Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention [0.03%]
Dickkopf-1是骨髓瘤骨病的关键调节因子：治疗干预的机会与挑战
Fuling Zhou,Shan Meng,Huanjin Song et al.
Fuling Zhou et al.
Myeloma bone disease (MBD) is the most visible aspect of plasma cell myeloma (PCM), which is characterized by the displacement of hematopoiesis and the formation of osteolytic bone lesions. The secreted glycoprotein Dickkopf-1 (DKK1), an in...
Notch signaling in hematopoietic cell transplantation and T cell alloimmunity [0.03%]
诺特定理在造血细胞移植和T细胞异免疫中的作用
Christen L Ebens,Ivan Maillard
Christen L Ebens
Notch signaling can regulate both hematopoietic progenitors and alloimmune T cells in the setting of allogeneic bone marrow or hematopoietic cell transplantation (allo-HCT). Ex vivo culture of multipotent blood progenitors with immobilized ...
Amer M Zeidan,Yuliya Linhares,Steven D Gore
Amer M Zeidan
After being a neglected and poorly-understood disorder for many years, there has been a recent explosion of data regarding the complex pathogenesis of myelodysplastic syndromes (MDS). On the therapeutic front, the approval of azacitidine, d...
Irit Avivi,Dina Stroopinsky,Tamar Katz
Irit Avivi
Anti-CD20 monoclonal antibodies (MoAbs), employed in treating CD20⁺ lymphomas and autoimmune diseases, appear to have broader functions than just eradicating malignant B-cells and decreasing autoantibody production. Rituximab-induced T-cel...
Vena cava filters for management of venous thromboembolism: a clinical review [0.03%]
下腔静脉滤器在静脉血栓栓塞症中的应用进展及评价：临床评述
Anita Rajasekhar,Michael B Streiff
Anita Rajasekhar
Venous thromboembolism (VTE) is the common cause of morbidity and mortality. Vena cava filters (VCF) represent an important alternative to anticoagulation for management of VTE. VCF use has increased dramatically with the availability of re...
Immunotherapeutic strategies for relapse control in acute myeloid leukemia [0.03%]
急性髓性白血病复发控制的免疫治疗策略
Anna Martner,Fredrik Bergh Thorén,Johan Aurelius et al.
Anna Martner et al.
Despite that the initial phases of chemotherapy induce disappearance of leukemic cells in many patients with acute myeloid leukemia (AML), the prevention of life-threatening relapses in the post-remission phase remains a significant clinica...
Developments in the immunophenotypic analysis of haematological malignancies [0.03%]
血液系统恶性肿瘤免疫表型分析研究进展
Kathy Heel,Tania Tabone,Kimberley J Röhrig et al.
Kathy Heel et al.
Immunophenotyping is the method by which antibodies are used to detect cellular antigens in clinical samples. Although the major role is in the diagnosis and classification of haematological malignancies, applications have expanded over the...
Massimo Franchini,Pier Mannuccio Mannucci
Massimo Franchini
Hemophilia A is an X-linked hereditary bleeding disorder due to the deficiency of coagulation factor VIII (FVIII). According to the degree of FVIII deficiency, mild, moderate or severe forms are recognized. Although patients with mild hemop...
P L den Exter,T van der Hulle,M Lankeit et al.
P L den Exter et al.
The long-term clinical course of acute pulmonary embolism (PE) is complicated by high rates of serious adverse events, both before and after cessation of anticoagulant therapy. These adverse events include recurrent venous thromboembolism, ...
Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders [0.03%]
遗传性球形红细胞增多症、椭圆形红细胞增多症及其他红细胞膜疾病
Lydie Da Costa,Julie Galimand,Odile Fenneteau et al.
Lydie Da Costa et al.
Hereditary spherocytosis and elliptocytosis are the two most common inherited red cell membrane disorders resulting from mutations in genes encoding various red cell membrane and skeletal proteins. Red cell membrane, a composite structure c...