Valery Leytin
Valery Leytin
For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways o...
Requirements for immune recognition and processing of factor VIII by antigen-presenting cells [0.03%]
免疫细胞呈递因子VIII的免疫识别和处理要求
Simon D van Haren,Aleksandra Wroblewska,Kathelijn Fischer et al.
Simon D van Haren et al.
Generation of inhibitory antibodies upon repeated FVIII infusion represents a major complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for orchestration of humoral immune responses. APCs are capable of...
Adverse events and safety issues in blood donation--a comprehensive review [0.03%]
献血者的不良事件和安全问题——全面综述
Karin Amrein,Angelika Valentin,Gerhard Lanzer et al.
Karin Amrein et al.
Although blood donation is generally safe, a variety of risks and complications exist, the most common being iron deficiency, vasovagal reactions and citrate-related events. In the last decades, extensive efforts have significantly improved...
Sameek Roychowdhury,Moshe Talpaz
Sameek Roychowdhury
Chronic myeloid leukemia (CML) is a myeloproliferative disorder that affects 5000 new patients per year in the United States. Prior to 10 years ago, durable remission was rare and patients often underwent bone marrow transplantation with su...
Dieter Hoelzer,Nicola Gökbuget
Dieter Hoelzer
ALL blast cells express a variety of specific antigens e.g. CD19, CD20, CD22, CD33, and CD52, which serve as targets for Monoclonal Antibodies (MoAbs). So far, the most experience is available for anti-CD20 (rituximab), which has been combi...
Optimal management of older patients with chronic lymphocytic leukemia: some facts and principles guiding therapeutic choices [0.03%]
慢性淋巴细胞白血病老年患者的治疗管理：指导治疗选择的一些事实和原则
Tamar Tadmor,Aaron Polliack
Tamar Tadmor
Chronic lymphocytic leukemia (CLL) is a disease of older patients and median age at diagnosis is 72 years. This older group is under-represented in clinical trials, (median age 58-62 years). Here we review background data on incidence, surv...
The role of dietary vitamin K in the management of oral vitamin K antagonists [0.03%]
饮食中维生素K在口服维生素K拮抗剂管理中的作用
Michael V Holmes,Beverley J Hunt,Martin J Shearer
Michael V Holmes
Vitamin K antagonists (VKA) have been the mainstay of oral anticoagulant therapy for over 60years. In this review we critically assess the evidence for the importance of vitamin K nutrition during VKA therapy; the methodologies for measurin...
Sue Pavord,Bethan Myers
Sue Pavord
With the rising prevalence of kidney disease, clinicians are increasingly faced with concerns about potential thrombotic and bleeding complications. Thrombotic risk, both arterial and venous, predominates with all severities of kidney disea...
Shahinaz M Gadalla,Sharon A Savage
Shahinaz M Gadalla
Telomeres are long (TTAGGG)(n) nucleotide repeats and an associated protein complex located at the end of the chromosomes. They shorten with every cell division and, thus are markers for cellular aging, senescence, and replicative capacity....
E Gluckman
E Gluckman
Since the first human cord blood transplant, performed in 1988, cord blood banks have been established worldwide for collection and cryopreservation of cord blood for allogeneic hematopoietic stem cell transplant. Umbilical cord blood (UCB)...