in triple-negative breast cancer [0.03%]
ITPKB通过抑制内质网钙释放促进CXCL9表达并增强三阴性乳腺癌免疫治疗敏感性
Kejing Zhang,Xia Wang,Qiaoli Yi et al.
Kejing Zhang et al.
Immunotherapeutic strategies for triple-negative breast cancer (TNBC) have yielded only modest response rates, severely limiting patients' clinical outcomes. Clarifying the underlying mechanisms to reverse immunotherapy resistance therefore...
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer [0.03%]
MZF1介导的GAPDH过表达驱动糖酵解重编程并促进前列腺癌向神经内分泌表型进展
Wang Liu,Lily He,Cuncong Zhong et al.
Wang Liu et al.
Drug resistance to the androgen receptor (AR) antagonist is a critical obstacle in the clinic for advanced prostate cancers. Especially, AR antagonist treatment-induced neuroendocrine progression represents a lethal and therapy-resistant su...
A multifunctional antimicrobial peptide with cell-penetrating and β-lactam-potentiating activities for combating methicillin-resistant Staphylococcus aureus and carbapenem-resistant Enterobacteriaceae infections [0.03%]
一种多功能抗菌肽，可穿透细胞并增强β-内酰胺活性，用于对抗耐甲氧西林金黄色葡萄球菌和碳青霉烯耐药肠杆菌科细菌感染
Xiaoxiao Zhang,Yuxin Zhang,Xiaoxue Zhang et al.
Xiaoxiao Zhang et al.
Aims: The global health crisis posed by New Delhi metallo-β-lactamase-producing carbapenem-resistant Enterobacteriaceae (NDM-CRE) and methicillin-resistant Staphylococcus aureus (MRSA) underscores the urgent need for nov...
ZDHHC16-induced GPX2 S-palmitoylation promotes lenvatinib resistance and inhibits lenvatinib-induced immunogenic cell death in hepatocellular carcinoma [0.03%]
ZDHHC16诱导的GPX2 S-棕榈酰化促进肝癌仑伐替尼耐药并抑制仑伐替尼诱导的免疫原性细胞死亡
Long He,Guangquan Zhang,Yuxiu Sun et al.
Long He et al.
S-palmitoylation is a common and reversible post-translational modification. This study aims to elucidate the functional role and mechanism of S-palmitoylation in lenvatinib resistance and lenvatinib-induced immunogenic cell death (ICD) in ...
Resistance to CAR-based cell therapy: Mechanisms and overcoming strategies [0.03%]
基于CAR的细胞治疗抵抗机制及应对策略研究
Sha Sha,Xiaoyan Pang,Ning Wang et al.
Sha Sha et al.
Chimeric antigen receptor (CAR)-based cell therapy holds great promise for the treatment of both hematological malignancies and solid tumors. However, primary and acquired resistance to CAR-based cell therapy remains a key obstacle to achie...
Protein SUMOylation confers sorafenib resistance in human hepatocellular carcinoma via the induction of PKM2-mediated glycolysis [0.03%]
蛋白质SUMO化通过诱导PKM2介导的糖酵解赋予索拉非尼抗性的人肝癌细胞
Hongchao Yuan,Yuanjun Lu,Zhuofeng Jiang et al.
Hongchao Yuan et al.
Sorafenib resistance remains a major challenge in the treatment of hepatocellular carcinoma (HCC). Through an in vivo CRISPR/Cas9 screen, we identified protein SUMOylation as a key pathway enriched in sorafenib-resistant HCC tumors. SUMO1 e...
Fluorinated multi-mechanism antimicrobial peptides for improved potency against multidrug-resistant bacterial infections [0.03%]
具有多重抗菌机制的氟化抗菌肽可改善对多药耐药细菌感染的作用力
Luyang Gao,Chao Zhong,Qiqi Yu et al.
Luyang Gao et al.
Aims: Antimicrobial peptides (AMPs) are promising alternatives to antibiotics; however, their development is often hampered by poor stability, safety concerns, and uncertain resistance risk. Therefore, this study aimed to...