Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders [0.03%]
镰状细胞病中的造血干细胞健康状况及其对干细胞治疗和继发性血液系统疾病的影响
Vishaka Gorur,Kamil R Kranc,Miguel Ganuza et al.
Vishaka Gorur et al.
Gene modification of haematopoietic stem cells (HSCs) is a potentially curative approach to sickle cell disease (SCD) and offers hope for patients who are not eligible for allogeneic HSC transplantation. Current approaches require in vitro ...
Optimal management of chemotherapy-induced thrombocytopenia with thrombopoietin receptor agonists [0.03%]
血小板生成素受体激动剂治疗化疗所致血小板减少症的合理用药原则专家共识
Hanny Al-Samkari
Hanny Al-Samkari
Chemotherapy-induced thrombocytopenia (CIT) is a common complication of antineoplastic therapy, resulting in antineoplastic therapy dose reductions, treatment delays, treatment discontinuation, and morbid bleeding events. Despite several de...
Management of transfusion-dependent β-thalassemia (TDT): Expert insights and practical overview from the Middle East [0.03%]
输血依赖性β-地中海贫血(TDT)的管理:来自中东的专家观点和实用综述
Amal El-Beshlawy,Hany Dewedar,Salwa Hindawi et al.
Amal El-Beshlawy et al.
β-Thalassemia is one of the most common monogenetic diseases worldwide, with a particularly high prevalence in the Middle East region. As such, we have developed long-standing experience with disease management and devising solutions to ad...
Access to CAR T-cell therapy: Focus on diversity, equity and inclusion [0.03%]
CAR-T细胞疗法的可及性：关注多样性、公平性和包容性
Maria S Odstrcil,Catherine J Lee,Catherine Sobieski et al.
Maria S Odstrcil et al.
Chimeric antigen receptor T-cell (CAR T-cell) therapy has revolutionized the treatment of hematologic malignancies in patients with relapsed or refractory disease without other treatment options. However, only a very small proportion of pat...
Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management [0.03%]
血小板输注无效导致的HLA同种免疫：机制和处理方法的新观念
Sandhya R Panch,Li Guo,Ralph Vassallo
Sandhya R Panch
Platelet transfusion refractoriness due to HLA alloimmunization presents a significant medical problem, particularly among multiply transfused patients with hematologic malignancies and those undergoing hematopoietic stem cell transplants. ...
Revolutionizing chronic lymphocytic leukemia diagnosis: A deep dive into the diverse applications of machine learning [0.03%]
慢性淋巴细胞白血病诊断革新：机器学习的多样化应用深度探索
Mohamed Elhadary,Amgad Mohamed Elshoeibi,Ahmed Badr et al.
Mohamed Elhadary et al.
Chronic lymphocytic leukemia (CLL) is a B cell neoplasm characterized by the accumulation of aberrant monoclonal B lymphocytes. CLL is the predominant type of leukemia in Western countries, accounting for 25% of cases. Although many patient...
Using artificial intelligence to improve body iron quantification: A scoping review [0.03%]
运用人工智能改善身体铁定量的综述研究
Abdulqadir J Nashwan,Ibraheem M Alkhawaldeh,Nour Shaheen et al.
Abdulqadir J Nashwan et al.
This scoping review explores the potential of artificial intelligence (AI) in enhancing the screening, diagnosis, and monitoring of disorders related to body iron levels. A systematic search was performed to identify studies that utilize ma...
Prophylactic and therapeutic strategies for intraoperative bleeding in women with von Willebrand disease and heavy menstrual bleeding: A systematic review [0.03%]
韦氏症伴月经过多女性患者术中出血的预防和治疗策略：系统综述
H P Eising,M C Punt,J C Leemans et al.
H P Eising et al.
Background: Optimal peri-operative management for women with Von Willebrand disease (VWD) and heavy menstrual bleeding (HMB) remains undetermined. Aim and...
Androgen use in bone marrow failures and myeloid neoplasms: Mechanisms of action and a systematic review of clinical data [0.03%]
雄激素在骨髓失败和骨髓增生性疾病中的作用机制及临床数据系统回顾
Alessandro Bosi,Wilma Barcellini,Francesco Passamonti et al.
Alessandro Bosi et al.
Despite recent advancements, treatment of cytopenia due to bone marrow failures (BMF) and myeloid neoplasms remains challenging. Androgens promote renewal and maturation of blood cells and may be beneficial in these forms. Here we report a ...
Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS) [0.03%]
骨髓增生异常综合征/肿瘤(MDS)的分类、危险度分层和疗效评估：国际MDS研究联盟(icMDS)现状报告
Maximilian Stahl,Jan Philipp Bewersdorf,Zhuoer Xie et al.
Maximilian Stahl et al.
The guidelines for classification, prognostication, and response assessment of myelodysplastic syndromes/neoplasms (MDS) have all recently been updated. In this report on behalf of the International Consortium for MDS (icMDS) we summarize t...