Diagnosis and management of complement mediated thrombotic microangiopathies [0.03%]
补体介导的血栓性微血管病的诊断和治疗
Spero R Cataland,Haifeng M Wu
Spero R Cataland
Historically, attempts were made to differentiate acquired thrombotic thrombocytopenic purpura (TTP) from atypical hemolytic uremic syndrome (aHUS) based upon the age at presentation and the presence of neurologic or renal injury. Although ...
The sex difference in haemoglobin levels in adults - mechanisms, causes, and consequences [0.03%]
成人血红蛋白水平的性别差异：机制、原因及影响
William G Murphy
William G Murphy
Men and women have different mean haemoglobin levels in health in venous blood - women have mean levels approximately 12% lower than men. A similar sex-related difference in haemoglobin levels in adult animals is found in many species of ma...
Rusudan K Hopman,John F DiPersio
Rusudan K Hopman
Use of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood hematopoietic progenitor cells (HPCs) has largely replaced bone marrow (BM) as a source of stem cells for both autologous and allogeneic cell transplantation. W...
Bone marrow necrosis and fat embolism syndrome in sickle cell disease: increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection [0.03%]
镰形细胞病的骨髓坏死和脂肪栓塞综合征：非SS基因型患者的易感性增加以及与人细小病毒B19感染可能相关的研究
Dimitris A Tsitsikas,Giorgio Gallinella,Sneha Patel et al.
Dimitris A Tsitsikas et al.
Fat embolism syndrome (FES) due to extensive bone marrow necrosis (BMN) in sickle cell disease (SCD) is a potentially under-diagnosed complication associated with severe morbidity and mortality. We identified 58 cases reported in the world ...
Targeting platelet receptor function in thrombus formation: the risk of bleeding [0.03%]
靶向血小板受体在血栓形成中的作用：出血的风险
Frauke Swieringa,Marijke J E Kuijpers,Johan W M Heemskerk et al.
Frauke Swieringa et al.
In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this ...
Management of venous thromboembolism in cancer patients and the role of the new oral anticoagulants [0.03%]
癌症患者的静脉血栓栓塞症的治疗及新型口服抗凝药物的作用
Caitlin Wharin,Vicky Tagalakis
Caitlin Wharin
Patients with cancer are at high risk for venous thromboembolism (VTE). Most clinical guidelines agree that low-molecular-weight heparins (LMWHs) are the preferred anticoagulants for the prevention and treatment of VTE in cancer patients. H...
Learnings from over 25 years of PNH experience: the era of targeted complement inhibition [0.03%]
PNH超过25年的经验教训：靶向补体抑制的时代
Ellen Heitlinger
Ellen Heitlinger
Paroxysmal nocturnal haemoglobinuria (PNH) is a progressive and life-threatening disease that causes thrombosis, end organ damage and impaired quality of life. Chronic uncontrolled complement activation leads to chronic haemolysis, causing ...
Targeting the ubiquitin proteasome system in haematological malignancies [0.03%]
靶向泛素-蛋白酶体系统治疗血液系统恶性肿瘤
Lisa J Crawford,Alexandra E Irvine
Lisa J Crawford
The ubiquitin proteasome system (UPS) plays a central role in cellular protein homeostasis through the targeted destruction of damaged/misfolded proteins and regulatory proteins that control critical cellular functions. The UPS comprises a ...
Iron and transfusion medicine [0.03%]
铁和输血医学
Sophie Waldvogel-Abramovski,Gérard Waeber,Christoph Gassner et al.
Sophie Waldvogel-Abramovski et al.
Blood bankers have focused their energy to secure blood transfusion, and only recently have studies been published on the effect of blood donation on iron metabolism. In many facilities, hemoglobin measurement is only performed just before ...
Julie Kanter,Rebecca Kruse-Jarres
Julie Kanter
Sickle cell disease (SCD) is a genetic disorder characterised by anaemia and "sickling" of red blood cells, leading to chronic haemolytic anaemia, vascular injury, and organ dysfunction. Although children and adults experience many similar ...