Lesley A Houghton
Lesley A Houghton
The symptom of bloating and sometimes associated increase in abdominal girth (distension) is often described by patients as very intrusive, significantly impacting their quality of life. Indeed many patients rank it as their most bothersome...
Satish S C Rao,Kalyani Meduri
Satish S C Rao
Constipation is a common ailment with multiple symptoms and diverse etiology. Understanding the pathophysiology is important to guide optimal management. During the past few years, there have been remarkable developments in the diagnosis of...
The enteric microbiota in the pathogenesis and management of constipation [0.03%]
肠微生物群在便秘发病机制和治疗管理中的作用
E M M Quigley
E M M Quigley
For centuries, fiber has been recommended on an empirical basis for the management of constipation; it has only been in recent decades that the mechanisms whereby fiber and related products may influence colonic function have begun to be el...
S M Scott,M M van den Berg,M A Benninga
S M Scott
The pathophysiological mechanisms underlying chronic constipation in both adults and children remain to be unravelled. This is a not inconsiderable challenge, but is fundamental to improving management of such patients. Rectal sensorimotor ...
Philip G Dinning,Carlo Di Lorenzo
Philip G Dinning
Constipation is a common and distressing condition with major morbidity, health care burden, and impact on quality of life. Colonic motor dysfunction remains the leading hypothesis to explain symptom generation in the most severe cases of c...
Childhood constipation; an overview of genetic studies and associated syndromes [0.03%]
儿童便秘的遗传学研究及综合症概述
B Peeters,M A Benninga,R C Hennekam
B Peeters
Constipation is a common problem in children but little is known about its exact pathophysiology. Environmental, behavioural but also genetic factors are thought to play a role in the aetiology of childhood constipation. We provide an overv...
Natalia Zarate,Nick J Spencer
Natalia Zarate
Chronic constipation is a highly debilitating condition, affecting a significant proportion of the community. The burden to the health care system and impact on individual patients quality of life is immense. Unfortunately, the aetiology un...
Charles H Knowles,Gianrico Farrugia
Charles H Knowles
Some patients with chronic constipation may undergo colectomy yielding tissue appropriate to diagnosis of underlying neuromuscular pathology. The analysis of such tissue has, over the past 40 years, fueled research that has explored the pre...
S Nurko,S M Scott
S Nurko
The coexistence of constipation and fecal incontinence has long been recognised in paediatric and geriatric populations, but is grossly underappreciated in the rest of the adult population. In children, functional fecal incontinence is usua...
Arnold Wald,Luther Sigurdsson
Arnold Wald
This review summarises the literature on quality of life (QOL) assessments in both children and adults with functional constipation. Studies of adults with constipation include subjects from both tertiary care centres and population-based s...