George Garratty
George Garratty
Drug-induced immune hemolytic anemia (DIIHA) is rare; it can be mild or associated with acute severe hemolytic anemia (HA) and death. About 125 drugs have been implicated as the cause. The HA can be caused by drug-independent antibodies tha...
John Altin,Chong Shen,Adrian Liston
John Altin
Immunoglobulin E (IgE) is a key mediator of anti-parasitic and anti-tumour immunity. However it is also a critical component of atopic and autoimmune diseases, and elevated serum IgE levels are a common indicator of immune dysregulation. In...
Unprovoked venous thromboembolism: Short term or indefinite anticoagulation? Balancing long-term risk and benefit [0.03%]
特发性静脉血栓栓塞症的抗凝治疗期限是短期还是长期？权衡长期风险和利益
M Rodger,M Carrier,E Gandara et al.
M Rodger et al.
Whether to continue oral anticoagulant therapy indefinitely after completing 3 to 6 months of oral anticoagulant therapy for "unprovoked" venous thromboembolism (VTE), is one of the most important unanswered questions in VTE management. Thi...
Thrombopoietic agents [0.03%]
促血小板生成药物
Roberto Stasi,Jenny Bosworth,Elizabeth Rhodes et al.
Roberto Stasi et al.
Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation...
Ashkan Emadi,Steven D Gore
Ashkan Emadi
Over the last 17 years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As(2)O(3)) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As(2)O(3) in front-line thera...
Pathophysiology and management of inherited bone marrow failure syndromes [0.03%]
遗传性骨髓衰竭综合征的发病机制及处理措施
Akiko Shimamura,Blanche P Alter
Akiko Shimamura
The inherited marrow failure syndromes are a diverse set of genetic disorders characterized by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly variable and much broader than previously recognized. The med...
Anne C Goodeve
Anne C Goodeve
The common autosomally inherited mucocutaneous bleeding disorder, von Willebrand disease (VWD) results from quantitative or qualitative defects in plasma von Willebrand factor (VWF). Mutation can affect VWF quantity or its functions mediati...
Biologic and clinical significance of molecular profiling in Chronic Lymphocytic Leukemia [0.03%]
慢性淋巴细胞白血病分子分型的生物学和临床意义分析
Tom Butler,J G Gribben
Tom Butler
CLL is extremely heterogeneous in its clinical course, with some patients living decades with no need for treatment whilst others have a rapidly aggressive clinical course. A major focus of research has been to try to identify those biologi...
David Dingli,S Vincent Rajkumar
David Dingli
Advances in the molecular understanding of myeloma have led to the development of novel agents such as immunomodulatory drugs (IMiDs) and proteasome inhibitors (bortezomib). When used alone, these agents have significant activity against my...
Significance of JAK2 and TET2 mutations in myelodysplastic syndromes [0.03%]
JAK2和TET2突变在骨髓增生异常综合征中的意义
Eva Hellström-Lindberg
Eva Hellström-Lindberg
The pathogenesis of myelodysplastic syndromes involves a pattern of genetic, epigenetic, and immune-mediated mechanisms but little is known about what causes the specific disease features and promotes disease progression in the individual p...