Clinicopathologic and Whole Exome Sequencing Analyzes of High-Grade Serous Carcinoma-Like Carcinoma of the Breast Reveal Unique Genetic Profile and Poor Clinical Outcome [0.03%]
对中国高分级浆液性卵巢癌样乳腺癌的临床病理及外显子组测序分析显示其具有独特的基因改变和较差的预后特征
Wen-Yu Hsiao,Thi Truc Anh Nguyen,Wei Yang et al.
Wen-Yu Hsiao et al.
We identified 9 cases of primary high-grade serous-like carcinoma (HG-SL-Ca) of the breast that displayed the morphology of high-grade serous carcinoma of Müllerian origin. These cases could represent a new entity of breast carcinoma. This...
Comparison of Immunohistochemistry With Fluorescence In Situ Hybridization for Assessment of CCND1 Rearrangement in Plasma Cell Myeloma [0.03%]
免疫组化与荧光原位杂交技术评估浆细胞瘤CCND1重排的比较研究
Maria Y Chen,Anna B Rider,Judith A Ferry et al.
Maria Y Chen et al.
More than half of patients with plasma cell myeloma (PCM) relapse after treatment and require novel therapies. Venetoclax, a highly specific and effective oral BCL2 inhibitor, has a favorable risk-benefit ratio for PCM patients with t(11;14...
Dominant Negative PTEN Alterations in Endometrial Carcinoma Are Associated With Retained Immunohistochemical PTEN Expression [0.03%]
端ometrium癌中主导的负面PTEN改变与保留的免疫组化PTEN表达有关
Kianoosh Keyhanian,Aurelia Busca,Brooke Howitt et al.
Kianoosh Keyhanian et al.
PTEN immunohistochemistry (IHC) is considered complimentary for assessment of PTEN abnormality in endometrial carcinoma (EC), since PTEN IHC staining pattern does not entirely correlate with the presence and absence of mutations on sequenci...
Depth of Liver Invasion as a Novel Predictor for Outcome of Perihilar Cholangiocarcinoma [0.03%]
肝浸润深度可作为预测肝门胆管癌预后的新指标
Tao Zhang,Li Li,Dong-Liang Yang et al.
Tao Zhang et al.
The current American Joint Committee on Cancer (AJCC) pT classification was inaccurate in predicting prognosis for perihilar cholangiocarcinoma (pCCA). This study aimed to propose a novel classification based on the depth of liver invasion ...
A Brief Guide to Interpreting Transbronchial Cryobiopsies for Diffuse Parenchymal Lung Disease [0.03%]
间质性肺病经支气管冷冻活检的病理解读指导意见
Andrew Churg,Joanne L Wright,Peter Manchen et al.
Andrew Churg et al.
Transbronchial cryobiopsies (CB) are increasingly replacing surgical biopsies (video-assisted thoracoscopic/VATS biopsies) for diagnosing diffuse parenchymal lung disease (interstitial lung disease, ILD), but there is very little guidance f...
HPV42: A Common Low-Risk HPV Type Associated With Distinctive Cervicovaginal and Cutaneous Neoplasia [0.03%]
HPV42：一种常见的低危型HPV与独特的宫颈阴道和皮肤肿瘤相关
Karen L Talia,David Hawkes,Gloria Zhang et al.
Karen L Talia et al.
Seborrheic keratosis-like lesion (SKLL) is an extremely rare, morphologically distinct lesion occurring in the cervix and vagina that differs histologically from other squamous intraepithelial lesions in these sites due to its unique morpho...
The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Urachal Neoplasms and Urinary Bladder Glandular Lesions: It's About Time! [0.03%]
关于尿囊肿瘤和膀胱黏膜病变的都柏林国际泌尿病理学会(ISUP)共识会议：是时候该改变了！
Gladell P Paner,Glen Kristiansen,Henning Reis
Gladell P Paner
Prognostic and Predictive Value of SARIFA-status Within Molecular Subgroups of Colorectal Cancer: Insights From the Netherlands Cohort Study [0.03%]
荷兰前瞻性队列研究中SARIFA状态在结直肠癌分子亚型内的预后和预测价值分析
Nic G Reitsam,Kelly Offermans,Colinda C J M Simons et al.
Nic G Reitsam et al.
We recently proposed Stroma AReactive Invasion Front Areas (SARIFA), defined as direct tumor-adipocyte interaction at the invasion front, as a novel hematoxylin-and-eosin (H&E)-based histopathological prognostic biomarker in various cancers...
Adult Granulosa Cell Tumors of the Ovary With Tubular Differentiation: A Report of 80 Examples of an Underemphasized Feature With Clinicopathologic and Genomic Differences From Other Sex Cord-Stromal Tumors [0.03%]
具有管状分化的成年卵巢颗粒细胞肿瘤：80例罕见特征及其与其它性索-间质肿瘤的临床病理和基因组差异报告
Lauren J Ray,Robert H Young,Mark F Sabbagh et al.
Lauren J Ray et al.
Occasional ovarian sex cord-stromal tumors exhibit features suggestive of more than 1 subtype, including some with areas of both "female" (granulosa) and "male" (Sertoli and/or Leydig) cell types. These tumors, historically often referred t...