Clinicopathologic Study of 39 Mismatch Repair-deficient Sarcomas Demonstrates Recurrent Histologic Patterns and Supports Universal Screening of Pleomorphic Rhabdomyosarcoma, Uterine Leiomyosarcoma, and Undifferentiated and Unclassified Sarcomas [0.03%]
DNA错配修复缺陷型肉瘤的临床病理研究显示了反复出现的组织学模式，并支持对多形性横纹肌肉瘤、子宫平滑肌肉瘤以及未分化和不明类型肉瘤进行普遍筛查
Igor Odintsov,Jonathan A Nowak,Esther Baranov et al.
Igor Odintsov et al.
Mismatch repair-deficient (dMMR) sarcomas are rare and incompletely characterized. Here, we studied 39 sarcomas with high microsatellite instability (MSI-H) and/or biallelic MMR gene inactivation (21 MSH2, 9 MLH1, 4 PMS2, 4 MSH6, 1 EPCAM). ...
DLL3 Expression in a Genotyped Cohort of Sporadic Medullary Thyroid Carcinomas [0.03%]
一组遗传学测定的散发性甲状腺髓样癌中的DLL3表达
Maria Christina Riascos,Fedaa Najdawi,Sara Ahmadi et al.
Maria Christina Riascos et al.
Delta-like ligand 3 (DLL3) has been identified as a therapeutic target in high-grade neuroendocrine carcinomas, particularly small cell lung carcinoma. Data on DLL3 expression in medullary thyroid carcinoma (MTC) are limited; moreover, the ...
Giant Cell Urothelial Carcinoma: Morphometric Insights and Associations With Aggressive Clinical Features [0.03%]
巨大细胞型尿路上皮癌的形态计量学特征及与侵袭性临床特点的关系
Huili Li,Amir Akbari,Matthew Schuler et al.
Huili Li et al.
Giant cell urothelial carcinoma (GCUC) is an exceedingly rare histologic subtype with 50+ reported cases. To date, 3 case series have been reported. Scant chemotherapy and immunotherapy responses were reported with variable results. We repo...
Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors [0.03%]
CRTC1::TRIM11融合的皮肤肿瘤的临床转归和预后判断
Nithya S Trichy,Jonathan Braat,Lindsay J Holic et al.
Nithya S Trichy et al.
Since the original description of CRTC1::TRIM11 fusion cutaneous tumors (CTCT) in 2018, an increasing number of cases with metastatic behavior have been reported, yet there are limited studies analyzing prognostic parameters. This expanding...
Hypertrophic Lichen Sclerosus: A Form of "Atypical" Lichen Sclerosus in the Pathway to HPV-Independent Squamous Cell Carcinoma of the Vulva [0.03%]
肥厚性硬化性苔藓：外阴人乳头瘤病毒阴性的鳞状细胞癌途径中的“非典型”硬化性苔藓形式
Susanne K Jeffus,Carli Cox,Sara C Shalin et al.
Susanne K Jeffus et al.
Hypertrophic lichen sclerosus (HLS) is poorly characterized. A recent study described an atypical form of LS (p53 wild type) with a CK17/D2-40 immunohistochemical profile intermediate between classic LS and differentiated vulvar intraepithe...
TRBC1 Immunohistochemistry Utilization in Formalin-fixed Paraffin-embedded Tissue as an Adjunct to T-cell Clonality Testing in the Assessment of Cutaneous Lymphoproliferative Disorders [0.03%]
TRBC1免疫组化在甲醛固定石蜡包埋组织中的应用作为T细胞克隆性的辅助检测在皮肤淋巴增生性疾病的评估中应用研究
David G Grand,Jeffrey M Cloutier,Sarah R Palmer-DeClara et al.
David G Grand et al.
T-cell receptor β chain constant region 1 (TRBC1) immunohistochemistry (IHC) has emerged as a novel tool for identifying T-cell clonality in skin biopsies. Its performance in routine formalin-fixed, paraffin-embedded (FFPE) skin specimens ...
Ovarian Mucinous Neoplasms Associated With Mesonephric-like Lesions: An Updated Study With Novel Pathologic Features [0.03%]
伴有中肾旁管样病变的卵巢粘液性肿瘤：具有新颖病理特征的更新研究
Colton Smith,Jonathan Dudley,Johanna Savage et al.
Colton Smith et al.
The coexistence of benign mesonephric-like proliferation (MLP), mesonephric-like hyperplasia (MLH), and mesonephric-like adenocarcinoma (MLA) with ovarian mucinous cystadenoma or mucinous borderline tumor (MBT) has been previously reported;...
Highly Vascularized Scars in Cases of Regressed Testicular Germ Cell Tumors: An Occasional Mimic of Hemangioma and a Diagnostic Pitfall [0.03%]
退化性睾丸生殖细胞肿瘤病例中的高血管化瘢痕：一种偶尔模仿血管瘤的病变及诊断陷阱
Thomas M Ulbright,Ani Toklu,Andres M Acosta
Thomas M Ulbright
We identified 34 cases of regressed testicular germ cell tumors with highly vascularized scars; in 4 cases, the blood vessels were so prominent that hemangioma rather than germ cell tumor regression was considered, a misinterpretation that ...
Urothelial Carcinoma in Children and Young Adults is Characterized by Higher Frequency of HRAS Mutations and Lower Prevalence of TERT Promoter and FGFR3 Mutations [0.03%]
儿童和年轻人的尿路上皮癌具有HRAS突变频率高和TERT启动子及FGFR3突变低的特点
Liang Cheng,Hui Min Tan,Antonio Lopez-Beltran et al.
Liang Cheng et al.
Urothelial carcinoma in young patients is exceedingly rare, and their molecular oncogenesis is not well understood. In this study, we investigated the frequencies of HRAS, TERT promoter, and FGFR3 mutations in a cohort of 31 urothelial neop...
Challenges in Diagnosing High-grade B-cell Lymphoma, NOS: Poor Interobserver Agreement on Its Morphologic Definition-An LLMPP Study [0.03%]
高侵袭性B细胞淋巴瘤（NOS）诊断困难：形态学定义的观察者间一致性差——来自中国淋巴瘤联盟的研究
Katrin S Kurz,Sarah L Ondrejka,Brett Collinge et al.
Katrin S Kurz et al.
High-grade B-cell lymphoma, not otherwise specified (HGBCL, NOS), is defined by morphologic features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL). Lymphomas with a complex 11q aberration or concurrent MYC-...