Xiaoxiao Xu,Meichen Liu,Zhenxing Wang
Xiaoxiao Xu
Diffuse large B-cell lymphoma (DLBCL) remains a therapeutic challenge, as a substantial proportion of patients experience relapsed or refractory (R/R) disease. Antibody-drug conjugates (ADCs) have emerged as a transformative class of target...
An updated systematic review and meta-analysis of Caplacizumab for immune thrombotic thrombocytopenic purpura: Insights into efficacy and safety [0.03%]
关于用于免疫性血栓性血小板减少性紫癜的卡普拉珠单抗疗效和安全性的更新系统评价和meta分析：来自CAPTURE研究的新视角
Mohamed Yassin,Rola Ghasoub,Neda Jafari et al.
Mohamed Yassin et al.
This review synthesizes the current evidence to assess the efficacy and safety of caplacizumab in the treatment of iTTP, focusing on its impact on TPE requirements, time to platelet normalization, relapse prevention, and treatment-related a...
Avatrombopag in immune thrombocytopenia and beyond: Current evidence and emerging perspectives [0.03%]
艾曲波帕在免疫性血小板减少症及其他疾病中的应用：现有证据与未来前景
María Luisa Lozano,Michele P Lambert,Hanny Al-Samkari
María Luisa Lozano
Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by reduced platelet counts, increased bleeding risk, and impaired quality of life. Thrombopoietin receptor agonists are established second-line therapies; among these...
Metabolic alterations in multiple myeloma and extramedullary disease- a novel niche of therapeutic targets [0.03%]
代谢改变在多发性骨髓瘤和髓外疾病中的作用——一种新的治疗靶点生态位
Ellen Purcell,Paul Dowling,Peter O&#x;Gorman et al.
Ellen Purcell et al.
Metabolic reprogramming is a hallmark of cancer, actively contributing to tumour growth and therapeutic resistance. Multiple myeloma (MM) is a common haematological malignancy that exhibits distinct metabolic features, while Extramedullary ...
CAR-T for all? Barriers, facilitators, and interventions to commercial CAR T-cell therapy access [0.03%]
克服障碍，促进CAR-T细胞治疗的临床应用及普及
Sofia Kaparis,Khashayar Eshaghi,Luca Paruzzo et al.
Sofia Kaparis et al.
Chimeric antigen receptor T-cell (CAR-T) immunotherapy has revolutionized the treatment of hematologic malignancies, especially in B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin lymphoma, and multiple myeloma. However, inequitable ...
Darcy Vickers,Arina Martynchyk,Andrea Henden et al.
Darcy Vickers et al.
The gut microbiome (GMB) describes the commensal bacteria which reside in the gastrointestinal tract. Mounting evidence suggests a major role of the GMB in several key aspects of lymphoma development and care. The GMB is implicated in lymph...
Liver dysfunction in AAV-mediated Hemophilia B gene therapy: Mechanisms and management strategies [0.03%]
AAV介导的血友病B基因治疗中的肝功能障碍：机制和管理策略
Xuewen Song,Bingjie Ding,Hongkai Jia et al.
Xuewen Song et al.
Hemophilia B, an X-linked recessive bleeding disorder caused by mutations in the gene encoding coagulation factor IX (FIX). Gene therapy using adeno-associated viral (AAV) vectors targeting hepatocytes has emerged as a promising treatment, ...
Myelofibrosis-associated extramedullary hematopoiesis: Insights into hepatic, pulmonary, and thrombotic complications [0.03%]
骨髓纤维化相关性髓外造血：肝、肺及血栓并发症的新认识
Idoroenyi Amanam,Salman Otoukesh,Vinod Pullarkat et al.
Idoroenyi Amanam et al.
Background: Primary myelofibrosis (PMF), the most aggressive of the Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), is characterized by progressive marrow fibrosis, ineffective hematopoiesis, and a p...
CARing about autoimmune disorders. Use of chimeric antigen receptor engineered T-cells in autoimmune diseases [0.03%]
CAR迎战自身免疫性疾病——嵌合抗原受体修饰的T细胞在自身免疫病中的应用展望
Adrian-Bogdan Tigu,Madalina Nistor,Diana Gulei et al.
Adrian-Bogdan Tigu et al.
Chimeric Antigen Receptor (CAR) T cell therapy, initially developed for hematologic malignancies, has recently emerged as a promising modality for treating autoimmune diseases. This review explores the evolving role of CAR T cells in reprog...
Adenovirus infection in adult allogeneic hematopoietic stem cell transplant recipients: Systematic review and meta-analysis [0.03%]
成人同种异体造血干细胞移植受者腺病毒感染的系统评价和荟萃分析
Nadir Ullah,Marco Muccio,Claudia Bartalucci et al.
Nadir Ullah et al.
Adenovirus (AdV) infection in adult patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) is associated with poor outcomes but management strategies differ among the centers. Data on incidence and risk factors for AdV...