Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis [0.03%]
血管性血友病因子和ADAMTS13在动脉血栓形成中的作用：系统评价和 Meta 分析
Michelle A H Sonneveld,Moniek P M de Maat,Frank W G Leebeek
Michelle A H Sonneveld
Von Willebrand Factor (VWF) plays an important role in hemostasis by mediating platelet adhesion and aggregation. Ultralarge VWF multimers are cleaved by ADAMTS13 in smaller, less procoagulant forms. An association between high VWF levels a...
The past and future of CD33 as therapeutic target in acute myeloid leukemia [0.03%]
急性髓系白血病治疗靶点CD33的研究进展与未来展望
George S Laszlo,Elihu H Estey,Roland B Walter
George S Laszlo
CD33 is a myeloid differentiation antigen with endocytic properties. It is broadly expressed on acute myeloid leukemia (AML) blasts and, possibly, some leukemic stem cells and has therefore been exploited as target for therapeutic antibodie...
Gritta E Janka,Kai Lehmberg
Gritta E Janka
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome and not an independent disease. HLH represents the extreme end of a severe uncontrolled hyperinflammatory reaction that can occur in many underlying c...
Suzanne M Bleker,Michiel Coppens,Saskia Middeldorp
Suzanne M Bleker
The incidence of venous thromboembolism (VTE) is two-fold higher in women than in men during reproductive age, which is likely explained by the use of hormonal contraceptives and by pregnancy in this phase of life. After adjustment for thes...
Paul W A Janssen,Jurriën M ten Berg,Christian M Hackeng
Paul W A Janssen
Antiplatelet drugs are widely used in the treatment of patients with coronary artery disease. Dual anti-platelet therapy with acetylsalicylic acid (ASA) and a P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor) is the recommended strateg...
Cecilia Becattini,Giancarlo Agnelli
Cecilia Becattini
Venous and arterial thromboses have been regarded for many years as two different diseases requiring anticoagulant or antiplatelet treatment, respectively. Platelets have a role in venous thromboembolism through several mechanisms, includin...
Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding [0.03%]
加压素在血液系统疾病治疗及外科手术止血中的应用
Peter J Svensson,Peter B F Bergqvist,Kristian Vinter Juul et al.
Peter J Svensson et al.
Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Wil...
Steven Nathaniel Steinway,Francis LeBlanc,Thomas P Loughran Jr
Steven Nathaniel Steinway
Large granular lymphocyte (LGL) leukemia is a spectrum of rare lymphoproliferative diseases of T lymphocytes and natural killer cells. These diseases frequently present with splenomegaly, neutropenia, and autoimmune diseases like rheumatoid...
Changing treatment paradigms for patients with plasma cell myeloma: impact upon immune determinants of infection [0.03%]
治疗浆细胞瘤患者模式的改变及其对感染免疫因素的影响
Benjamin W Teh,Simon J Harrison,Marc Pellegrini et al.
Benjamin W Teh et al.
Plasma cell myeloma (PCM) is increasing in prevalence in older age groups and infective complications are a leading cause of mortality. Patients with PCM are at increased risk of severe infections, having deficits in many arms of the immune...
Mark J Koury
Mark J Koury
Erythropoiesis, the bone marrow production of erythrocytes by the proliferation and differentiation of hematopoietic cells, replaces the daily loss of 1% of circulating erythrocytes that are senescent. This daily output increases dramatical...