Renal Tumorigenesis via RAS/RAF/MAPK Pathway Alterations Beyond Papillary Renal Neoplasm With Reverse Polarity [0.03%]
涉及RAS/RAF/MAPK通路改变的乳头状肾逆极性肿瘤之外的肾细胞瘤发生机制研究
Jung Woo Kwon,Peng Wang,Pankhuri Wanjari et al.
Jung Woo Kwon et al.
RAS/RAF/MAPK signaling pathway is one of the best-defined cancer signaling pathways but its role in renal tumorigenesis is unknown outside of papillary renal neoplasm with reverse polarity (PRNRP), which harbors recurrent KRAS alteration. I...
MUC4-positive Fibroblastoma: A Distinctive Hyalinized Spindle Cell Neoplasm With Aberrant Nuclear Beta-catenin Expression and Frequent Biallelic Inactivation of APC [0.03%]
MUC4阳性成纤维细胞瘤：一种具有异常核β-连环蛋白表达和APC基因双等位基因失活的特殊透明变性梭形细胞肿瘤
Federico Repetto,Igor Odintsov,Lynette M Sholl et al.
Federico Repetto et al.
Among soft tissue tumors, MUC4 is expressed in low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma, and is regarded as a specific and sensitive marker for these malignant entities. These tumors are driven by oncogenic fusi...
International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate [0.03%]
国际泌尿病理学会关于癌前病变的共识。工作组一：前列腺
Kenneth A Iczkowski,Angelo M De Marzo,Neeraj Agarwal et al.
Kenneth A Iczkowski et al.
Working Group 1 at ISUP's Cancer Precursors meeting (September 2024) evaluated 5 putative precursors of invasive prostate cancer: high-grade prostatic intraepithelial neoplasia (HGPIN), intraductal carcinoma (IDC), atypical intraductal prol...
Genomic Signatures of Gastric Adenocarcinoma By Tumor Location-Modified Laurén Classification: Highlighting the Molecular Heterogeneity of Mixed-Type Tumors [0.03%]
肿瘤位置修饰的Laurén分类下的胃腺癌基因组特征：突出混合型肿瘤的分子异质性
Harrison M Drebin,Henry Walch,Edaise M Da Silva et al.
Harrison M Drebin et al.
Tumor location-modified Laurén classification (mLC) of gastric adenocarcinoma (GAC) integrates Laurén histologic subtype and tumor location. mLC has been previously proposed and clinically validated as an independent prognostic indicator....
Serous Borderline Tumors of the Testis and Paratestis: A Clinicopathologic Study of 19 Tumors Emphasizing Morphologic Spectrum and Clinical Outcome [0.03%]
睾丸和附睾支持细胞瘤的临床病理研究：着重于形态学范围和临床结果（19例）
Ali Shahabi,Aleksei Konstantinov,Jesse K McKenney et al.
Ali Shahabi et al.
Serous borderline tumors of the testis and paratestis are rare, and experience with these neoplasms is limited. We report a series of 19 tumors, emphasizing their morphologic spectrum and clinical behavior. Eighteen tumors (95%) had convent...
IgM Immunohistochemical Expression is a Potential Risk Factor for Extracutaneous Dissemination in Patients With Primary Cutaneous Follicle Center Lymphoma [0.03%]
IgM免疫组化表达是原发性皮肤滤泡中心淋巴瘤患者发生皮肤外转移的潜在风险因素：一项回顾性研究
Anne M R Schrader,Ruben A L de Groen,Rein Willemze et al.
Anne M R Schrader et al.
Primary cutaneous follicle center lymphoma (PCFCL) is a type of cutaneous B-cell lymphoma with an indolent behavior and a 5-year disease-specific survival of 95%. Given the difficulty of identifying patients at risk for developing extracuta...
Reporting Prostatic Atypical Intraductal Proliferations: Call for a Different Approach [0.03%]
前列腺管内不典型增生的报告：呼吁采取不同的方法
Murali Varma,Glen Kristiansen,Gladell P Paner et al.
Murali Varma et al.
Validation of a New Histopathologic Risk Model in Early Oral Tongue Cancer: A Combination of a Modified Worst Pattern of Invasion and a New Tumor Budding Score [0.03%]
早期间舌癌新型组织病理风险模型的验证：改良型最差侵袭模式与新的肿瘤 budding 评分联合模型
Alhadi Almangush,Tuula Salo,Caj Haglund et al.
Alhadi Almangush et al.
Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. A new histopathologic risk assessment has been recently introduced and we sought to validate its prognostic value in a large multicenter cohort of ear...
Establishing the Diagnosis of Germ Cell Tumors in Patients Presenting With Metastatic Disease: A Series of 55 Cases Emphasizing Challenges Commonly Encountered in Core Biopsies [0.03%]
初诊转移性生殖细胞肿瘤患者的诊断建立：55例回顾强调核心活检中常遇到的挑战
Swati Bhardwaj,Mohammad Salimian,Andres Matoso et al.
Swati Bhardwaj et al.
Germ cell tumors (GCTs) are the most common nonhematopoietic malignancies in young men and typically present as primary testicular masses. However, in ∼12% of cases, GCTs manifest as metastatic disease without a known testicular primary, l...
In Reply to "Reporting Prostatic Atypical Intraductal Proliferations": Call for a Different Approach [0.03%]
关于“报告前列腺导管内非典型增生”的回信：呼吁采取不同的方法
Jane K Nguyen,Reza Alaghehbandan,Christopher J Weight et al.
Jane K Nguyen et al.