DNA Mismatch Repair-deficient Endometrial Carcinosarcomas Portend Distinct Clinical, Morphologic, and Molecular Features Compared With Traditional Carcinosarcomas [0.03%]
与传统癌肉瘤相比，DNA错配修复缺陷性子宫内膜癌肉瘤具有独特的临床、形态和分子特征
Sheila E Segura,Silvana Pedra Nobre,Yaser R Hussein et al.
Sheila E Segura et al.
Uterine carcinosarcomas (UCSs) are aggressive neoplasms composed of high-grade malignant epithelial and mesenchymal elements with most (∼90%) showing TP53 abnormalities. A subset, however, shows mismatch repair deficiency (MMR-D). We sough...
Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature [0.03%]
携带ALK融合基因的结直肠腺癌：12例临床病理和分子遗传学研究及文献复习
Jerzy Lasota,Małgorzata Chłopek,Bartosz Wasąg et al.
Jerzy Lasota et al.
This study determined the frequency and the clinicopathologic and genetic features of colorectal carcinomas driven by oncogenic fusions of the anaplastic lymphoma kinase gene (ALK). Of the 8150 screened tumors, 12 (0.15%) were immunohistoch...
Thyroid Papillary Microtumor: Validation of the (Updated) Porto Proposal Assessing Sex Hormone Receptor Expression and Mutational BRAF Gene Status [0.03%]
乳头状微小甲状腺肿瘤：验证（更新的）波尔图方案评估性激素受体表达和BRAF基因突变状态
Elvin Aliyev,María J Ladra-González,María Sánchez-Ares et al.
Elvin Aliyev et al.
Given the high incidence and excellent prognosis of many papillary thyroid microcarcinomas, the Porto proposal uses the designation papillary microtumor (PMT) for papillary microcarcinomas (PMCs) without risk factors to minimize overtreatme...
Clinicopathologic Features of Low-grade Appendiceal Mucinous Neoplasm: A Single-institution Experience of 117 Cases [0.03%]
低级别阑尾粘液新生物的临床病理特征：单中心117例报道
Phoenix D Bell,Aaron R Huber,Michael G Drage et al.
Phoenix D Bell et al.
Low-grade appendiceal mucinous neoplasm (LAMN) is an enigmatic tumor that lacks the capacity for classic invasion but can dissect through the appendiceal wall, causing pseudomyxoma peritonei (PMP). Most large studies of the histologic spect...
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology? [0.03%]
2020年WHO分类：软组织肿瘤病理学新在哪里？
Michael E Kallen,Jason L Hornick
Michael E Kallen
The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone was published in early 2020. The revisions reflect a consensus among an international expert editorial board composed of soft tissue and bon...
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma [0.03%]
MDM2扩增的脂肪肉瘤改良预后分层系统提案
Jonathan J Tucci,Nooshin K Dashti,Justin M M Cates
Jonathan J Tucci
Despite the release of anatomic site-specific staging systems for soft tissue sarcomas in the eighth edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, the algorithms for sarcomas arising in the extremities/trun...
Immunohistochemical Characterization of Giant Cell Tumor of Bone Treated With Denosumab: Support for Osteoblastic Differentiation [0.03%]
接受地诺单抗治疗的骨巨细胞瘤的免疫组织化学特征：支持成骨分化
Darcy A Kerr,Iva Brcic,Julio A Diaz-Perez et al.
Darcy A Kerr et al.
Giant cell tumor of bone is a locally aggressive, rarely metastasizing neoplasm. Evidence suggests that the neoplastic cells may be osteoblastic in differentiation. Standard treatment is surgical removal, but medical therapy with denosumab,...
Molecular Characterization of Neuroendocrine Carcinomas of the Endometrium: Representation in All 4 TCGA Groups [0.03%]
子宫神经内分泌癌的分子特征：代表所有4个TCGA组
Brooke E Howitt,Fei Dong,Marina Vivero et al.
Brooke E Howitt et al.
High-grade neuroendocrine carcinomas (NEC) of the endometrium are rare and account for
Primary Pulmonary Myxoid Sarcoma and Myxoid Angiomatoid Fibrous Histiocytoma: A Unifying Continuum With Shared and Distinct Features [0.03%]
原发性肺粘液肉瘤和粘液样血管网状纤维组织细胞增生症：具有共同特征和独特特征的统一体征继续研究
Hongxing Gui,Robyn T Sussman,Bo Jian et al.
Hongxing Gui et al.
Primary pulmonary myxoid sarcoma (PPMS) is a recently reported, exceedingly rare low-grade lung neoplasm characterized by reticular/lace-like growth of spindle to epithelioid cells embedded in an abundant myxoid matrix. Morphologically, it ...
Chronic Intervillositis of Unknown Etiology: Development of a Grading and Scoring System That Is Strongly Associated With Poor Perinatal Outcomes [0.03%]
病因未明的慢性绒毛间隙炎：一种与不良围产期结局相关的分级和评分系统的建立
Fanny Sauvestre,Aurélien Mattuizzi,Loïc Sentilhes et al.
Fanny Sauvestre et al.
Chronic intervillositis of unknown etiology (CIUE) is a rare placental disease characterized by intervillous infiltration of maternal macrophages and associated with poor pregnancy outcomes and a high risk of recurrence in subsequent pregna...