Javier Bolaños-Meade,Robert A Brodsky
Javier Bolaños-Meade
Blood and marrow transplantation is a curative therapy for patients with sickle cell disease yet this option is seldom used. Clinical studies have shown however that children transplanted for this condition can achieve excellent results. In...
Fabian C Verbij,Rob Fijnheer,Jan Voorberg et al.
Fabian C Verbij et al.
The majority of the patients affected by acquired thrombotic thrombocytopenic purpura (TTP) develop autoantibodies directed towards ADAMTS13 that interfere with its von Willebrand Factor (VWF) processing activity. B cell responses have been...
The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates [0.03%]
新型血液成分病原体清除技术的临床和生物学影响
Julie Kaiser-Guignard,Giorgia Canellini,Niels Lion et al.
Julie Kaiser-Guignard et al.
Since 1990, several techniques have been developed to photochemically inactivate pathogens in platelet concentrates, potentially leading to safer transfusion therapy. The three most common methods are amotosalen/UVA (INTERCEPT Blood System)...
The post-PE syndrome: a new concept for chronic complications of pulmonary embolism [0.03%]
肺栓塞的后血栓综合征：慢性并发症的新概念
F A Klok,T van der Hulle,P L den Exter et al.
F A Klok et al.
Long-term follow-up studies have consistently demonstrated that after an episode of acute pulmonary embolism (PE), half of patients report functional limitations and/or decreased quality of life up to many years after the acute event. Incom...
Hairy cell leukemia: Update on molecular profiling and therapeutic advances [0.03%]
毛细胞白血病：分子分型和治疗进展的最新研究动态
Michael R Grever,James S Blachly,Leslie A Andritsos
Michael R Grever
Hairy cell leukemia was initially described as a clinicopathologic entity more than 50 years ago. We have subsequently discovered that HCL is really at least two diseases: classical HCL and the hairy cell leukemia variant. The former is amo...
Irit Avivi,Dan Farbstein,Benjamin Brenner et al.
Irit Avivi et al.
Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) often present with systemic symptoms such as fatigue, shortness of breath and night sweats, mimicking pregnancy-related features which may result in delayed disease diagnosis. Furthermore...
Justin M Watts,Martin S Tallman
Justin M Watts
Acute promyelocytic leukemia (APL) is one of the most exciting stories of modern medicine. Once a disease that was highly lethal, the majority of patients are now cured with the advent of molecularly targeted therapy with all-trans retinoic...
John O Mascarenhas,Nicholas C P Cross,Ruben A Mesa
John O Mascarenhas
The identification of aberrant JAK-STAT signaling in patients with myeloproliferative neoplasms has served as the basis for the development of a new class of targeted agents. Ruxolitinib, the first-in-class oral small molecule JAK1/2 inhibi...
Practical issues surrounding the explosion of tyrosine kinase inhibitors for the management of chronic myeloid leukemia [0.03%]
慢性粒细胞白血病管理中酪氨酸激酶抑制剂的爆炸式增长带来的实际问题探讨
Michael S Mathisen,Hagop M Kantarjian,Jorge Cortes et al.
Michael S Mathisen et al.
The advent of tyrosine kinase inhibitors (TKIs) has drastically changed the treatment outcome of chronic myeloid leukemia (CML). Imatinib was the first TKI approved, and has been considered the standard of care for more than a decade. Secon...
Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine [0.03%]
血小板微颗粒：检测及其在疾病和再生医学中的功能作用评估
Thierry Burnouf,Hadi Alphonse Goubran,Ming-Li Chou et al.
Thierry Burnouf et al.
There is increasing research on and clinical interest in the physiological role played by platelet microparticles (PMPs). PMPs are 0.1-1-μm fragments shed from plasma membranes of platelets that are undergoing activation, stress, or apopto...