Undifferentiated Melanoma: A Clinicopathologic and Gene Expression Analysis Study With Identification of HMGA2 as a Diagnostic Marker [0.03%]
未分化黑色素瘤的临床病理及基因表达分析研究并鉴定HMGA2作为诊断标志物
Grant M Fischer,Diogo Maia-Silva,Dora Dias-Santagata et al.
Grant M Fischer et al.
Undifferentiated melanoma poses a unique diagnostic challenge as, by definition, it lacks expression of the melanocytic markers S100 protein, Sox10, Mart1, and HMB45. Despite this aberrant phenotype, undifferentiated melanoma is characteriz...
DNA Methylation Profiling Separates SDH-Deficient GISTs From KIT-PDGFRA-Driven GISTs and Identifies Predictive Biomarkers for Targeted Therapy [0.03%]
DNA甲基化谱分析将SDH缺陷型GIST与其他由KIT或PDGFRA驱动的GIST分开，并发现针对该病的新疗法生物标记物
Małgorzata Chłopek,Jerzy Lasota,Omkar Singh et al.
Małgorzata Chłopek et al.
Succinate dehydrogenase (SDH), a critical enzyme in the citric acid cycle and respiratory electron transport chain, consists of 4 subunits: SDHA, SDHB, SDHC, and SDHD. Deficiency of a single subunit leads to the loss of SDH activity which i...
Pseudopapillary Osteoblastic Tumor With Psammomatous/Dot-Like Calcification of the Jawbone: A Report of a Hitherto Undescribed Morphologic Variant of Osteoblastoma Supported by Molecular Analysis [0.03%]
具有砂粒样/点状钙化的下颌骨假乳头样成骨性肿瘤：分子分析支持的成骨瘤未曾描述过的形态变体的一例报告
Maiko Tsuchiya,Yoshinao Kikuchi,Daisuke Komura et al.
Maiko Tsuchiya et al.
Osteoblastoma (OB) is a bone-forming tumor typically characterized by FOS rearrangements. When arising in the jawbone, the histologic features overlap with those of cementoblastoma (CB). We report the case of a 20-year-old man with a histol...
The Clinicopathologic Features of Inflammatory Breast Carcinoma (IBC) With Lobular Features [0.03%]
具有小叶特征的炎性乳腺癌（IBC）的临床病理特征
S Emily Bachert,Allison M Onken,Allison S Cleary et al.
S Emily Bachert et al.
Inflammatory breast carcinoma (IBC) is an aggressive form of breast cancer. Prior studies have reported the presence of lobular histology in a small percentage of tumors from patients with IBC. However, the significance of these lobular fea...
Condylomatous Sinonasal Papilloma-A Distinct (Fourth) Subtype That is Commonly Associated With Low-risk Human Papillomavirus [0.03%]
乳头状瘤性鼻窦乳头状瘤与低危型人乳头瘤病毒的关联性较强（第四种亚型）
Ansa Mehreen,Mitra Mehrad,Kim A Ely et al.
Ansa Mehreen et al.
Inverted papilloma (IP) is a benign neoplasm of the nasal cavity and paranasal sinuses, known for its variable risk of recurrence and potential for developing carcinoma. Emerging evidence has shown high rates of activating EGFR mutation, an...
Genomics of T-Cell Lymphomas With CD30/CD15 Co-Expression: Comparison With Anaplastic Large-Cell Lymphoma, ALK-Negative [0.03%]
共表达CD30/CD15的T细胞淋巴瘤基因组学特征与ALK阴性间变性大细胞淋巴瘤对比研究
Joao V Alves de Castro,Jung Kim,Manoj Tyagi et al.
Joao V Alves de Castro et al.
The proper categorization of mature T-cell neoplasms with coexpression of CD30/CD15 is unresolved. Prior studies suggested an overlap with ALK-negative anaplastic large cell lymphoma (ALCL). We evaluated the morphologic, immunophenotypic, a...
Biphasic Myoepithelial Carcinoma With 5p/5q Loss: Morphomolecular Characterization and Provisional Designation of a Proposed Novel Salivary Tumor Entity [0.03%]
具有5p / 5q丢失的双相肌上皮癌：形态分子特征以及新型唾液腺肿瘤实体的临时分类
Philipp Jurmeister,Maximilian Leitheiser,Linda Bergmayr et al.
Philipp Jurmeister et al.
Salivary gland tumors are diagnostically challenging due to major diversity of benign and malignant tumors with enormous intra-tumorous and inter-tumorous heterogeneity and, hence, frequently overlapping histologic features. DNA methylation...
International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder [0.03%]
2024年国际泌尿病理学会共识会议：工作组2-膀胱癌前病变及前驱病变
Michelle R Downes,Antonio Lopez-Beltran,Roberto Contieri et al.
Michelle R Downes et al.
Preneoplastic and precursor lesions are important to recognize and report, as they can influence clinical management decisions. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Florence, Italy, in Se...
Recurrent PDGFRB Mutations in Pulmonary Microcystic Fibromyxoma: A Clinicopathologic and Molecular Analysis of 3 Cases [0.03%]
血小板源性生长因子受体-PDGBRB基因在肺微囊粘液纤维瘤的突变及临床病理分析三例报告
Ming Zhao,Qixing Gong,Xiaoyan Chen et al.
Ming Zhao et al.
Pulmonary microcystic fibromyxoma (PMF), a rare benign mesenchymal neoplasm first described in 2006, remains diagnostically challenging due to histologic overlap with a variety of primary/metastatic myxoid tumors of the lung and absence of ...
Comprehensive Analysis of 15 Cases of ELOC-RCC and Identification of Novel Mutation Site [0.03%]
ELOC-RCC的综合分析及新突变位点鉴定
YuanKai Wu,HuiZhi Zhang,Yang Liu et al.
YuanKai Wu et al.
ELOC-mutated renal cell carcinoma (ELOC-RCC), a newly recognized tumor entity in the fifth edition of the WHO Classification of Tumors of Urinary and Male Genital Organ Tumors (5th WHO Classification), presents morphologic and immunohistoch...