Stefan O Ciurea,Ulas D Bayraktar
Stefan O Ciurea
Haploidentical stem cell transplantation (HaploSCT) is an attractive option for patients requiring a hematopoietic stem cell transplant who do not have an HLA-matched donor, because it is cheaper, can be performed faster, and may extend tra...
Daniel W Sherbenou,Christopher R Behrens,Yang Su et al.
Daniel W Sherbenou et al.
With optimal target antigen selection antibody-based therapeutics can be very effective agents for hematologic malignancies, but none have yet been approved for myeloma. Rituximab and brentuximab vedotin are examples of success for the nake...
John C Chapin,Katherine A Hajjar
John C Chapin
Fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly influenced by clot structure, fibrinogen isoforms and polymo...
Sofia E Thorell,Adrian R Parry-Jones,Martin Punter et al.
Sofia E Thorell et al.
Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range fr...
Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside [0.03%]
从实验台到病床：非抗体介导的输血相关性急性肺损伤的发病机制
Anna L Peters,Maike E van Hezel,Nicole P Juffermans et al.
Anna L Peters et al.
Transfusion-related acute lung injury (TRALI) is a major cause of transfusion-related mortality. Causative factors are divided in antibody mediated TRALI and non-antibody mediated TRALI. Antibody mediated TRALI is caused by passive transfus...
De novo thrombotic microangiopathy after non-renal solid organ transplantation [0.03%]
非肾脏实体器官移植后的新型血栓性微血管病
Annelies Verbiest,Jacques Pirenne,Daan Dierickx
Annelies Verbiest
Thrombotic microangiopathy (TMA) is a rare but serious complication of organ transplantation. This article presents the first literature review on TMA following non-renal solid organ transplantation (SOT). Ischemia-reperfusion, immunosuppre...
Drug resistance-related microRNAs in hematological malignancies: translating basic evidence into therapeutic strategies [0.03%]
血液系统恶性肿瘤中与耐药相关的微小核糖核酸：从基础研究到治疗策略的转化
Lingling Xie,Rongrong Jing,Jing Qi et al.
Lingling Xie et al.
Systemic chemotherapy has been used as the first-line therapy for patients with hematological malignancies. Despite the enormous progress in anti-tumor efficacy achieved during the last decades, the development of multidrug resistance (MDR)...
Blocking tumor escape in hematologic malignancies: the anti-PD-1 strategy [0.03%]
阻断血液系统恶性肿瘤的逃逸：抗PD-1策略
Locke J Bryan,Leo I Gordon
Locke J Bryan
Immunotherapy remains an important tool for treatment of hematologic malignancies. The Programmed Death-1 (PD-1) immune checkpoint pathway has emerged as a mechanism of tumor evasion from the anti-tumor immune response. The recent developme...
Bradford R Hirsch,Gary H Lyman
Bradford R Hirsch
As the cost of healthcare continues to rise and patents on biologics near expiration, biosimilars are gaining visibility as a mechanism for cost reduction. Yet, the introduction of biosimilars into the U.S. market will be complex, due to th...
Harnessing the power of alloreactivity without triggering graft-versus-host disease: how non-engrafting alloreactive cellular therapy might change the landscape of acute myeloid leukemia treatment [0.03%]
利用alloreactivity的力量而不引发移植物抗宿主病：非植入性alloreactive细胞疗法如何改变急性髓系白血病治疗的格局
Elizabeth F Krakow,Julie Bergeron,Silvy Lachance et al.
Elizabeth F Krakow et al.
Human leukocyte antigen-mismatched leukocyte infusions outside of the context of transplantation are a promising strategy for acute myeloid leukemia. Recent studies using such non-engrafting alloreactive cellular therapy (NEACT) revealed th...