Leonard A Valentino,Mohammad Kawji,Michele Grygotis
Leonard A Valentino
Venous access is an essential aspect of hemophilia care. When peripheral venipuncture is not feasible, central venous access devices (CVADs) or the creation of an arteriovenous fistula (AVF) allow the infusion of clotting factor concentrate...
Heather A Leitch
Heather A Leitch
The myelodysplastic syndromes (MDS) are characterized by cytopenias and acute myeloid leukemia risk. Most MDS patients eventually require transfusion of red blood cells for anemia, placing them at risk of iron overload (IOL). In beta-thalas...
Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia [0.03%]
NOTCH1诱导的T细胞急性淋巴细胞白血病的分子病理及靶向治疗
Maddalena Paganin,Adolfo Ferrando
Maddalena Paganin
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting from the malignant transformation of immature T-cell progenitors. Originally associated with a dismal prognosis, the outcome of T-ALL patients has impr...
Marcel Levi,Joost C Meijers
Marcel Levi
In patients with disseminated intravascular coagulation (DIC) a variety of altered coagulation parameters may be detectable, such as thrombocytopenia, prolonged global coagulation times, reduced levels of coagulation inhibitors, or high lev...
Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment [0.03%]
遗传性出血性血管瘤的发病机制、诊断与治疗
Claire L Shovlin
Claire L Shovlin
Hereditary haemorrhagic telangiectasia, inherited as an autosomal dominant trait, affects approximately 1 in 5000 people. The abnormal vascular structures in HHT result from mutations in genes (most commonly endoglin or ACVRL1) whose protei...
Claudio Ponticelli,Khaled M Musallam,Paolo Cianciulli et al.
Claudio Ponticelli et al.
Increased survival in patients with β thalassaemia major (TM) allowed for several morbidities to manifest. Renal manifestations of the disease and its treatment have been poorly evaluated. There is evidence, mainly from studies in the paed...
Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma [0.03%]
复发性经典型霍奇金淋巴瘤患者的新型治疗策略
Adam Jona,Anas Younes
Adam Jona
The treatment of patients with relapsed and refractory Hodgkin lymphoma (HL), especially those who relapse after autologous stem cell transplantation, remains challenging. Patients with HL whose disease relapses after stem cell transplantat...
Ronald G Strauss
Ronald G Strauss
Most infants with birth weight
Emmanouil Papadakis,Ron Hoffman,Benjamin Brenner
Emmanouil Papadakis
Myeloproliferative disorders are commonly associated with thrombohemorrhagic manifestations. The current review highlights recent advances in understanding the epidemiology and pathogenetic mechanisms of thrombotic and bleeding complication...
Paul Monagle,Fiona Newall,Janine Campbell
Paul Monagle
Anticoagulation in children is problematic for many reasons, related to the patient population as well as the anticoagulant drugs themselves. This paper describes the multitude of reasons why providing anticoagulation therapy in children is...