Daniel Sifrim,Lars Lundell,Frank Zerbib
Daniel Sifrim
Henning Wittenburg
Henning Wittenburg
Gallstones are common in Western countries and due to pain and complications pose a substantial burden on health care systems. In general, cholesterol gallstones are distinguished from bilirubin gallstones. Bilirubin gallstones form if the ...
Jorge Frank,Pamela Poblete-Gutiérrez
Jorge Frank
Porphyria cutanea tarda (PCT) is the most frequent type of porphyria worldwide and results from a catalytic deficiency of uroporphyrinogen decarboxylase (UROD), the fifth enzyme in heme biosynthesis. At least two different types of PCT are ...
Augusto Villanueva,Pippa Newell,Yujin Hoshida
Augusto Villanueva
Inherited liver disorders that cause chronic inflammation, fibrosis, and cirrhosis can lead to the development of liver cancer. Because of the rarity and diversity of some of these syndromes, the relative risk of developing HCC in these pat...
Frank Grünhage,Jacob Nattermann
Frank Grünhage
Treatment response and susceptibility to chronic viral hepatitis C and B may be modified by host genetic factors. The majority of genetic variants that confer a significant risk have been localized in genes involved in immune response. Howe...
Marcin Krawczyk,Leonilde Bonfrate,Piero Portincasa
Marcin Krawczyk
Non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in the Western world, is a clinico-histopathological entity in which excessive triglyceride accumulation in the liver occurs. Non-alcoholic steatohepatitis (NASH) rep...
Alcoholic steatohepatitis [0.03%]
酒精性脂肪性肝炎
Felix Stickel,Helmut K Seitz
Felix Stickel
Severe alcoholic steatohepatitis has a poor prognosis and is characterized by jaundice and signs of liver failure. Its incidence is unknown, but prevalence is around 20% in cohorts of alcoholics undergoing liver biopsy. Diagnosis is establi...
Autoimmune hepatitis [0.03%]
自身免疫性肝炎
Christian P Strassburg
Christian P Strassburg
Autoimmune hepatitis is a chronic inflammatory disease of the liver with a dismal prognosis when left untreated. Key for the improvement of prognosis is a timely diagnosis before cirrhosis has developed. This is reached by the exclusion of ...
Tom H Karlsen,Erik Schrumpf,Kirsten Muri Boberg
Tom H Karlsen
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease leading to fibrotic biliary strictures and liver cirrhosis. The patient population is heterogeneous with regard to disease progression and the presence of co-morbidities, c...
Primary biliary cirrhosis [0.03%]
原发性胆汁性肝硬化
Douglas L Nguyen,Brian D Juran,Konstantinos N Lazaridis
Douglas L Nguyen
Primary biliary cirrhosis (PBC) is an idiopathic chronic autoimmune liver disease that primarily affects women. It is believed that the aetiology for PBC is a combination between environmental triggers in genetically vulnerable persons. The...