Towards achieving immune reset in autoimmune cytopenias: Insights from clinical experiences with B cell depleting therapies [0.03%]
自身免疫性细胞减少症免疫重建的实现之路——B细胞耗竭疗法的临床启示
David J Kuter,Sigbjørn Berentsen,Nichola Cooper et al.
David J Kuter et al.
Autoimmune cytopenias (AICs) arise from pathogenic autoantibody-mediated destruction of blood cells. Current treatments often fail to achieve durable remission, necessitating long-term treatment including immunosuppression and exposure to t...
Platelet transfusion guidelines for thrombocytopenic patients in non-surgical and non-traumatic care settings: A systematic review and methodological quality assessment [0.03%]
非手术和非创伤科血小板减少症患者输注血小板的指南：系统评价及方法质量评估
Yana Criel,Hendrik B Feys,Emmy De Buck et al.
Yana Criel et al.
This systematic review aimed to identify clinical practice guidelines (CPGs) for platelet transfusion in non-surgical and non-traumatic care settings, and appraise their methodological quality. We searched three databases and eight grey lit...
Guideline-based diagnosis and management of congenital platelet function disorders: Current insights and future directions [0.03%]
基于指南的先天性血小板功能障碍的诊断与管理：现状及展望
Stavroula Parastatidou,Rozeta Sokou,Alexandra Lianou et al.
Stavroula Parastatidou et al.
Congenital platelet function disorders constitute a heterogeneous group of rare, genetic conditions classified according to the affected platelet component or functionality. Sixty entities have been identified, caused by defects in around s...
Phenocopies in acute lymphoblastic leukemia: Redefining leukemia subtypes in the transcriptomic era [0.03%]
急性淋巴细胞白血病中的表型拷贝：转录组时代重新定义白血病亚型
José Vicente Gil,Carolina Fuentes,Miguel Ángel Verde et al.
José Vicente Gil et al.
Phenocopies are leukemias that mirror the transcriptional programs, signaling dependencies and often the clinical behavior of established genetic entities, yet lack their defining lesions. In acute lymphoblastic leukemia (ALL), RNA sequenci...
Wilma Barcellini,Bruno Fattizzo
Wilma Barcellini
Autoimmune hemolytic anemias comprise warm AIHA (wAIHA), due to IgG autoantibodies reacting at body temperatures, and cold agglutinin disease (CAD), due to IgM reacting in cold and strongly activating complement. The diagnosis, based on the...
Ph-chromosome-negative myeloproliferative neoplasms: clonal dynamics are the name of the game [0.03%]
费城染色体阴性髓系肿瘤：克隆动力学是关键
Mohammadamin Noorafrooz,Ramin Noorafrooz,Giovanni Barosi et al.
Mohammadamin Noorafrooz et al.
Ph-chromosome-negative myelo-proliferative neoplasms (MPNs) are characterized by over-production of mature blood cells driven by acquired somatic variants in JAK2, CALR and MPL in most instances. Ph-chromosome-negative MPNs are genetically ...
Underreported and underreviewed: Addressing the gaps in TKI tolerability literature for chronic myeloid leukemia [0.03%]
被低估和忽视的：解决慢性粒细胞白血病TKI耐受性文献中的缺口
Dennis Dong Hwan Kim,Daniela Zackova,Massimo Breccia et al.
Dennis Dong Hwan Kim et al.
Tyrosine kinase inhibitors have transformed survival in chronic-phase chronic myeloid leukemia, yet long-term treatment success increasingly depends on treatment tolerability. Despite its recognized influence on adherence and quality of lif...
Revisiting antiphospholipid syndrome: A thrombo-inflammatory disorder beyond clotting [0.03%]
重新审视抗磷脂综合征：凝血之外的炎性血栓病
Catherine B Ducker,Megan V Preece,Charis Pericleous et al.
Catherine B Ducker et al.
The dysregulation of protective immunothrombosis is termed thrombo-inflammation. Antiphospholipid syndrome (APS) is an antibody mediated autoimmune, inflammatory and prothrombotic disease. APS is an archetypal disease for thrombo-inflammati...
Reinventing the wheel in ischemic stroke: Novel aspects in ADAMTS13 and von Willebrand axis [0.03%]
缺血性脑卒中新发现：ADAMTS13和vWF轴的创新方面
Michail Makris,Paschalis Evangelidis,Nikolaos Devrikis et al.
Michail Makris et al.
A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), is an enzyme that cleaves ultra-large von Willebrand factor (VWF) multimers. ADAMTS13 deficiency leads to thrombotic thrombocytopenic purpura (TTP...
Bystander or perpetrator: Unravelling the significance and challenges of MGUS [0.03%]
旁观者还是肇事者：解开MGUS的意义和挑战
Malini Surapaneni,Jacob Edmisson,Attaya Suvannasankha et al.
Malini Surapaneni et al.
Monoclonal gammopathy of undetermined significance (MGUS) represents a premalignant clinical state with an evolving footprint beyond its established role as a precursor to multiple myeloma. This review is intended for hematologists, oncolog...