Pathological calcium influx through amyloid beta pores disrupts synaptic function [0.03%]
病理性的钙离子通过淀粉样蛋白孔道造成突触功能障碍
Temitope Adeoye,Ghanim Ullah
Temitope Adeoye
Alzheimer's disease (AD) is characterized by profound disruption of synaptic function, with mounting evidence suggesting that amyloid-β (Aβ) oligomers disrupt calcium (Ca2+) homeostasis through membrane pore formation. While these pores a...
Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon [0.03%]
神经元对近端结肠肌间卡哈尔细胞的调节功能研究
Salah A Baker,Bernard T Drumm,Manushri Karwa et al.
Salah A Baker et al.
Interstitial cells of Cajal (ICC) generate contractile patterns of colonic motility. We investigated innervation of ICC within the plane of the myenteric plexus (ICC-MY) in proximal colon using mice expressing GCaMP6f in ICC. ICC-MY generat...
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage [0.03%]
MICU1通过抑制线粒体钙超载损伤减轻蛛网膜下腔出血后神经元凋亡
Jie Wang,Yue Cui,Peng-Fei Ding et al.
Jie Wang et al.
Background: Subarachnoid hemorrhage (SAH) is a severe neurological emergency associated with substantial morbidity and mortality. Research into the mechanisms underlying neuronal injury following SAH has identified early ...
CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca2+ signaling consequence [0.03%]
骨骼肌ryanodine受体RYR2突变导致的Ca2+信号异常与心脏疾病的关系研究
Xiao-Hua Zhang,Grace Ellen Donch,Naohiro Yamaguchi et al.
Xiao-Hua Zhang et al.
Precise activation of cardiac ryanodine receptor (RyR2) by small influx of Ca2+ during the action potential triggers the release of SR Ca2+ that activates contraction, a process known as Ca2+-induced Ca2+ release (CICR). Missense mutations ...
Maëliss Toth,Shaymaa Alhabib,Boris Manoury et al.
Maëliss Toth et al.
The calcium ion (Ca2+) is an important second messenger for the organism, participating in the regulation of various physiological responses in all cell types. In view of its crucial role, maintaining calcium homeostasis is important. This ...
Dantrolene normalizes heightened Ca2+ influx in activated T cells from the familial Alzheimer's disease TgF344-AD rats [0.03%]
丹曲林可纠正家族性阿尔茨海默病TgF344-AD大鼠活化T细胞中过高的钙离子流入
Navdeep K Uppal,Anthony Valenzuela,Pamela J Lein et al.
Navdeep K Uppal et al.
Aim: Dysregulation of the peripheral immune response contributes to Alzheimer's disease pathogenesis. Dantrolene, a negative allosteric modulator of ryanodine receptor types 1 and 3, reduces neurodegeneration in Alzheimer...
Silencing CALB1 enhances prostate cancer radiosensitivity via calcium-mediated mitochondrial dysfunction and cellular senescence [0.03%]
沉默CALB1通过钙介导的线粒体功能障碍和细胞衰老增强前列腺癌放射敏感性
Chen Gong,Senmao Li,Ye An et al.
Chen Gong et al.
Background: Prostate cancer remains a leading cause of cancer-related deaths in men, with radioresistance limiting treatment efficacy. This study investigates the role of Calbindin 1 (CALB1), a calcium-binding protein reg...
CNO induced Ca2+ store and glutamate-dependent nonspecific Ca2+ signalling in DREADD-free brain slices [0.03%]
不含DREADD的大脑切片中，CNO诱导的Ca²⁺储罐和谷氨酸依赖性非特异性Ca²⁺信号转导
Xiao-Yu Zhang,Xi Wu,Rui-Yun Bi et al.
Xiao-Yu Zhang et al.
DREADD (design receptors exclusively activated by designer drugs) is a widely used powerful tool designed to study specific cellular functions. However, off-target effects of chemogenetic activators, including clozapine N-oxide (CNO) and de...
NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking [0.03%]
NAADP介导的钙释放通过调节Rab46依赖性的Weibel-Palade小体运输促进血管生成素2分泌
Ryan D Murray,Melissa Rose,Katarina T Miteva et al.
Ryan D Murray et al.
Angiopoietin2 (Ang2), a regulator of angiogenesis, is stored with other pro-inflammatory and pro-thrombotic mediators, in endothelial-specific vesicles called Weibel-Palade bodies (WPBs). Acute stimulation of endothelial cells with histamin...
Regulation of K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, by palmitoylation [0.03%]
棕榈酰化对K＋-依赖性Na＋/Ca2＋交换器亚型4(NCKX4)的调节作用
By Maryam Al-Khannaq,Jonathan Lytton
By Maryam Al-Khannaq
Mammalian K+-dependent Na+/Ca2+ exchangers (NCKX), encoded by the SLC24 gene family, are crucial for maintaining Ca2+ homeostasis. NCKX4, widely expressed in the brain and sensory neurons, plays a key role in neuronal satiety and enamel for...