Proteomic Analysis Identifies Potential Biomarkers of ELOC-Mutated Renal Cell Carcinoma [0.03%]
蛋白质组学分析鉴定出ELOC突变型肾细胞癌的潜在生物标志物
Akihiko Fukagawa,Yasuhito Arai,Akiko Maeshima et al.
Akihiko Fukagawa et al.
ELOC-mutated renal cell carcinoma (RCC) is a rare tumor with only ∼40 cases reported to date; it shares a molecular background with clear cell RCC (ccRCC) in terms of hypoxia-inducible factor-alpha (HIF-α) protein accumulation. ELOC-mutat...
Limited Availability of Short Tandem Repeat Genotype Testing in the United States for Diagnosis of Partial Hydatidiform Mole: A Dilemma for Practicing Precision Medicine [0.03%]
美国限制使用短串联重复序列基因分型检测诊断部分水泡状胎块的现状：精准医疗面临的难题
Laura Warren,Laura J Tafe,W Patrick Devine et al.
Laura Warren et al.
The pathogenetic definition of a partial hydatidiform mole (PHM) is a diandric triploid gestation, thereby requiring short tandem repeat (STR) genotype testing for definitive diagnosis in formalin-fixed products of conception (POC) specimen...
Clinicopathologic Analysis of 43 Surgically Resected Lactotroph Pituitary Neuroendocrine Tumors Stratified by Surgical Indication: A Pathologic Reappraisal of Apparent Male Aggressiveness [0.03%]
基于手术适应证分层的43例手术切除泌乳素分泌垂体神经内分泌肿瘤的临床病理分析：对男性易感性的病理再评价
Noriaki Tanabe,Naoko Inoshita,Eri Kasuga et al.
Noriaki Tanabe et al.
Male lactotroph pituitary neuroendocrine tumors (PitNETs) are often considered more aggressive than those in women, but surgically treated cohorts are highly selected and may reflect differences in presentation and indication for surgery. W...
Histiocyte-Rich Renal Epithelial Neoplasm: A Morphology Associated With Folliculin Mutations and Birt-Hogg-Dubé Syndrome [0.03%]
与Birt-Hogg-Dube综合征相关的富巨噬细胞肾上皮肿瘤及其与 folliculin基因突变的关系
Pedram Argani,Ezra Baraban,Angela Sanguino et al.
Pedram Argani et al.
So-called hybrid oncocytic tumor (HOT) is the renal neoplasm most commonly associated with the germline folliculin (FLCN) mutations that define Birt-Hogg-Dubé syndrome. However, the spectrum of renal epithelial neoplasms associated with FL...
Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status: A Large Case Series From Single Institution [0.03%]
大肠传统锯齿状腺瘤及其可能的癌前病变的临床病理和分子分析（侧重于RSPO融合状态）：来自单一机构的大样本系列研究
Yuichiro Kadomatsu,Tsuyoshi Saito,Eiji Kamba et al.
Yuichiro Kadomatsu et al.
Colorectal serrated lesions are divided into hyperplastic polyps (HP), sessile serrated lesions (SSL), and traditional serrated adenomas (TSA) in the sixth edition of the WHO classification. In 2018, superficially serrated adenoma (SuSA) wa...
NF2/Merlin Immunohistochemistry Helps Distinguish Collecting Duct Carcinoma From Upper Tract Urothelial Carcinoma [0.03%]
NF2/ Merlin免疫组化有助于鉴别集合管癌和上尿路尿路上皮癌
Ezra Baraban,Doreen N Palsgrove,Cansu Yol et al.
Ezra Baraban et al.
Collecting duct carcinoma (CDC) and upper tract urothelial carcinoma (UTUC) can exhibit overlapping morphologic features, particularly in limited biopsies, creating diagnostic challenges with significant therapeutic implications. Recent mol...
Neuroendocrine Carcinoma of the Gallbladder: Clinicopathologic and Immunohistochemical Analysis of 31 Cases [0.03%]
31例胆囊神经内分泌癌的临床病理和免疫组化分析
Michelle D Reid,Burcin Pehlivanoglu,Bahar Memis et al.
Michelle D Reid et al.
Neuroendocrine carcinomas of the gallbladder (GBNECs) have been very poorly characterized. In this study, 31 NECs were identified through an analysis of 636 GB cancers and contrasted with the ordinary GBCs (O-GBCs) in the same cohort. Seven...
Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation Profile [0.03%]
具有极性反转的乳头状肾肿瘤是一种独特的远端肾单位起源肿瘤，具有特有的甲基化谱型
Kyung Park,Yuxiu Wang,Kisong Kim et al.
Kyung Park et al.
Papillary renal neoplasm with reverse polarity (PRNRP) has been proposed as a distinct subtype of renal cell neoplasm with recurrent KRAS mutations and indolent behavior. However, its epigenetic landscape is poorly understood. In this study...
Biallelic ARID1A Alterations: A Promising Novel Biomarker for Risk Stratification and Management in Pediatric Malignant Hepatocellular Tumors [0.03%]
ARID1A双等位基因改变：儿童恶性肝细胞肿瘤风险分层和管理的新生物标志物的前景
Kalyani R Patel,Martin Urbicain,Stephen F Sarabia et al.
Kalyani R Patel et al.
Somatic mutations and copy number alterations of the adenine-thymine (AT)-rich interactive domain-containing protein 1A (ARID1A), a tumor suppressor gene, are associated with poor prognosis in many cancers, including adult hepatocellular ca...
Absent Cyclin D1 Expression in Myeloid Sarcomas Distinguishes From Malignant Histiocytic Neoplasms: When Morphologic Ambiguity is Deceptive [0.03%]
cyclin D1在髓系肉瘤中的不表达可助其与恶性组织细胞肿瘤区别：当形态学模棱两可是具有误导性的
Alyssa M Lee,Neha Seth,Wayne Tam et al.
Alyssa M Lee et al.
Myeloid sarcoma (MS) is a tumor mass involving any extramedullary site composed of myeloid-lineage blasts with myeloid, myelomonocytic, or monocytic differentiation. Distinguishing MS from malignant histiocytic neoplasms (MHNs) is diagnosti...