Bleeding in the heritable connective tissue disorders: mechanisms, diagnosis and treatment [0.03%]
遗传性结缔组织疾病的出血：机制、诊断和治疗
Fransiska Malfait,Anne De Paepe
Fransiska Malfait
Easy bruising and bleeding are prominent features of some heritable disorders of connective tissue (HDCT), resulting from fragility of capillaries and the perivascular connective tissue rather than clotting or platelet dysfunction. The blee...
Price Blair,Robert Flaumenhaft
Price Blair
alpha-Granules are essential to normal platelet activity. These unusual secretory granules derive their cargo from both regulated secretory and endocytotic pathways in megakaryocytes. Rare, inheritable defects of alpha-granule formation in ...
Disseminated intravascular coagulation in obstetric disorders and its acute haematological management [0.03%]
产科疾病的弥散性血管内凝血及其急性血液学处理措施
Jecko Thachil,Cheng-Hock Toh
Jecko Thachil
As activation of the coagulation pathway is a physiological response to injury, the development of disseminated intravascular coagulation (DIC) is a warning signal to the clinician that the primary pathological disease state is decompensati...
Molecular biology of mantle cell lymphoma: from profiling studies to new therapeutic strategies [0.03%]
mantle细胞淋巴瘤的分子生物学：从谱型研究到新的治疗策略
Antònia Obrador-Hevia,Silvia Fernández de Mattos,Priam Villalonga et al.
Antònia Obrador-Hevia et al.
Mantle cell lymphoma (MCL) is a well-defined lymphoid malignancy characterized by a rapid clinical evolution and poor response to current therapeutic protocols. The hallmark genetic alteration of MCL is the t(11;14)(q13;32) chromosomal tran...
Anfisa Stanevsky,Gal Goldstein,Arnon Nagler
Anfisa Stanevsky
Large body of clinical and scientific data has been generated since the first cord blood transplantation (CBT) was performed in 1989. Superior immune plasticity of CB grafts, that allows for less stringent HLA matching, is especially valuab...
Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders [0.03%]
嗜酸性粒细胞增多症和嗜酸性粒细胞疾病的发病机制、分类和治疗
Peter Valent
Peter Valent
Eosinophilia is a recurrent feature and diagnostic clue in several hematologic malignancies. In stem cell- and myelopoietic neoplasms, eosinophils are derived from the malignant clone, whereas in lymphoid neoplasms and reactive states, eosi...
Sarah B Murthi,Lynn G Stansbury,John R Hess
Sarah B Murthi
Injury is the leading cause of death in young people and a major cause of loss of years of productive life world wide. Acute surgical care can prevent injury from turning into disability or death but requires prompt access to safe blood pro...
Assessment and management of high-risk pregnancies in women with thrombophilia [0.03%]
血栓形成倾向妇女的高危妊娠的评估和处理
Galit Sarig,Guy Vidergor,Benjamin Brenner
Galit Sarig
Pregnancy is an acquired hypercoagulable state which can lead to gestational vascular complications especially in the presence of other prothrombotic risk factors. The use of anticoagulation for prevention of pregnancy complications in wome...
Albert Farrugia
Albert Farrugia
Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of tech...
Anna L Pozo,Edmund M Godfrey,Kristian M Bowles
Anna L Pozo
Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields. This review examines the aetiology of splenomegaly in the developed world, and describes a logical approach to the patient with splenomegaly....