Volker H Haase
Volker H Haase
A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased eryt...
Etty Grad,Haim D Danenberg
Etty Grad
The complex relationship between the inflammatory response and vascular injury and repair is of major importance to the pathogenesis of cardiovascular disease. CRP is not only a strong marker for cardiovascular morbidity but a modulator tha...
Mutational landscape of AML with normal cytogenetics: biological and clinical implications [0.03%]
染色体核型正常的AML的突变图谱及其生物学和临床意义
Maria Paola Martelli,Paolo Sportoletti,Enrico Tiacci et al.
Maria Paola Martelli et al.
Acute myeloid leukemia (AML) is a molecularly heterogeneous disease. Based on cytogenetics and FISH, AML patients are stratified into three major risk categories: favourable, intermediate and unfavourable. However, prognostic stratification...
Yuana Yuana,Auguste Sturk,Rienk Nieuwland
Yuana Yuana
Body fluids contain surprising numbers of cell-derived vesicles which are now thought to contribute to both physiology and pathology. Tools to improve the detection of vesicles are being developed and clinical applications using vesicles fo...
Donor lymphocyte infusions for relapse after allogeneic transplantation: when, if and for whom? [0.03%]
同种异体移植后复发的供者淋巴细胞输注：何时、何因和适用于谁？
Ying-Jun Chang,Xiao-Jun Huang
Ying-Jun Chang
Donor lymphocyte infusion (DLI) using unstimulated leukapheresis is one of the most effective treatment strategies for patients with hematological malignancies; its graft-versus-leukemia effects make it especially effective in chronic myelo...
Genetics of graft-versus-host disease: the major histocompatibility complex [0.03%]
移植物抗宿主病的遗传学：主要组织相容性复合体
Effie W Petersdorf
Effie W Petersdorf
Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human...
Ibraheem H Motabi,John F DiPersio
Ibraheem H Motabi
The use of mobilized peripheral blood stem cells (PBSCs) has largely replaced the use of bone marrow as a source of stem cells for both allogeneic and autologous stem cell transplantation. G-CSF with or without chemotherapy is the most comm...
Matthew A Lunning,Julie M Vose
Matthew A Lunning
Indolent lymphoma comprises a unique and challenging subset of non-Hodgkin lymphoma (NHL). While definitions of indolence will vary, the most common indolent NHL subtypes include follicular lymphoma, marginal zone lymphoma, and small lympho...
Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction [0.03%]
中性粒细胞胞外陷阱（NETs）与感染相关的血管功能障碍
Elizabeth E Gardiner,Robert K Andrews
Elizabeth E Gardiner
The innate immune system orchestrated by leukocytes primarily neutrophils, serves to remove dead and dying host cells and to provide protection against invasion by pathogens. Failure of this system results in the onset of sepsis leading to ...
K P M van Galen,E P Mauser-Bunschoten,F W G Leebeek
K P M van Galen
von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur. Especially in patients with severe VWD, joint bleeds have been described in up to 45% of the ...