Maria Domenica Cappellini
Maria Domenica Cappellini
Deferasirox is an oral iron chelator, with a long half-life, that can be given once daily, because it provides a 24-hour chelation. Several phase II trials and a pivotal phase III trial have established that, in transfusion-dependent patien...
The deleterious effects of iron overload in patients with myelodysplastic syndromes [0.03%]
铁过载对骨髓增生异常综合征患者的影响
François Dreyfus
François Dreyfus
Many patients with myelodysplastic syndromes (MDS) have severe anaemia. However, regular blood transfusions, which are widely used to maintain quality of life and prevent anaemia-related morbidity and mortality, have a negative impact on su...
Theo de Witte
Theo de Witte
Haemopoietic stem cell transplantation (HSCT) is an important intervention for malignant and non-malignant blood diseases. However, HSCT is also associated with considerable morbidity and mortality, some of which may be related to iron over...
Cardiac iron across different transfusion-dependent diseases [0.03%]
不同输血依赖性疾病患者的心脏铁过载特征及其与左心室功能障碍的关系研究
John C Wood
John C Wood
Iron overload occurs in patients who require regular blood transfusions to correct genetic and acquired anaemias, such as beta-thalassaemia major, sickle cell disease, and myelodysplastic syndromes. Although iron overload causes damage in m...
Maria Domenica Cappellini
Maria Domenica Cappellini
Moya S Cunningham,Roger J S Preston,James S O&#x;Donnell
Moya S Cunningham
Venous thromboembolism (VTE) is a common complication of malignancy, and is associated with significant morbidity and mortality. Anticoagulant therapy, in the form of heparin and warfarin, plays an important role in the prevention of recurr...
Bloodstream infections in haematology: risks and new challenges for prevention [0.03%]
血液学患者的血流感染：风险与预防的新挑战
Leon J Worth,Monica A Slavin
Leon J Worth
Bloodstream infections are an important cause of morbidity and mortality in the haematology population, and may contribute to delayed administration of chemotherapy, increased length of hospitalisation, and increased healthcare expenditure....
Roch Houot,Ronald Levy
Roch Houot
Therapeutic vaccines for lymphomas have been developed to induce active and long-lasting immune responses against lymphoma capable of eradicating the tumor. Most of these vaccines use the tumor B cell idiotype (the unique variable region of...
Mary Ann Knovich,Jonathan A Storey,Lan G Coffman et al.
Mary Ann Knovich et al.
Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron ...
Martin J Shearer
Martin J Shearer
Vitamin K deficiency bleeding (VKDB) is a rare and potentially life-threatening bleeding disorder of early infancy. Vitamin K stores are low at birth; thereafter breast-fed infants are at risk because of low concentrations in human milk. Cl...