Jieun Uhm,John Kuruvilla
Jieun Uhm
ABVD continues to be the standard of care for patients with advanced stage Hodgkin Lymphoma (HL) although escalated BEACOPP has improved survival in one randomized controlled trial (RCT). More intensive regimens have higher rates of acute a...
What do I need to know about immunoglobulin light chain (AL) amyloidosis? [0.03%]
需要了解的免疫球蛋白轻链(AL)淀粉样变性病症的相关知识有哪些？
Angela Dispenzieri,Morie A Gertz,Francis Buadi
Angela Dispenzieri
Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the...
Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists [0.03%]
维生素K抗凝剂的潜在危害——血管钙化
Martijn L L Chatrou,Kristien Winckers,Tilman M Hackeng et al.
Martijn L L Chatrou et al.
Vitamin K-antagonists (VKA) are the most widely used anti-thrombotic drugs with substantial efficacy in reducing risk of arterial and venous thrombosis. Several lines of evidence indicate, however, that VKA inhibit not only post-translation...
The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia [0.03%]
B细胞前体急性淋巴细胞白血病的染色体和基因组异常的临床意义
Anthony V Moorman
Anthony V Moorman
Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of childhood. The current treatment of paediatric ALL is highly successful with up to 90% children being cured. In contrast, survival rates for adult ALL a...
Hyperleukocytosis, leukostasis and leukapheresis: practice management [0.03%]
高白细胞血症、白细胞淤滞和血细胞分离术：管理方法
Chezi Ganzel,Joanne Becker,Paul D Mintz et al.
Chezi Ganzel et al.
Hyperleukocytosis, arbitrarily defined in acute leukemia as a white blood cell count greater than 100,000/mL, often is associated with increased morbidity and mortality in patients with leukemic processes. It can induce leukostasis, tumor l...
Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia [0.03%]
冷凝集素介导的自身免疫性溶血性贫血的诊断和治疗
Sigbjørn Berentsen,Geir E Tjønnfjord
Sigbjørn Berentsen
Exact diagnosis of the subtype has essential therapeutic consequences in autoimmune hemolytic anemia. Cold-antibody types include primary chronic cold agglutinin disease (CAD) and rare cases of cold agglutinin syndrome (CAS) secondary to ca...
CNS prophylaxis in diffuse large B-cell lymphoma: if, when, how and for whom? [0.03%]
弥漫性大B细胞淋巴瘤的中枢神经系统预防：对谁？何时？怎样？如何改进？
Tali Siegal,Neta Goldschmidt
Tali Siegal
Central nervous system (CNS) relapse is an uncommon devastating complication of diffuse large B-cell lymphoma (DLBCL) that usually occurs within 2 years from initial diagnosis. Its pathophysiology is poorly understood and there is no consen...
Ex-vivo expansion of red blood cells: how real for transfusion in humans? [0.03%]
体外红细胞扩增：人类输血的可行性如何？
Anna Rita Migliaccio,Elena Masselli,Lilian Varricchio et al.
Anna Rita Migliaccio et al.
Blood transfusion is indispensable for modern medicine. In developed countries, the blood supply is adequate and safe but blood for alloimmunized patients is often unavailable. Concerns are increasing that donations may become inadequate in...
Jordan Schecter,Naomi Galili,Azra Raza
Jordan Schecter
Advances in therapy can essentially be measured using two parameters; introduction of a new agent which benefits an increased number of patients over prevailing treatments or more selective use of an existing drug by matching it to the biol...
Sarah L Davis,T J Littlewood
Sarah L Davis
Secondary anaemia or the anaemia of chronic disease (ACD) is the commonest form of anaemia in hospitalised patients and the second most prevalent anaemia worldwide after iron deficiency. It is characterised by defective iron incorporation i...