Edouard Louis,Catherine Van Kemseke,Catherine Reenaers
Edouard Louis
Inflammatory bowel diseases (IBD) are classically divided in Crohn's disease (CD) and ulcerative colitis (UC). However, these two entities are still heterogeneous and a further classification in subphenotypes is necessary. Clinical subpheno...
M De Vos,P Hindryckx,D Laukens
M De Vos
The important co-existence of spondylarthritis (SpA) and inflammatory bowel disease (IBD) within the same individual suggests common etiopathogenic mechanisms. This is supported by intriguing similarities between both diseases at the subcli...
C Y Ponsioen
C Y Ponsioen
Primary sclerosing cholangitis is often regarded as an autoimmune disorder and occurs frequently in relation to inflammatory bowel disease. The ongoing fibro-obliterative process of the biliary tree ensues in liver failure or cholangiocarci...
Ernst J Kuipers,Guido N J Tytgat
Ernst J Kuipers
Peter Starkel,I A Leclercq
Peter Starkel
Animal models are being used for several decades to study fibrogenesis and to evaluate the anti-fibrotic potential of therapies and strategies. Although immensely valuable for our understanding of pathophysiological processes, they remain m...
Tatiana Kisseleva,David A Brenner
Tatiana Kisseleva
Liver fibrosis is an outcome of many chronic diseases, and often results in cirrhosis, liver failure, and portal hypertension. Liver transplantation is the only treatment available for patients with advanced stage of fibrosis. Therefore, al...
Invasive and non-invasive methods for the assessment of fibrosis and disease progression in chronic liver disease [0.03%]
慢性肝病纤维化及病情进展的有创和无创评估方法
Laurent Castera
Laurent Castera
Chronic liver diseases represent a major public health problem, accounting for significant morbidity and mortality worldwide. Their prognosis and management greatly depend on the amount and progression of liver fibrosis with the risk of dev...
Liver cirrhosis [0.03%]
肝硬化
Massimo Pinzani,Matteo Rosselli,Michele Zuckermann
Massimo Pinzani
Liver cirrhosis is a frequent consequence of the long clinical course of all chronic liver diseases and is characterized by tissue fibrosis and the conversion of normal liver architecture into structurally abnormal nodules. Portal hypertens...
Genetics and epigenetics in the fibrogenic evolution of chronic liver diseases [0.03%]
慢性肝病纤维化发展的遗传和表观遗传因素
Vincent Zimmer,Frank Lammert
Vincent Zimmer
Recent years have seen unprecedented progress in the identification and characterization of genetic information related to chronic liver diseases (CLDs). However, despite the conceptual benefit in early recognition of at-risk populations am...
Anna Alisi,Rita de Vito,Lidia Monti et al.
Anna Alisi et al.
Numerous paediatric liver diseases from different origins may be complicated by development of liver fibrosis and progression to cirrhosis. Although fibrogenesis, which represents a major driving force for the development of liver fibrosis,...