Ven the dose matters: Venetoclax dosing in the frontline treatment of AML [0.03%]
剂量确实重要：在一线治疗急性髓系白血病时应注意维奈克拉的剂量调整
Dahniel Sastow,Hannah Levavi,Nicole Wagner et al.
Dahniel Sastow et al.
Older/unfit adults with AML have worse outcomes and fewer treatment options than their younger/fit counterparts. In vitro studies have found a synergistic effect of hypomethylating agents (HMA) with venetoclax (VEN) on AML cells and since t...
Autologous stem cell transplantation in AL amyloidosis: Muddy waters [0.03%]
自体干细胞移植在AL型淀粉样变性中的应用：浑水摸鱼？
Patrick Hagen,Anita D&#x;Souza
Patrick Hagen
Immunoglobulin light chain (AL) amyloidosis is a malignant plasma cell dyscrasia causing multi-organ morbidity. High dose melphalan and autologous stem cell transplantation (ASCT) is a preferred consolidation approach and is safe with impro...
Measurable residual disease (MRD)-testing in haematological cancers: A giant leap forward or sideways? [0.03%]
血液系统癌症中的可测量残留病灶(MRD)检测：巨大的进步还是偏离了方向？
Qiujin Shen,Xiaowen Gong,Yahui Feng et al.
Qiujin Shen et al.
Measurable residual disease (MRD)-testing is used in many haematological cancers to estimate relapse risk and to direct therapy. Sometimes MRD-test results are used for regulatory approval. However, some people including regulators wrongful...
Absolute and functional iron deficiency: Biomarkers, impact on immune system, and therapy [0.03%]
绝对性和功能性缺铁：生物标志物、对免疫系统的影响和治疗
Marianela Iriarte-Gahete,Laura Tarancon-Diez,Vanesa Garrido-Rodríguez et al.
Marianela Iriarte-Gahete et al.
Iron is essential for numerous physiological processes and its deficiency often leads to anemia. Iron deficiency (ID) is a global problem, primarily affecting reproductive-age women and children, especially in developing countries. Diagnosi...
Longitudinal clinical manifestations of Fanconi anemia: A systematized review [0.03%]
范可尼贫血的临床表现特征：系统综述
Alex Hoover,Lucie M Turcotte,Rachel Phelan et al.
Alex Hoover et al.
Fanconi anemia (FA) is a rare and complex inherited genetic disorder characterized by impaired DNA repair mechanisms leading to genomic instability. Individuals with FA have increased susceptibility to congenital anomalies, progressive bone...
Lacey S Williams,Teja Nagaradona,Prathik Nalamalapu et al.
Lacey S Williams et al.
Acute myeloid leukemia (AML) is a disease primarily affecting older adults. However, not all patients at older ages are suitable for curative treatment with intensive chemotherapy due to "frailty" demonstrated by their functional status, ph...
A B Notarantonio,M Robin,M D&#x;Aveni
A B Notarantonio
Myelodysplastic syndrome (MDS) is a very heterogeneous clonal disorder. Patients with "higher-risk" MDS, defined by specific recurrent genetic abnormalities, have a poor prognosis because of a high risk of progression to secondary acute mye...
Immune thrombocytopenia: Pathophysiology and impacts of Romiplostim treatment [0.03%]
免疫性血小板减少症：发病机制及罗米司亭的治疗效应
John W Semple,Alexandra Schifferli,Nichola Cooper et al.
John W Semple et al.
Immune thrombocytopenia (ITP) is an autoimmune bleeding disease caused by immune-mediated platelet destruction and decreased platelet production. ITP is characterized by an isolated thrombocytopenia (
Christine E Ryan,Anita Kumar
Christine E Ryan
Despite recent therapeutic advancements in the general field of non-Hodgkin lymphoma, effective treatment of relapsed or refractory (R/R) mantle cell lymphoma (MCL) remains a challenge. The development of Bruton tyrosine kinase (BTK) inhibi...
Thrombotic events associated with immune checkpoint inhibitors and novel antithrombotic strategies to mitigate bleeding risk [0.03%]
免疫检查点抑制剂相关的血栓事件及降低出血风险的新型抗凝策略
Jiayi Chen,Shuang Liu,Zheng Ruan et al.
Jiayi Chen et al.
Although immunotherapy is expanding treatment options for cancer patients, the prognosis of advanced cancer remains poor, and these patients must contend with both cancers and cancer-related thrombotic events. In particular, immune checkpoi...