Atypical Placental Site Nodule and Related Lesions: Interobserver Reproducibility [0.03%]
非典型胎盘部位囊肿及其相关病变的再观重复性研究
Lawrence Hsu Lin,Natalia Buza,Mojgan Devouassoux-Shisheboran et al.
Lawrence Hsu Lin et al.
Placental site nodule (PSN) and atypical placental site nodule (APSN) are chorionic-type intermediate trophoblastic lesions, the latter characterized by worrisome histologic characteristics and risk for subsequent trophoblastic neoplasia, m...
Intraductal Carcinoma of the Prostate With a Solid Nest Pattern May Be More Aggressive Than Gleason Grade 5 Conventional Prostatic Adenocarcinoma [0.03%]
具有实巢模式的前列腺导管内癌可能比 Gleason 5 级别常规前列腺腺癌更具侵袭性
Hangchuan Shi,Ying Wang,Hiroshi Miyamoto
Hangchuan Shi
The grading of intraductal carcinoma of the prostate (IDC-P) associated with conventional prostatic adenocarcinoma (CPA) remains controversial, particularly regarding whether IDC-P exhibiting a solid nest pattern is prognostically equivalen...
Fenestrating Adenocarcinoma: A Novel Salivary Gland Cancer With EWSR1::BEND2 Fusion and Predilection for the Pharynx [0.03%]
具有EWSR1::BEND2融合和偏爱咽部特征的fenestrating腺癌：一种新型的涎腺癌
Dhuha Al-Sajee,Lisa M Rooper,Justin A Bishop et al.
Dhuha Al-Sajee et al.
Most salivary gland tumors are found to have genetic fusions driving their oncogenesis, with an explosion of such findings in recent years. They typically represent previously identified and well-characterized tumors and the fusions are gen...
FGFR1 Mutations Are Rare Alternate Oncogenic Drivers in FOXL2-Wildtype Adult Granulosa Cell Tumors of the Ovary [0.03%]
成人卵巢FOXL2野生型颗粒细胞瘤中FGFR1突变罕见地充当替代致癌驱动因素
David L Kolin,Douglas A Mata,Douglas I Lin et al.
David L Kolin et al.
Adult granulosa cell tumors (aGCTs) of the ovary are uniquely characterized by an almost ubiquitous somatic mutation in the FOXL2 gene (p.C134W). We report the first series of 7 aGCTs harboring pathogenic FGFR1 kinase domain mutations, prov...
Clinicopathogenomic Characteristics of Primary and Metastatic Melanomas With RAF1 and BRAF Fusions [0.03%]
具有RAF1和BRAF融合的原发性和转移性黑色素瘤的临床病理基因组特征
Cecilia Lezcano,Israel S Kasago,Haiming Tang et al.
Cecilia Lezcano et al.
Point mutations in genes of the mitogen-activated protein kinase (MAPK) pathway are the most frequent oncogenic drivers of melanocytic neoplasms, whereas gene fusions are comparatively rare. Kinase fusions are among the molecular alteration...
Molecular Heterogeneity and Clinicopathologic Correlations in Inflammatory Myofibroblastic Tumors of the Urinary Bladder: A Study of 20 Cases With Predominant FN1::ALK Fusions and Novel Kinase Rearrangements [0.03%]
以FN1::ALK融合及新型激酶重排为主的泌尿膀胱炎性肌成纤维细胞肿瘤的分子异质性和临床病理相关性研究（20例报告）
Ming Zhao,Xiaoqun Yang,Zhe Zhang et al.
Ming Zhao et al.
Inflammatory myofibroblastic tumors (IMTs) of the urinary bladder are rare mesenchymal neoplasms with an incompletely defined molecular spectrum. This integrated clinicopathologic and molecular study of 20 bladder IMTs utilized immunohistoc...
Dual TRBC1-CD3 Immunohistochemistry Shows High Diagnostic Utility in Differentiating Mycosis Fungoides/Sezary Syndrome From Reactive Inflammatory Dermatoses in Skin Biopsies [0.03%]
双重TRBC1-CD3免疫组化在皮肤活检中鉴别MF/SS与反应性炎症皮肤病中的高诊断价值
Natasha E Lewis,David J DiCaudo,Jiehao Zhou et al.
Natasha E Lewis et al.
Evaluation of T-cell receptor (TCR) β-chain constant region 1 (TRBC1) expression is an alternative T-cell clonality assessment method. However, evaluation of TRBC1 immunohistochemistry (IHC) for distinguishing mycosis fungoides (MF)/Sezary...
Dual TRBC1-CD3 Immunohistochemistry Shows High Diagnostic Utility in Differentiating Mycosis Fungoides/Sezary Syndrome From Reactive Inflammatory Dermatoses in Skin Biopsies [0.03%]
双重TRBC1-CD3免疫组化在皮肤活检中鉴别蕈样霉菌病/塞扎里综合征与反应性炎症皮肤病中的高诊断价值
Natasha E Lewis,David J DiCaudo,Jiehao Zhou et al.
Natasha E Lewis et al.
Evaluation of T-cell receptor (TCR) β-chain constant region 1 (TRBC1) expression is an alternative T-cell clonality assessment method. However, evaluation of TRBC1 immunohistochemistry (IHC) for distinguishing mycosis fungoides (MF)/Sezary...
Anaplastic Juvenile Granulosa Cell Tumor: A Report of 10 Cases of an Unemphasized Variant With Adverse Prognostic Features Characterized by TP53 Inactivation With MYC Family Amplifications [0.03%]
非典型性 juvenile颗粒细胞瘤：一组伴不良预后特征且带有TP53失活及MYC家族扩增的少见类型病例报告
Baris Boyraz,Robert H Young,Esther Oliva et al.
Baris Boyraz et al.
Ten anaplastic juvenile granulosa cell tumors (JGCT) with architectural and cytologic features that differ from those seen in conventional JGCTs were identified from patients who ranged from 7 to 44 (median 13) years. The tumors measured fr...
PRRX1-rearranged Fibroblastic Tumors: A Clinicopathologic and Molecular Study of 18 Cases Including a Novel PRRX1::EP300 Fusion [0.03%]
PRRX1重排的纤维瘤病：18例包括新型PRRX1::EP300融合的临床病理和分子研究
Carina A Dehner,Jorge Torres-Mora,Judith Jebastin Thangaiah et al.
Carina A Dehner et al.
With the first series of PRRX1-rearranged tumors published in 2019, the spectrum of these so-called fibroblastic tumors has been expanded. Since then, several smaller case series have been published; however, our understanding of them conti...