High-Grade Early-Onset Prostate Cancer: Assessment of TMPRSS2::ERG-Negative Tumors Suggests Low Frequency of Germline Alterations and a Pathogenic Role for HOXB13 [0.03%]
TMPRSS2::ERG阴性高分级早期前列腺癌：HOXB13有致病作用及BRCA1/2突变率低的证据
Daisy Maharjan,Stephanie Siegmund,Květoslava Michalova et al.
Daisy Maharjan et al.
Early onset prostate cancer (EOPC; defined herein as prostate cancer [PCa] affecting men ≤ 55 years-old) tends to show low histologic grade, likely representing early detection of indolent tumors that would otherwise be diagnosed later in ...
Protein Kinase C-alpha Gene Fusions in Dendritic Cell Neurofibroma: Distinction From Conventional Neurofibroma [0.03%]
树突细胞神经纤维瘤中的蛋白激酶C-α基因融合：与常规神经纤维瘤的区别区分常规神经纤维瘤中的PKC-α基因融合事件
Arnaud de la Fouchardiere,Elizabeth C Draper,Daniel Pissaloux et al.
Arnaud de la Fouchardiere et al.
Dendritic cell neurofibroma with pseudorosettes is an uncommon but distinctive variant of neurofibroma. The pseudorosette structures are formed by the circumferential arrangement of small, dark cells around an eosinophilic core at the cente...
Interobserver Reproducibility of Pelvicalyceal Invasion in Renal Cell Carcinoma Nephrectomies Among Genitourinary Pathologists [0.03%]
泌尿系统病理学家之间对肾细胞癌肾切除标本盆腔肾盏侵袭的观察者间再现性研究
Ankur R Sangoi,Mahmut Akgul,Aysha Mubeen et al.
Ankur R Sangoi et al.
Pelvicalyceal invasion (PCI) is a relatively novel pT3a staging parameter for renal cell carcinoma (RCC) nephrectomies. While interobserver reproducibility staging studies of sinus/vascular invasion in RCC exist, a similar evaluation for PC...
Tubulocystic Renal Cell Carcinoma With Pure Morphology and Confirmed "Wild Type" FH/2SC Immunophenotype: Clinicopathologic Series of 30 Patients [0.03%]
具有纯合形态和确认的“野生型”FH / 2SC免疫表型的管囊性肾细胞癌：30例患者的临床病理系列分析
Lara R Harik,Cristina Magi-Galluzzi,Varsha Manusha et al.
Lara R Harik et al.
Tubulocystic renal cell carcinoma is a rare neoplasm, first adopted into the WHO classification of kidney tumors in 2016. The diagnostic criteria were refined in the 2022 WHO classification, requiring "pure morphology" and exclusion of othe...
Psammomatous Calcifications Identified in Targeted Needle Biopsies and Radical Prostatectomy From IDH1 Mutant Prostatic Adenocarcinoma: Case Report and Literature Review [0.03%]
IDH1突变型前列腺腺癌靶向针吸活检和根治性前列腺切除术中出现砂粒样钙化：病例报告及文献复习
Yang Zong,Mark Sharobim,Edward M Lawrence et al.
Yang Zong et al.
IDH1 mutant prostatic adenocarcinoma represents a small fraction of prostate cancer with distinct epigenetic changes, characterized by genome-wide DNA hypermethylation. Recently, prostatic adenocarcinoma with intratumoral psammomatous calci...
Clinicopathologic and Molecular Study of TFEB-altered Renal Cell Carcinomas: Tumors With Frequent PDL1 Expression [0.03%]
TFEB改变的肾细胞癌的临床病理和分子研究：PD-L1阳性表达频率高的肿瘤
Mengxin Zhang,Jie Xian,Jiaxiang Tang et al.
Mengxin Zhang et al.
TFEB-altered renal cell carcinoma (RCC) included TFEB-rearranged and TFEB-amplified RCC with unclear clinicopathological features and treatment options. Cases of TFEB-altered RCCs were collected. Fourteen cases showed TFEB rearrangement. Fi...
Defining a Histologic Scoring System for Gestational Alloimmune Liver Disease [0.03%]
定义妊娠同种免疫性肝病的组织学评分系统
Katie Conover,Samantha Saul,Catherine A Chapin et al.
Katie Conover et al.
Gestational alloimmune liver disease (GALD) is a leading cause of neonatal acute liver failure (ALF) with unique histologic features but no established histologic scoring criteria. This study aimed to develop an accurate histologic scoring ...
The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas [0.03%]
TRBC1免疫组化在T细胞淋巴瘤诊断中的应用价值
Pranav P Patwardhan,Ahmad Al-Attar,Nidhi Aggarwal et al.
Pranav P Patwardhan et al.
T-cell receptor β chain constant region 1 (TRBC1) is a useful marker for the detection of clonal T-cell populations and has been used in flow cytometry, with limited data on its utility as an immunohistochemical marker. We evaluated TRBC1 ...
Massive/Mass-forming Ductular Reaction Associated With Vascular Occlusion in Various Underlying Basic Liver Diseases [0.03%]
各种基础肝病相关的血管闭塞伴导管样反应重度增生
Anne Kristin Fischer,Reinhard Büttner,Hans-Peter Fischer
Anne Kristin Fischer
Massive/mass-forming ductular reaction of the liver (MDR) is occasionally in the differential diagnosis with true bile duct tumors. Our diagnostic histomorphological and immunohistochemical study of 14 cases from a consultant collective of ...
Clinicopathologic and Genomic Features of Gastric-Type Intraductal Papillary Neoplasm of the Bile Duct: Potential Role of STK11 in Malignant Progression [0.03%]
胃型胆管乳头状黏液性内瘤的临床病理及基因组特征：STK11在恶性转化中的潜在作用
Yuki Shimada,Takeo Yamamoto,Koji Shindo et al.
Yuki Shimada et al.
Gastric-type intraductal papillary neoplasm of the bile duct (G-type IPNB) remains an underexplored subtype of IPNBs, with limited molecular characterization. This study aimed to elucidate the clinicopathologic and genomic features of G-typ...